Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1
0.400 AlteredExpression disease BEFREE Our findings suggest that TTF-1 promotes SCLC growth and contributes to neuroendocrine and antiapoptotic gene expression by partly coordinating with ASCL1. 31782890 2020
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1
0.400 Biomarker disease BEFREE The association between 103 SNPs in 58 ASCL1 target genes and the response to chemotherapy and survival of patients with SCLC were analyzed. 31691490 2020
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1
0.400 Biomarker disease BEFREE Pharmacological co-targeting of ASCL1 and IGF-1R results in markedly synergistic effects in ASCL1<sup>High</sup> SCLC in vitro and in mouse models. 31324758 2019
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1
0.400 AlteredExpression disease BEFREE This study aimed to investigate the expression of DLL3 and ASCL1 in resected SCLC samples using immunohistochemical analysis. 31068386 2019
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1
0.400 AlteredExpression disease BEFREE Several lines of evidence, from SCLC primary human tumours, patient-derived xenografts, cancer cell lines and genetically engineered mouse models, appear to be converging on a new model of SCLC subtypes defined by differential expression of four key transcription regulators: achaete-scute homologue 1 (ASCL1; also known as ASH1), neurogenic differentiation factor 1 (NeuroD1), yes-associated protein 1 (YAP1) and POU class 2 homeobox 3 (POU2F3). 30926931 2019
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1
0.400 AlteredExpression disease BEFREE Wnt11 controlled NE differentiation, cell proliferation, and E-cadherin expression under the regulation of Ascl1 in SCLC cell lines. 31231131 2019
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1
0.400 GeneticVariation disease BEFREE Three correspond to known subtypes (SCLC-A, SCLC-N, and SCLC-Y), while the fourth is a previously undescribed ASCL1+ neuroendocrine variant (NEv2, or SCLC-A2). 31671086 2019
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1
0.400 AlteredExpression disease BEFREE In particular, the delta-like protein 3 (DLL3), a Notch inhibitory ligand whose expression is directly related to the key neuroendocrine transcription factor ASCL1, was found to be expressed in ~85% of SCLCs, while it exhibits minimal to absent surface expression in normal lungs. 30968324 2019
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1
0.400 AlteredExpression disease BEFREE Here, we found that exposure to the selective LSD1 inhibitor ORY-1001 activated the NOTCH pathway, resulting in the suppression of the transcription factor ASCL1 and the repression of SCLC tumorigenesis. 30723171 2019
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1
0.400 Biomarker disease BEFREE Amiloride inhibited growth of ASCL1-dependent SCLC more strongly than ASCL1-independent SCLC in vitro and slowed growth of ASCL1-driven SCLC in xenografts. 29413762 2018
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1
0.400 Biomarker disease BEFREE Our findings shine light on a regulatory axis in SCLC consisting of ASCL1/TTF-1/NFIB that potentially contributes to the tumourigenesis of SCLC. 29876935 2018
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1
0.400 Biomarker disease BEFREE IMPDH inhibition reduced RNA polymerase I-dependent expression of pre-ribosomal RNA and potently suppressed ASCL1<sup>Low</sup> cell growth in culture, selectively reduced growth of ASCL1<sup>Low</sup> xenografts, and combined with chemotherapy to improve survival in genetic mouse models of ASCL1<sup>Low</sup>/MYC<sup>High</sup> SCLC. 30043754 2018
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1
0.400 AlteredExpression disease BEFREE The proneural factor, ASCL1, was specifically up-regulated in SCLC which is known to have a neuroendocrine phenotype. 29866045 2018
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1
0.400 Biomarker disease BEFREE In a case-control cohort matched for basic clinical factors, expression of ProGRP, synaptophysin, chromogranin A, and ASCL1 was significantly decreased in TTF-1-negative SCLC samples. 29787820 2018
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1
0.400 AlteredExpression disease BEFREE The Shh signaling pathway activates INSM1 expression through N-myc and Ascl1 in aggressive SCLC. 29501727 2018
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1
0.400 AlteredExpression disease BEFREE Nuclear ASCL1 expression was present in SCLC but absent or barely present in adenocarcinoma in 7 cases. 30429033 2018
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1
0.400 Biomarker disease BEFREE On the other hand, achaete-scute complex homologue 1 (ASCL1), negatively regulated by Notch signaling, is a lineage-specific gene of SCLC, and functions to promote neuroendocrine differentiation as well as EMT. 27785690 2017
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1
0.400 AlteredExpression disease BEFREE High expression of the inhibitory Notch ligand Delta-like protein 3 (DLL3) in most SCLCs has been linked to expression of Achaete-scute homologue 1 (ASCL1; also known as ASH-1), a key transcription factor driving SCLC oncogenesis; encouraging preclinical and clinical activity has been demonstrated for an anti-DLL3-antibody-drug conjugate. 28534531 2017
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1
0.400 Biomarker disease BEFREE In addition, we also observed ASCL1 governed functional networks that are distinct to glioma and SCLC. 28742165 2017
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1
0.400 Biomarker disease BEFREE Together, ASCL1 and NEUROD1 distinguish heterogeneity in SCLC with distinct genomic landscapes and distinct gene expression programs. 27452466 2016
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1
0.400 AlteredExpression disease BEFREE Forced expression of the INSM1 gene in adenocarcinoma cell lines (H358 and H1975) induced the expression of ASCL1, brain-2 (BRN2), chromogranin A, synaptophysin, and neural cell adhesion molecule 1; in contrast, knockdown of the INSM1 gene by siRNA in SCLC (H69 and H889) decreased their expression. 26482608 2015
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1
0.400 Biomarker disease CTD_human The importance of ASCL1 as a potential driver oncogene in SCLC is further underscored by the observation that ASCL1 is overexpressed in >50% of SCLC specimens, an extent greater than that observed for other putative oncogenes (MYC, MYCN, and SOX2) previously implicated in SCLC. 26253517 2015
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1
0.400 Biomarker disease BEFREE The importance of ASCL1 as a potential driver oncogene in SCLC is further underscored by the observation that ASCL1 is overexpressed in >50% of SCLC specimens, an extent greater than that observed for other putative oncogenes (MYC, MYCN, and SOX2) previously implicated in SCLC. 26253517 2015
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1
0.400 AlteredExpression disease BEFREE We determined that achaete-scute homolog 1 (ASCL1), a transcription factor required for proper development of pulmonary neuroendocrine cells, is essential for the survival of a majority of lung cancers (both SCLC and NSCLC) with neuroendocrine features. 25267614 2014
Entrez Id: 429
Gene Symbol: ASCL1
ASCL1
0.400 Biomarker disease BEFREE These findings suggest that BRN2 is a higher level regulator than ASCL1 and ND1 and BRN2 might be involved in aggressiveness of SCLC. 23530560 2013