Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2 		0.630 GeneticVariation disease BEFREE FGFR1 CNG (10.7%), FGFR1 mutation (2.7%), FGFR2 mutation (2.7%), FGFR4 mutation (5.3%), and FGFR3 fusion (1.3%) were detected in LSCC specimens by NGS. 27581340 2016
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2 		0.630 GeneticVariation disease GWASCAT Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations. 27197191 2016
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2 		0.630 GeneticVariation disease BEFREE Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma. 23786770 2013
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2 		0.630 GeneticVariation disease UNIPROT
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2 		0.630 GeneticVariation disease BEFREE FGFR2 and other FGFR kinase family gene alterations have been found in both lung squamous cell carcinoma and lung adenocarcinoma, although mouse models of FGFR-driven lung cancers have not been reported. 25035393 2014
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2 		0.630 GeneticVariation disease CLINVAR Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma. 23786770 2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease CLINVAR Randomized phase II study of dacomitinib (PF-00299804), an irreversible pan-human epidermal growth factor receptor inhibitor, versus erlotinib in patients with advanced non-small-cell lung cancer. 22753918 2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE Therefore, in contrast to advanced LADC, EGFR mutation testing may not be necessarily performed upfront in advanced LSQC because not only the mutation rate is low, but also the predictive value is insufficient. 25053390 2014
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE Detection of the EGFR mutation in exhaled breath condensate from a heavy smoker with squamous cell carcinoma of the lung. 21684624 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE Ten of 215 pure SQCCs (4.7%; 95% CI, 2.3%-8.4%) harbored mutations, including seven with PIK3CA, and each with AKT1, DDR2, and EGFR. 24158231 2014
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE The epidermal growth factor receptor (EGFR) mutations occur mostly in adenocarcinomas and rarely in squamous cell carcinoma of lung. 17186532 2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE This study was focused on EGFR somatic mutations and amplifications in squamous cell lung cancer. 20635059 2010
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE Targeting PKCι-PAK1 signaling pathways in EGFR and KRAS mutant adenocarcinoma and lung squamous cell carcinoma. 31660987 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE Activation of the BMP-BMPR pathway conferred resistance to EGFR-TKIs in lung squamous cell carcinoma patients with EGFR mutations. 26216950 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE EGFR mutation is associatedwith short PFS and the brain is the most common site of distant metastasis in patients with stage III non- squamous cell lung cancer treated with CCRT. 29914238 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE EGFR rs2233947 correlated with lung cancer in males, smokers, and in the squamous cell carcinoma lung cancer subtype (P<0.01). 31518089 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE To analyze the distribution of epidermal growth factor receptor (<i>EGFR</i>) mutations; characterize the clinical and imageological features of lung squamous cell carcinoma (LSCC) in a large population of patients; and assess correlations between clinical and imageological characteristics and clinical outcomes of LSCC patients harboring <i>EGFR</i> mutations. 31695493 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE The aim of this study was to evaluate the status of erlotinib treatment and EGFR mutation in lung SCC patients. 22420950 2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE We found EGFR-mutant LUAD showed significantly higher ITHi than KRAS-mutant LUAD/wild-type LUAD (P = 0.03) and numerically higher ITH than LUSC. 30626401 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE The EGFR-TKIs had a modest response for EGFR mutated lung squamous cell carcinoma patients and might be a selective option for those patients. 28881841 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE Epidermal growth factor receptor mutations and the clinical outcome in male smokers with squamous cell carcinoma of lung. 19543508 2009
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE A subsequent advanced SCC bearing EGFR L858R/T790M mutations occurred 3 years after surgery. 28272214 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE The Q787Q EGFR polymorphism allows stratifying lung squamous cell carcinoma patients and could be an independent prognostic marker, particularly among those in stages I and II. 26999786 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease CLINVAR MEK inhibitors reverse resistance in epidermal growth factor receptor mutation lung cancer cells with acquired resistance to gefitinib. 23102728 2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR 		0.500 GeneticVariation disease BEFREE Significance of epidermal growth factor receptor gene mutations in squamous cell lung carcinoma. 21318227 2011