Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 338
Gene Symbol: APOB
APOB
0.100 GeneticVariation disease BEFREE This suggests that variation at the ApoB locus may be involved independently in the determination of serum lipid levels and in the development of ischaemic heart disease. 2452042 1988
Entrez Id: 3309
Gene Symbol: HSPA5
HSPA5
0.020 GeneticVariation disease BEFREE An epitope of Apolipoprotein B (ApoB), recognised by a monoclonal antibody BIP-45, is associated with the development of ischaemic heart disease (Duriez et al.1988). 2452042 1988
Entrez Id: 2662
Gene Symbol: GDF10
GDF10
0.010 GeneticVariation disease BEFREE An epitope of Apolipoprotein B (ApoB), recognised by a monoclonal antibody BIP-45, is associated with the development of ischaemic heart disease (Duriez et al.1988). 2452042 1988
Entrez Id: 3949
Gene Symbol: LDLR
LDLR
0.050 GeneticVariation disease BEFREE The increased incidence of ischemic heart disease in the Afrikaner population may in part be due to the high frequency of these two mutations in the LDL receptor gene. 2569482 1989
Entrez Id: 4878
Gene Symbol: NPPA
NPPA
0.310 Biomarker disease CTD_human Dipyridamole-induced myocardial ischaemia increases ANF release in man. 1830552 1991
Entrez Id: 338
Gene Symbol: APOB
APOB
0.100 GeneticVariation disease BEFREE We have examined DNA polymorphisms associated with the apolipoprotein B gene in 95 Sri Lankan males with ischaemic heart disease and 95 matched controls. 1674237 1991
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
0.090 GeneticVariation disease BEFREE Raised plasma levels of fibrinogen, factor VIIc, and plasminogen activator inhibitor-1 (PAI-1) are associated with an increased risk of ischemic heart disease. 1342288 1992
Entrez Id: 2147
Gene Symbol: F2
F2
0.040 AlteredExpression disease BEFREE Initially, a prospective analysis of factor VII antigen and prothrombin activity was performed in two groups of young subjects without symptoms who differed in their risk of ischemic heart disease based on a history (or lack thereof) of premature heart disease in a first-degree relative. 8245691 1993
Entrez Id: 7056
Gene Symbol: THBD
THBD
0.020 AlteredExpression disease BEFREE There was no difference in mean TM levels in subjects with and without electrocardiographic signs of ischaemic heart disease. 8392391 1993
Entrez Id: 308
Gene Symbol: ANXA5
ANXA5
0.220 Biomarker disease RGD Purification of cardiac annexin V from the beagle dog heart and changes in its localization in the ischemic rat heart. 8056721 1994
Entrez Id: 338
Gene Symbol: APOB
APOB
0.100 GeneticVariation disease BEFREE The heterogeneity of association of polymorphic alleles in the apolipoprotein B gene to complex traits like hypercholesterolemia and ischemic heart disease in this study could explain why in most studies the X+ allele has been associated with higher cholesterol levels, whereas the X- allele has been associated with symptomatic atherosclerosis. 8004802 1994
Entrez Id: 5972
Gene Symbol: REN
REN
0.060 Biomarker disease BEFREE These data point to the importance of the renin-angiotensin system in both ischemic heart disease and hypertension, even without increased circulating levels of plasma renin. 7898088 1994
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.390 AlteredExpression disease BEFREE In this study, cloned canine IL-6 cDNA was used as a molecular probe to study the regulation of IL-6 in an awake canine model of myocardial ischemia and reperfusion. 7671371 1995
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 GeneticVariation disease BEFREE Studies have shown an association of diabetic nephropathy and ischaemic heart disease with angiotensin converting enzyme gene polymorphism in subjects with diabetes. 8582133 1995
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 Biomarker disease BEFREE Results from SOLVD, SAVE, AIRE, GISSI-III, ISIS-IV, and the Chinese Captopril Trial suggest that therapy with ACE inhibitors, at least with enalapril, captopril, ramipril, and lisinopril, induce significant reduction in morbidity and mortality rates in patients with ischemic heart disease, myocardial infarction, and a wide range of ventricular function and myocardial infarction. 7585774 1995
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 GeneticVariation disease BEFREE The ACE genotype was not associated with the occurrence of either ischemic heart disease or myocardial infarction. 7854377 1995
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.400 Biomarker disease BEFREE Neovascularization stimulated by VEGF occurs in several important clinical contexts, including myocardial ischemia, retinal disease, and tumor growth. 8756616 1996
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.400 Biomarker disease BEFREE Another important finding was that TNF-alpha mRNA and TNF-alpha protein were present in the explanted hearts from DCM and IHD patients but not in nonfailing hearts. 8640999 1996
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.360 Biomarker disease BEFREE Interleukin-1 beta in coronary arteries of patients with ischemic heart disease. 8696938 1996
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
0.350 Biomarker disease BEFREE Alterations in circulating intercellular adhesion molecule-1 and L-selectin: further evidence for chronic inflammation in ischemic heart disease. 8701848 1996
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 Biomarker disease BEFREE The results of studies in humans looking more directly at the influence of ACE inhibitors on atherosclerosis and ischemic heart disease are awaited. 9115957 1996
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 GeneticVariation disease BEFREE The apolipoprotein epsilon4 allele and homozygous deletion allele (DD) of the angiotensin-converting enzyme gene are reported to be associated with an increase in the incidence of ischemic heart disease. 8641725 1996
Entrez Id: 2153
Gene Symbol: F5
F5
0.030 GeneticVariation disease BEFREE Factor V Leiden polymorphism (FV Q506) in patients with ischaemic heart disease, and in different populations groups. 8872815 1996
Entrez Id: 7133
Gene Symbol: TNFRSF1B
TNFRSF1B
0.020 Biomarker disease BEFREE We examined mRNA and protein levels for TNFR1, TNFR2, and TNF-alpha in explanted hearts from organ donors as well as in patients with end-stage dilated cardiomyopathy (DCM) and ischemic heart disease (IHD). 8640999 1996
Entrez Id: 3308
Gene Symbol: HSPA4
HSPA4
0.010 Biomarker disease BEFREE In conclusion, our results demonstrate the feasibility of using adenoviral vectors to overexpress the hsp70 in myogenic cells, specially in cardiomyocytes, and the efficiency of this approach for providing protection against myocardial ischemia. 9004152 1996