Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.600 | Biomarker | disease | CTD_human | A nonpeptide, piperidine renin inhibitor provides renal and cardiac protection in double-transgenic mice expressing human renin and angiotensinogen genes. | 18679781 | 2008 | ||||
|
0.600 | Biomarker | disease | BEFREE | The renin angiotensin system modulates vascular structure and left ventricular hypertrophy via a number of trophic effects. | 11177655 | 2001 | ||||
|
0.600 | Biomarker | disease | BEFREE | We investigated the effect of renin-angiotensin system (RAS) blockade therapy on LV hypertrophy and mortality in patients undergoing TAVI. | 28986405 | 2018 | ||||
|
0.600 | Biomarker | disease | RGD | Comparison of the effects of cilnidipine and amlodipine on cardiac remodeling and diastolic dysfunction in Dahl salt-sensitive rats. | 22796710 | 2012 | ||||
|
0.600 | AlteredExpression | disease | BEFREE | Subsequent treatment with cilazapril significantly improved LV morphology and function in those with residual LV hypertrophy or elevated plasma renin activity. | 10937840 | 2000 | ||||
|
0.600 | AlteredExpression | disease | BEFREE | Both the activation of the renin angiotensin aldosterone system (RAAS) and elevations of circulating Fibroblast Growth Factor-23 (FGF-23) have been implicated in the pathogenesis of left ventricular hypertrophy (LVH) in chronic kidney disease. | 30120363 | 2018 | ||||
|
0.600 | AlteredExpression | disease | BEFREE | In hypertension the 825T allele is associated with low renin activity and appears to strongly predict the development of left ventricular hypertrophy. | 10978382 | 2000 | ||||
|
0.600 | AlteredExpression | disease | BEFREE | Enalapril-induced regression of left ventricular hypertrophy and improvement in left ventricular impaired diastolic filling were significantly greater in the DD genotype group than they were in the ID and II genotype groups, suggesting that the circulating and tissue renin-angiotensin systems, particularly the former system, are most active in hypertensive patients with the DD genotype. | 8986921 | 1996 | ||||
|
0.600 | AlteredExpression | disease | BEFREE | TGR rats showed left ventricular hypertrophy (54%), higher blood pressures (76 mmHg), and elevated plasma renin activity (seven-fold) compared to controls (P < 0.01). | 11518854 | 2001 |