The area under ROC curve of TFPI-1 was 0.905 (95% CI, 0.842~0.967) or 0.828 (95% CI, 0.742~0.915) for predicting DVT or metastasis (<i>P</i> < 0.001, resp.).
Our results indicate the presence of potent repressor sequences between -1999 and -345 in the TFPI promoter and suggest that the TFPIT-287C promoter polymorphism might be a risk factor for DVT.
We conclude that patients suffering from acute deep venous thrombosis express significantly higher concentrations of tissue factor pathway inhibitor than patients without deep venous thrombosis.
These results provide evidence for a relationship between venous thrombosis and total TFPI level as a possible risk factor, whereas they do not support a link between DVT and mutations in the nine exons of the TFPI gene.