Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 Biomarker group BEFREE Multiple mechanisms in different disease stages are responsible for immunopathology in MS. HLA Class II DR2b (DRB1*1501 β, DRA1*0101 α) is the strongest genetic risk factor for MS. Remnants of ancient retroviruses in the human genome, termed human endogenous retroviruses (HERV), and Epstein-Barr virus (EBV) infection are also associated with MS. 31689443 2020
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 Biomarker group BEFREE The effect of remote EBV infection on the risk of pediatric MS depended on race and <i>HLA-DRB1*15:01</i> status. 30349857 2018
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 Biomarker group BEFREE One of the main risk factors, also confirmed in pediatric MS, is HLA DRB1*1501 In addition to genetic factors, a large part of disease susceptibility in adults is conferred by environmental risk factors such as low vitamin D status, exposure to cigarette smoking, and remote Epstein-Barr virus (EBV) infection. 27572857 2016
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 Biomarker group BEFREE An interaction effect between EBV infection and HLA-DRB1*1501 on MS was observed on the additive scale (S, 1.43; 95%CI, 1.05-1.95, P = 0.023), but no interaction effect was observed on the multiplicative scale (OR, 0.86, 95%CI, 0.59-1.26). 26656273 2015
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 Biomarker group BEFREE To determine the association of EBV infection with MS incidence, and to investigate HLA-DRB1*1501 as a potential genetic risk factor for MS in Kuwait. 26198919 2015
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 GeneticVariation group GWASDB A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1). 23326239 2013
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 GeneticVariation group GWASCAT A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1). 23326239 2013
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 Biomarker group BEFREE Our study suggests that MS patients harboring DRB1*0405, a genetic risk factor for MS in the Japanese population, have a younger age at onset and a relatively benign disease course, while DRB1*0405-negative MS patients have features similar to Western-type MS in terms of association with Epstein-Barr virus infection and DRB1*1501. 23152786 2012
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 Biomarker group BEFREE HLA-DRB1*0404, an RA predisposing allele, is associated with low frequencies of T cells specific for EBV gp110, a replicative phase glycoprotein critical for the control of EBV infection. 15288002 2004
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
0.180 Biomarker group BEFREE Since HLA-DR was recently described as a co-receptor for EBV infection of B cells, we also determined HLA-DRB1 alleles in the EBV- group. 10361236 1999
Entrez Id: 3117
Gene Symbol: HLA-DQA1
HLA-DQA1
0.110 GeneticVariation group GWASDB A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1). 23326239 2013
Entrez Id: 3117
Gene Symbol: HLA-DQA1
HLA-DQA1
0.110 GeneticVariation group BEFREE The aims of this study were to detect the presence of Epstein-Barr virus DNA (EBV-DNA) in peripheral blood of NPC patients, to molecularly define human leukocyte antigens (HLA) DRB1*, DQA1* and DQB1* allele frequencies, and, finally, to determine whether the genetic predisposition of an individual to NPC depends on the liability to EBV infection. 18535809 2008
Entrez Id: 4068
Gene Symbol: SH2D1A
SH2D1A
0.100 GeneticVariation group BEFREE Epstein-Barr virus (EBV) infection was significantly more common in SAP-deficient 10/13 (76.9%) than XIAP-deficient 2/7 (28.6%) patients, as was hypogammaglobulinemia (10/13 (76.9%) vs. 1/7 (14.3%)). 31754776 2020
Entrez Id: 325
Gene Symbol: APCS
APCS
0.100 GeneticVariation group BEFREE Epstein-Barr virus (EBV) infection was significantly more common in SAP-deficient 10/13 (76.9%) than XIAP-deficient 2/7 (28.6%) patients, as was hypogammaglobulinemia (10/13 (76.9%) vs. 1/7 (14.3%)). 31754776 2020
Entrez Id: 4609
Gene Symbol: MYC
MYC
0.100 GeneticVariation group BEFREE The 2016 WHO classification defines diffuse large B-cell lymphoma subtypes based on EBV infection and oncogenic rearrangements of MYC/BCL2/BCL6 as drivers of lymphomagenesis. 31123031 2020
Entrez Id: 9260
Gene Symbol: PDLIM7
PDLIM7
0.100 GeneticVariation group BEFREE As oral cavity is the main location of Epstein-Barr virus (EBV) latency and shedding, and as EBV-encoded latent membrane protein-1 (LMP-1) has a crucial role in cell transformation, association between EBV infection, LMP-1 expression and oral malignancy is of interest. 31291930 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE Host cell transcriptional changes in response to EBV infection classified tumors into two molecular subtypes based on patterns of IFN signature genes and immune checkpoint markers, such as PD-L1 and IDO1. 31481499 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 Biomarker group BEFREE The numbers of EBER+PD-L1+ cells were directly correlated with the numbers of EBER+CD3+ and EBER+CD8+ cells suggesting a possible role for PD-L1 in EBV infection of T-cells. 30842768 2019
Entrez Id: 9260
Gene Symbol: PDLIM7
PDLIM7
0.100 Biomarker group BEFREE Fibronectin is regarded as a prognosticator in NPC and its involvement in cell motility has been reported in EBV infection and viral latent membrane protein 1 (LMP1) overexpression NPC cell lines. 30551431 2019
Entrez Id: 9260
Gene Symbol: PDLIM7
PDLIM7
0.100 Biomarker group BEFREE Together, these findings suggest that LMP1 modulates different post-translational modifications of SENP2 in order to modulate its biology and identify a third member of the sumoylation machinery that is manipulated by LMP1 during latent EBV infections, which can affect oncogenesis. 31266997 2019
Entrez Id: 4068
Gene Symbol: SH2D1A
SH2D1A
0.100 GeneticVariation group BEFREE Pathogenic hemizygous variants in the SH2D1A gene cause X-linked lymphoproliferative (XLP) syndrome, a rare primary immunodeficiency usually associated with fatal Epstein-Barr virus infection. 30990878 2019
Entrez Id: 29126
Gene Symbol: CD274
CD274
0.100 AlteredExpression group BEFREE We analyzed the outcome of 30 relapsed or refractory NHL patients treated with pembrolizumab, and compared the outcome between Epstein-Barr virus (EBV)‒positive and negative subtypes because EBV infection of tumor cells can upregulate PDL1 expression. 30025443 2019
Entrez Id: 9260
Gene Symbol: PDLIM7
PDLIM7
0.100 AlteredExpression group BEFREE The knockout of either LMP1 or LMP2A blocked the eIF4E activation, which is induced either by the EBV infection or by the overexpression of LMP1 or LMP2A. 31673282 2019
Entrez Id: 1380
Gene Symbol: CR2
CR2
0.100 Biomarker group BEFREE If peripheral T cell lymphoma or T cell lymphomas of follicular helper origin are considered in the differential diagnosis, the following panel is recommended: pan T cell antigens, CD4, CD8, one or more follicular dendritic cell markers, and assessment for Epstein-Barr virus (EBV) infection, preferably EBV encoded RNA (EBER) as assessed by in situ hybridization When the differential diagnosis includes nodular lymphocyte predominant Hodgkin lymphoma, recommended additional studies include OCT2, CD21 and/or CD23, PD1, and assessment for EBV infection. 30802809 2019
Entrez Id: 1380
Gene Symbol: CR2
CR2
0.100 Biomarker group BEFREE It has been shown that both CD21 and CD83 contribute to the resolution of inflammation occurred in MS. CD21 and CD83 have also been ascribed to Epstein Barr virus (EBV) infection (the prime suspect of MS causality) and the levels of vitamin D, respectively. 29759135 2018