| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | AlteredExpression | disease | BEFREE | In the current study, we aimed to investigate the ex vivo immunomodulatory effect of cardamonin (C<sub>16</sub>H<sub>14</sub>O<sub>4</sub>), on pro-inflammatory cytokines, TNF-α, IL-6 and inducible nitric oxide synthase (iNOS) expression during pSS. | 29303022 | 2018 | ||||
|
0.070 | Biomarker | disease | BEFREE | Peripheral pSS monocytes produced significantly higher amounts of sBAFF and IL-6 than normal monocytes did, even in the absence of stimulation. | 22018243 | 2011 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | IL-6 expression was detected in the cytoplasm of inflammatory mononuclear cells and ductal epithelial cells and was enhanced in advanced stages of primary SS. | 18209090 | 2008 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | No association was found between IL-6 or IFNgamma polymorphisms and primary SS. | 14872501 | 2004 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | The G/C polymorphism of the IL6 gene does not predispose patients to pSS, but the circulating IL-6 concentration is related to specific manifestations of the disease and the levels of IL-6 are regulated by the IL6 promoter polymorphism in pSS. | 11426023 | 2001 | ||||
|
0.070 | Biomarker | disease | BEFREE | The pattern of cytokine mRNA expression in frozen minor salivary gland tissues from patients with primary Sjögren's syndrome (pSS) (n = 12) and controls (n = 8) using an in situ hybridization technique and oligonucleotide probes of interleukin-1 beta (IL-1 beta), tumour necrosis factor alpha and beta (TNF-alpha and TNF-beta), interleukin-6 (IL-6), interleukin-2 (IL-2) and its receptor (IL-2R), interleukin-4 (IL-4), interleukin-10 (IL-10), interferon-gamma (IFN-gamma) and transforming growth factor-beta (TGF-beta) was examined. | 7788146 | 1995 | ||||
|
0.070 | Biomarker | disease | BEFREE | The authors found the frequency of expression of HLA-DR (P < 0.0001), ICAM-1 (P < 0.035), and IL-6 (P < 0.0001) to be significantly elevated in patients with primary SS versus nondry eye control patients. | 8056525 | 1994 |