Interestingly, there were no common CNVs shared among the three subtypes: NFкBIA amplification was shared between LCNEC and LCC, while AKT2 amplification was shared between LCNEC and SCLC.
Total-Akt overexpression and "fluorescence in situ hybridization-positive" gene gain (defined as "amplification/high level polysomy") of AKT2 were more prevalent in small cell carcinoma.