Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5972
Gene Symbol: REN
REN
0.400 GeneticVariation disease BEFREE Association of renin-angiotensin-aldosterone system gene polymorphisms with left ventricular hypertrophy in patients with heart failure with preserved ejection fraction: A case-control study. 28513230 2018
Entrez Id: 5972
Gene Symbol: REN
REN
0.400 GeneticVariation disease BEFREE Being a major contributor to the development of diastolic heart dysfunction, the renin angiotensin aldosterone system and its genetic variations are thought to induce LVH in hypertensive hearts apart from haemodynamic factors. 26861937 2016
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.400 GeneticVariation disease BEFREE Association of ACE gene D polymorphism with left ventricular hypertrophy in patients with diastolic heart failure: a case-control study. 26861937 2016
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.400 GeneticVariation disease BEFREE Angiotensin-converting enzyme insertion/deletion polymorphism, 24-h blood pressure profile and left ventricular hypertrophy in hypertensive individuals: a cross-sectional study. 26336879 2016
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.400 GeneticVariation disease BEFREE Telomere length is associated with ACE I/D polymorphism in hypertensive patients with left ventricular hypertrophy. 23077078 2014
Entrez Id: 183
Gene Symbol: AGT
AGT
0.400 Biomarker disease CTD_human In contrast to TAC, antagonizing the function of CTGF had no effect on LV dysfunction or LV hypertrophy in mice subjected to 4-week angiotensin II infusion. 24688123 2014
Entrez Id: 183
Gene Symbol: AGT
AGT
0.400 Therapeutic disease CTD_human In contrast to TAC, antagonizing the function of CTGF had no effect on LV dysfunction or LV hypertrophy in mice subjected to 4-week angiotensin II infusion. 24688123 2014
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.400 GeneticVariation disease BEFREE Angiotensin-converting enzyme gene deletion allele increases the risk of left ventricular hypertrophy: evidence from a meta-analysis. 22773337 2013
Entrez Id: 5972
Gene Symbol: REN
REN
0.400 GeneticVariation disease BEFREE Polymorphisms of the renin-angiotensin-aldosterone system (RAAS) represent an attractive hypothesis as potential disease modifiers, as these genetic variants alter the 'activation status' of the RAAS, which leads to more left ventricular hypertrophy through different pathways. 21507890 2012
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.400 Biomarker disease BEFREE Also, ACE and the 12 other genotypes did not affect risk of the primary composite endpoint or its components stroke, myocardial infarction, and cardiovascular death, or treatment differences between losartan and atenolol on these endpoints, as assessed by Cox proportional hazards models including baseline Framingham risk score and LVH. 20065889 2010
Entrez Id: 183
Gene Symbol: AGT
AGT
0.400 Therapeutic disease CTD_human Angiotensin-(1-7) ameliorates myocardial remodeling and interstitial fibrosis in spontaneous hypertension: role of MMPs/TIMPs. 20837116 2010
Entrez Id: 183
Gene Symbol: AGT
AGT
0.400 Biomarker disease CTD_human Angiotensin-(1-7) ameliorates myocardial remodeling and interstitial fibrosis in spontaneous hypertension: role of MMPs/TIMPs. 20837116 2010
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.400 GeneticVariation disease BEFREE ACE and AGTR1 polymorphisms and left ventricular hypertrophy in endurance athletes. 19997001 2010
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.400 GeneticVariation disease BEFREE An association between the insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene and the progression of left ventricular hypertrophy in patients with hypertrophic cardiomyopathy has been reported. 20179607 2010
Entrez Id: 183
Gene Symbol: AGT
AGT
0.400 Biomarker disease CTD_human A nonpeptide, piperidine renin inhibitor provides renal and cardiac protection in double-transgenic mice expressing human renin and angiotensinogen genes. 18679781 2009
Entrez Id: 5972
Gene Symbol: REN
REN
0.400 GeneticVariation disease BEFREE Myocardial fibrosis in patients with symptomatic obstructive hypertrophic cardiomyopathy: correlation with echocardiographic measurements, sarcomeric genotypes, and pro-left ventricular hypertrophy polymorphisms involving the renin-angiotensin-aldosterone system. 18835191 2009
Entrez Id: 183
Gene Symbol: AGT
AGT
0.400 Biomarker disease BEFREE In addition, the induction of human cardiac fibroblasts (HCF) and human umbilical vein endothelial cells (HUVEC) with the LVH mediator angiotensin II enabled us to investigate uremic LVH progression in vitro. 19094982 2009
Entrez Id: 183
Gene Symbol: AGT
AGT
0.400 Therapeutic disease CTD_human A nonpeptide, piperidine renin inhibitor provides renal and cardiac protection in double-transgenic mice expressing human renin and angiotensinogen genes. 18679781 2009
Entrez Id: 183
Gene Symbol: AGT
AGT
0.400 Biomarker disease BEFREE We further unraveled robust increases in HCN2/HCN4 transcripts and protein levels, using real-time RT-PCR and Western blot analyses, in a rat model of left ventricular hypertrophy and in angiotensin II-induced neonatal ventricular hypertrophy. 19471099 2009
Entrez Id: 5972
Gene Symbol: REN
REN
0.400 Biomarker disease CTD_human A nonpeptide, piperidine renin inhibitor provides renal and cardiac protection in double-transgenic mice expressing human renin and angiotensinogen genes. 18679781 2009
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.400 GeneticVariation disease LHGDN I/D polymorphism of ACE gene and AC AT1 gene influence the development of hypertension and Left Ventricular Hypertrophy in Hemodialysis patients. 19112833 2009
Entrez Id: 5972
Gene Symbol: REN
REN
0.400 GeneticVariation disease BEFREE The association of renin-angiotensin system (RAS) polymorphisms and left-ventricular hypertrophy (LVH) may depend on the presence of risk factors for LVH, such as renal dysfunction. 17903694 2007
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.400 GeneticVariation disease BEFREE Angiotensin-converting enzyme gene 2350 G/A polymorphism is associated with left ventricular hypertrophy but not essential hypertension. 17460369 2007
Entrez Id: 183
Gene Symbol: AGT
AGT
0.400 GeneticVariation disease BEFREE Angiotensinogen M235T and T174M polymorphisms have individually been associated with elevated levels of plasma angiotensinogen, hypertension, and left ventricular hypertrophy. 17145981 2007
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.400 GeneticVariation disease LHGDN Association between left ventricular hypertrophy and the 2350A allele in hypertensive patients. 17460369 2007