| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | Valproic acid (VPA) as a HDAC inhibitor was found to suppress SCLC cell growth and cell cycle arrest at phase G1, and observed to decrease HDAC4 and increase acetylation of histone H4 (AcH4) while activating Notch signalling with an increase of Notch1, Notch target gene HES1 and p21. | 29511449 | 2018 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Histone deacetylation around the promoter region of Notch1 inhibits Notch1 protein expression in SCLC and the restoration of Notch1 expression in SCLC leads to the concurrent appearance of epithelial-like areas within the SCLC, which could provide a possible mechanism for histogenesis of cSCLC. | 28414324 | 2017 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | In this study, we evaluated the expression of Notch1 and Numb in SCLC. | 28060745 | 2017 | ||||
|
0.080 | Biomarker | disease | BEFREE | Notch1 can enhance cell adhesion by induction of E-cadherin in SCLC, which indicates mesenchymal to epithelial transition. | 27785690 | 2017 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | Our study might indicate that rs312599 in Notch1 may be a novel biomarker for SCLC risk in Chinese non-smoking females. | 28415716 | 2017 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Furthermore, we found that INSM1 was not expressed in non-small-cell lung cancer and some SCLC cell lines expressing Notch1-Hes1. | 26482608 | 2015 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Notch1 up regulation has an inhibitory effect on cell growth and NE differentiation in SCLC, with induction of an epithelial-like morphology of cells in tissue samples. | 24888228 | 2014 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | Notch1 controls cell adhesion and EMT.Overexpression of Notch1 in SCLC switched off EMT, cell motility and cell metastatic potential. | 25456735 | 2014 |