Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 Biomarker group BEFREE Multiple mechanisms in different disease stages are responsible for immunopathology in MS. HLA Class II DR2b (DRB1*1501 β, DRA1*0101 α) is the strongest genetic risk factor for MS. Remnants of ancient retroviruses in the human genome, termed human endogenous retroviruses (HERV), and Epstein-Barr virus (EBV) infection are also associated with MS. 31689443 2020
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 Biomarker group BEFREE The effect of remote EBV infection on the risk of pediatric MS depended on race and <i>HLA-DRB1*15:01</i> status. 30349857 2018
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 Biomarker group BEFREE One of the main risk factors, also confirmed in pediatric MS, is HLA DRB1*1501 In addition to genetic factors, a large part of disease susceptibility in adults is conferred by environmental risk factors such as low vitamin D status, exposure to cigarette smoking, and remote Epstein-Barr virus (EBV) infection. 27572857 2016
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 Biomarker group BEFREE An interaction effect between EBV infection and HLA-DRB1*1501 on MS was observed on the additive scale (S, 1.43; 95%CI, 1.05-1.95, P = 0.023), but no interaction effect was observed on the multiplicative scale (OR, 0.86, 95%CI, 0.59-1.26). 26656273 2015
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 Biomarker group BEFREE To determine the association of EBV infection with MS incidence, and to investigate HLA-DRB1*1501 as a potential genetic risk factor for MS in Kuwait. 26198919 2015
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 GeneticVariation group GWASDB A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1). 23326239 2013
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 GeneticVariation group GWASCAT A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1). 23326239 2013
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 Biomarker group BEFREE Our study suggests that MS patients harboring DRB1*0405, a genetic risk factor for MS in the Japanese population, have a younger age at onset and a relatively benign disease course, while DRB1*0405-negative MS patients have features similar to Western-type MS in terms of association with Epstein-Barr virus infection and DRB1*1501. 23152786 2012
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 Biomarker group BEFREE HLA-DRB1*0404, an RA predisposing allele, is associated with low frequencies of T cells specific for EBV gp110, a replicative phase glycoprotein critical for the control of EBV infection. 15288002 2004
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 Biomarker group BEFREE Since HLA-DR was recently described as a co-receptor for EBV infection of B cells, we also determined HLA-DRB1 alleles in the EBV- group. 10361236 1999