Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7249
Gene Symbol: TSC2
TSC2 		0.400 Biomarker disease CTD_human Somatic Mutations in TSC1 and TSC2 Cause Focal Cortical Dysplasia. 28215400 2017
Entrez Id: 7248
Gene Symbol: TSC1
TSC1 		0.400 Biomarker disease CTD_human Somatic Mutations in TSC1 and TSC2 Cause Focal Cortical Dysplasia. 28215400 2017
Entrez Id: 7249
Gene Symbol: TSC2
TSC2 		0.400 Biomarker disease CTD_human Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex. 21062901 2011
Entrez Id: 348980
Gene Symbol: HCN1
HCN1 		0.400 Biomarker disease CTD_human Increased seizure severity and seizure-related death in mice lacking HCN1 channels. 20384728 2010
Entrez Id: 2593
Gene Symbol: GAMT
GAMT 		0.400 Biomarker disease CTD_human Guanidinoacetate methyltransferase deficiency identified in adults and a child with mental retardation. 15651030 2005
Entrez Id: 7249
Gene Symbol: TSC2
TSC2 		0.400 Biomarker disease HPO
Entrez Id: 7248
Gene Symbol: TSC1
TSC1 		0.400 Biomarker disease HPO
Entrez Id: 2593
Gene Symbol: GAMT
GAMT 		0.400 Biomarker disease HPO
Entrez Id: 348980
Gene Symbol: HCN1
HCN1 		0.400 Biomarker disease HPO
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.320 Biomarker disease BEFREE In adult offspring at 90 days of age, circulating proinflammatory cytokines IL-1β and IL-6 were increased under CPS conditions. 31244775 2019
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.320 Biomarker disease BEFREE IL-6 concentrations were significantly higher at the 3h and 6h time point after tonic-clonic seizures (TCS) compared to the situation with simple partial and complex partial seizures. 29273305 2018
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.320 Biomarker disease CTD_human Expression profiles of hippocampal regenerative sprouting-related genes and their regulation by E-64d in a developmental rat model of penicillin-induced recurrent epilepticus. 23266720 2013
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.320 Biomarker disease BEFREE Previous studies indicate that ApoE ɛ4 is associated with several disease-related traits including the increased risk of late posttraumatic seizures, earlier onset of TLE, refractory complex partial seizures, and postictal confusion. 20810250 2010
Entrez Id: 348
Gene Symbol: APOE
APOE 		0.320 GeneticVariation disease BEFREE The aim of this research was to investigate the possible association of ApoE gene polymorphism with the development of resistance to pharmacological therapy in patients with partial complex seizures with or without secondary generalization. 16202217 2005
Entrez Id: 3569
Gene Symbol: IL6
IL6 		0.320 Biomarker disease CTD_human Profound increase in sensitivity to glutamatergic- but not cholinergic agonist-induced seizures in transgenic mice with astrocyte production of IL-6. 12836160 2003
Entrez Id: 2166
Gene Symbol: FAAH
FAAH 		0.310 Biomarker disease BEFREE CPS significantly inhibited hepatic carboxylesterase and fatty acid amide hydrolase and this inhibition was significantly greater in high fat fed animals. 29935250 2018
Entrez Id: 43
Gene Symbol: ACHE
ACHE 		0.310 AlteredExpression disease BEFREE Exposure to CPS significantly decreased red blood cell acetylcholinesterase (AChE) activity, but not brain AChE activity, in both diet groups. 29097212 2017
Entrez Id: 43
Gene Symbol: ACHE
ACHE 		0.310 Therapeutic disease CTD_human HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants. 27083141 2016
Entrez Id: 43
Gene Symbol: ACHE
ACHE 		0.310 Biomarker disease CTD_human HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants. 27083141 2016
Entrez Id: 2166
Gene Symbol: FAAH
FAAH 		0.310 Therapeutic disease CTD_human Enhancement of endocannabinoid signaling protects against cocaine-induced neurotoxicity. 25933444 2015
Entrez Id: 1244
Gene Symbol: ABCC2
ABCC2 		0.310 GeneticVariation disease BEFREE Linkage disequilibrium between polymorphisms of ABCB1 and ABCC2 to predict the treatment outcome of Malaysians with complex partial seizures on treatment with carbamazepine mono-therapy at the Kuala Lumpur Hospital. 23717663 2013
Entrez Id: 43
Gene Symbol: ACHE
ACHE 		0.310 Biomarker disease CTD_human Pilocarpine-induced seizures produce alterations on choline acetyltransferase and acetylcholinesterase activities and deficit memory in rats. 19941057 2010
Entrez Id: 43
Gene Symbol: ACHE
ACHE 		0.310 Therapeutic disease CTD_human Pilocarpine-induced seizures produce alterations on choline acetyltransferase and acetylcholinesterase activities and deficit memory in rats. 19941057 2010
Entrez Id: 1244
Gene Symbol: ABCC2
ABCC2 		0.310 Biomarker disease CTD_human Expression of the multidrug transporter MRP2 in the blood-brain barrier after pilocarpine-induced seizures in rats. 16504477 2006
Entrez Id: 116
Gene Symbol: ADCYAP1
ADCYAP1 		0.300 Biomarker disease CTD_human IL-6 knockout mice are protected from cocaine-induced kindling behaviors; possible involvement of JAK2/STAT3 and PACAP signalings. 29673861 2018