HLA-DRB1
|
0.180 |
Biomarker
|
group |
BEFREE |
Multiple mechanisms in different disease stages are responsible for immunopathology in MS. HLA Class II DR2b (DRB1*1501 β, DRA1*0101 α) is the strongest genetic risk factor for MS. Remnants of ancient retroviruses in the human genome, termed human endogenous retroviruses (HERV), and Epstein-Barr virus (EBV) infection are also associated with MS.
|
31689443 |
2020 |
HLA-DRB1
|
0.180 |
Biomarker
|
group |
BEFREE |
The effect of remote EBV infection on the risk of pediatric MS depended on race and <i>HLA-DRB1*15:01</i> status.
|
30349857 |
2018 |
HLA-DRB1
|
0.180 |
Biomarker
|
group |
BEFREE |
One of the main risk factors, also confirmed in pediatric MS, is HLA DRB1*1501 In addition to genetic factors, a large part of disease susceptibility in adults is conferred by environmental risk factors such as low vitamin D status, exposure to cigarette smoking, and remote Epstein-Barr virus (EBV) infection.
|
27572857 |
2016 |
HLA-DRB1
|
0.180 |
Biomarker
|
group |
BEFREE |
An interaction effect between EBV infection and HLA-DRB1*1501 on MS was observed on the additive scale (S, 1.43; 95%CI, 1.05-1.95, P = 0.023), but no interaction effect was observed on the multiplicative scale (OR, 0.86, 95%CI, 0.59-1.26).
|
26656273 |
2015 |
HLA-DRB1
|
0.180 |
Biomarker
|
group |
BEFREE |
To determine the association of EBV infection with MS incidence, and to investigate HLA-DRB1*1501 as a potential genetic risk factor for MS in Kuwait.
|
26198919 |
2015 |
HLA-DRB1
|
0.180 |
GeneticVariation
|
group |
GWASDB |
A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1).
|
23326239 |
2013 |
HLA-DRB1
|
0.180 |
GeneticVariation
|
group |
GWASCAT |
A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1).
|
23326239 |
2013 |
HLA-DRB1
|
0.180 |
Biomarker
|
group |
BEFREE |
Our study suggests that MS patients harboring DRB1*0405, a genetic risk factor for MS in the Japanese population, have a younger age at onset and a relatively benign disease course, while DRB1*0405-negative MS patients have features similar to Western-type MS in terms of association with Epstein-Barr virus infection and DRB1*1501.
|
23152786 |
2012 |
HLA-DRB1
|
0.180 |
Biomarker
|
group |
BEFREE |
HLA-DRB1*0404, an RA predisposing allele, is associated with low frequencies of T cells specific for EBV gp110, a replicative phase glycoprotein critical for the control of EBV infection.
|
15288002 |
2004 |
HLA-DRB1
|
0.180 |
Biomarker
|
group |
BEFREE |
Since HLA-DR was recently described as a co-receptor for EBV infection of B cells, we also determined HLA-DRB1 alleles in the EBV- group.
|
10361236 |
1999 |