Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 GeneticVariation disease BEFREE KRAS exon 3 mutation was found in 4 (21%) SCLC patients, and PTEN exon 7 mutation in only 1 (5%) SCLC patient. 31209806 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker disease BEFREE Treatment with everolimus decreases MCL-1 in colorectal carcinomas and small cell lung cancer (SCLC) cells but not glioblastoma multiforme (GBM) cells with a PTEN mutational background. 30201826 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 GeneticVariation disease BEFREE Several mechanisms for this acquired resistance have been identified, including development of an EGFR T790M mutation, MET amplification, hepatocyte growth factor overexpression, loss of phosphatase and tensin homolog expression, epithelial-mesenchymal transition, and transformation to small cell lung cancer. 28786540 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 GeneticVariation disease BEFREE Our analysis identified several genes with relatively low mutation frequency, including PTEN, as highly significant (p < 0.001), suggesting these genes may play an important role in the progression of SCLC. 29025592 2017
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 GeneticVariation disease BEFREE PTEN M264I mutation was identified only in a TKI-refractory lesion with SCLC transformation, while PIK3CA and RB1 mutations were identified only in pre-treatment primary tumour samples. 26400668 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker disease BEFREE In comparison to the carcinoids, LCNEC/SCLC tumors presented a stronger loss of nuclear and cytosolic PTEN associated with a loss of PTEN and p53. 25884169 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 GeneticVariation disease BEFREE In SCLCs with PTEN loss, PF-4989216 also inhibited PI3K signaling but did not induce BCL2-interacting mediator (BIM)-mediated apoptosis nor was there any effect on cell viability or transformation. 24240111 2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker disease BEFREE The ability of PTEN inactivation to accelerate SCLC in a genetic mouse model suggests that targeting the PTEN pathway is a therapeutic option for a subset of human patients with SCLC. 24482365 2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker disease BEFREE In this report, we examined the combined antitumor effect of adenovirus-mediated PTEN (AdVPTEN) gene therapy and DDP chemotherapy on PTEN-null NCI-H446 human SCLC cells in vitro and in vivo in athymic BALB/c nude mice. 23470565 2013
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker disease CTD_human Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. 22941188 2012
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 Biomarker disease BEFREE We investigated whether mutations of PTEN/MMAC1 play an important role in SCLC tumorigenesis. 9467947 1998
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.500 GeneticVariation disease BEFREE These data indicate that PTEN/MMAC1 mutations contribute to the pathogenesis and neoplastic evolution in SCLC but not in NSCLC. 9696041 1998