| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.270 | AlteredExpression | disease | BEFREE | Renal cortical endothelial nitric oxide synthase mRNA was upregulated 7 fold while that of cystathione γ lyase was unaltered in the NO treated LVH rats (LVH-NO) group compared to LVH group. | 29447158 | 2018 | ||||
|
0.270 | GeneticVariation | disease | BEFREE | Considering the totality of available evidence, single-gene analyses of the NOS3 gene have not uncovered detectable genetic effects, and pathway-based analyses that examine interactions of multiple loci may be more informative about the complex genetic etiology of LVH. | 20482221 | 2010 | ||||
|
0.270 | GeneticVariation | disease | BEFREE | The purpose of the present study was to determine whether three common variants in NOS3 (the eNOS gene) are associated with the risk of LVH [LV (left ventricular) hypertrophy] in patients with essential hypertension. | 19132956 | 2009 | ||||
|
0.270 | GeneticVariation | disease | BEFREE | Nitric oxide is involved in regulation of cardiomyocyte genes but it is not known If endothelial nitric oxide synthase 4 gene polymorphisms are related with left ventricular hypertrophy. | 16923191 | 2006 | ||||
|
0.270 | GeneticVariation | disease | LHGDN | These findings, not previously described, provide important preliminary evidence to suggest an increased susceptibility to LVH in African Americans who carry the 894T variant of the eNOS gene and have high-normal blood pressure. | 15712782 | 2005 | ||||
|
0.270 | GeneticVariation | disease | LHGDN | Therefore, we show associations between Glu allele of NOS3 (Glu298Asp) and left ventricular hypertrophy and between 4a allele (ecNOS4a/4b) and diastolic dysfunction in patients with essential hypertension. | 12494183 | 2002 | ||||
|
0.270 | Biomarker | disease | RGD | This dysregulation of NOS3 could contribute to contractile dysfunction in left ventricular hypertrophy. | 9747440 | 1998 | ||||
|
0.270 | GeneticVariation | disease | BEFREE | In conclusion, the 33-repeat allele of the endothelial cNOS gene is associated with EH without LVH, and may be a genetic marker of EH in Japanese subjects. | 9084930 | 1997 |