GpIIIa 1565T/C and homozygous MTHFR677C/T polymorphisms were higher in DVT patients compared with the control group (OR=6.65, 95% CI=3.09-14.30 and OR=4.08, 95% CI=1.35-12.38, respectively).
Thus, the aim of the present study is to determine the prevalence of FVL, MTHFR C677T and MTHFRA1298C gene polymorphisms in patients with DVT in central Iran.
Polymorphisms of the 677th site C/T in MTHFR gene for 101 patients with lower extremities deep venous thrombosis (DVT group) and 120 healthy subjects (control group) were detected by polymerase chain reaction with sequence-specific primers.
Moreover, the MTHFRrs1801133 polymorphism may be implicated in the development of deep vein thrombosis and pulmonary embolism, while the MTHFRrs1801131 polymorphism may contribute to the development of pulmonary embolism.
To determine prevalence of methylenetetrahydrofolate reductase (MTHFR) mutations in apparently healthy individuals residing in Mumbai and patients with deep vein thrombosis (DVT) and coronary artery disease (CAD) and to correlate these polymorphisms with homocysteine (Hcy) levels.