Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 25831
Gene Symbol: HECTD1
HECTD1
0.010 Biomarker disease BEFREE <b>Conclusion</b>: Our results suggest a critical role for circDLGAP4 and HECTD1 in endothelial cell dysfunction induced by I/R, providing novel insight into potential therapeutic targets for the treatment of myocardial ischaemia. 31607223 2020
Entrez Id: 23411
Gene Symbol: SIRT1
SIRT1
0.030 Biomarker disease BEFREE <b>Conclusion:</b> Our data indicated that exposure to GDM induced offspring cardiac oxidative stress and DNA hypermethylation, resulting in an epigenetic down-regulation of Sirt1 gene and aberrant development of heart ischemia-sensitive phenotype, which suggests that Sirt 1-mediated signaling is the potential therapeutic target for the heart ischemic disease in offspring. 31223283 2019
Entrez Id: 100126351
Gene Symbol: MIR939
MIR939
0.010 Biomarker disease BEFREE <b>Conclusions:</b> Exosomes derived from patients with myocardial ischemia promote angiogenesis via the miR-939-iNOS-NO pathway. 29721064 2018
Entrez Id: 1557
Gene Symbol: CYP2C19
CYP2C19
0.020 GeneticVariation disease BEFREE <i>CYP2C19*3</i> allele showed significant association with clopidogrel high on treatment reactivity in IHD patients. 31591927 2019
Entrez Id: 25928
Gene Symbol: SOSTDC1
SOSTDC1
0.010 Biomarker disease BEFREE 163 women with signs and symptoms of IHD and no obstructive CAD from the NHLBI- Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction (WISE-CVD) study underwent coronary reactivity testing with a Doppler flow wire (FloWire® Volcano, San Diego, CA) in the proximal left anterior descending artery. 28207868 2017
Entrez Id: 23410
Gene Symbol: SIRT3
SIRT3
0.050 Biomarker disease BEFREE 3-Bromo-4,5-Dihydroxybenzaldehyde Protects Against Myocardial Ischemia and Reperfusion Injury Through the Akt-PGC1α-Sirt3 Pathway. 30042676 2018
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.390 Biomarker disease CTD_human Myocardial ischemia induces interleukin-6 and tissue factor production in patients with coronary artery disease: a dobutamine stress echocardiography study. 16286589 2005
Entrez Id: 2152
Gene Symbol: F3
F3
0.320 Biomarker disease CTD_human Myocardial ischemia induces interleukin-6 and tissue factor production in patients with coronary artery disease: a dobutamine stress echocardiography study. 16286589 2005
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.240 AlteredExpression disease BEFREE Myocardial ischemia and reperfusion mouse model was used and Bcl-2 expression was assessed. 20307495 2010
Entrez Id: 3572
Gene Symbol: IL6ST
IL6ST
0.310 AlteredExpression disease BEFREE Cardiac ischemia-reperfusion regulates sympathetic neuropeptide expression through gp130-dependent and independent mechanisms. 21035185 2011
Entrez Id: 4827
Gene Symbol: NM
NM
0.010 AlteredExpression disease BEFREE Cardiac ischemia-reperfusion regulates sympathetic neuropeptide expression through gp130-dependent and independent mechanisms. 21035185 2011
Entrez Id: 10128
Gene Symbol: LRPPRC
LRPPRC
0.010 AlteredExpression disease BEFREE Cardiac ischemia-reperfusion regulates sympathetic neuropeptide expression through gp130-dependent and independent mechanisms. 21035185 2011
Entrez Id: 4153
Gene Symbol: MBL2
MBL2
0.030 Biomarker disease BEFREE Myocardial ischemia/reperfusion in MBL2 KI mice revealed that 3F8 preserved cardiac function and decreased infarct size and fibrin deposition in a time-dependent manner. 25482922 2015
Entrez Id: 1984
Gene Symbol: EIF5A
EIF5A
0.010 AlteredExpression disease BEFREE Myocardial ischemia/reperfusion (but not ischemia alone) markedly increased the plasma levels of eIF5A, and treatment with anti-eIF5A neutralizing mAbs significantly reduced myocardial injury. 26348594 2015
Entrez Id: 22926
Gene Symbol: ATF6
ATF6
0.010 Biomarker disease BEFREE Myocardial ischemia induces the ER stress response; however, neither the function of this response nor whether it is mediated by ATF6 is known. 27932512 2017
Entrez Id: 2065
Gene Symbol: ERBB3
ERBB3
0.010 AlteredExpression disease BEFREE Myocardial ischemia/reperfusion upregulates the transcription of the Neuregulin1 receptor ErbB3, but only postconditioning preserves protein translation: Role in oxidative stress. 28162790 2017
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.560 AlteredExpression disease BEFREE Myocardial ischemia-reperfusion enhances transcriptional expression of endothelin-1 and vasoconstrictor ETB receptors via the protein kinase MEK-ERK1/2 signaling pathway in rat. 28323857 2017
Entrez Id: 1910
Gene Symbol: EDNRB
EDNRB
0.030 AlteredExpression disease BEFREE Myocardial ischemia-reperfusion enhances transcriptional expression of endothelin-1 and vasoconstrictor ETB receptors via the protein kinase MEK-ERK1/2 signaling pathway in rat. 28323857 2017
Entrez Id: 494336
Gene Symbol: MIR424
MIR424
0.010 Biomarker disease BEFREE Myocardial ischemia/reperfusion (MI/R) causes loss of cardiomyocytes via oxidative stress-induced cardiomyocyte apoptosis. miR322, orthologous to human miR-424, was identified as an ischemia-induced angiogenic miRNA, but its cellular source and function in the setting of acute MI/R remains largely unknown. 31150734 2019
Entrez Id: 9622
Gene Symbol: KLK4
KLK4
0.010 Biomarker disease BEFREE Kallikrein gene delivery attenuates myocardial infarction and apoptosis after myocardial ischemia and reperfusion. 10642270 2000
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.100 AlteredExpression disease BEFREE ACE gene expression in the left ventricle varied with ACE genotype and LV function in IHD patients undergoing CABG. 10938484 2000
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
0.320 Biomarker disease BEFREE IGFBP-3 appeared to be more abundant in the heart than in the liver and in the failing hearts from patients with ischemic heart disease than in those with hypertrophic cardiomyopathy. 11194704 2000
Entrez Id: 133
Gene Symbol: ADM
ADM
0.010 Biomarker disease BEFREE Adrenomedullin seems to be involved in the pathophysiology of many diseases, including ischemic heart diseases, inflammatory diseases, tumors, and even eye diseases. 11318031 2001
Entrez Id: 59272
Gene Symbol: ACE2
ACE2
0.020 Biomarker disease BEFREE ACE2 deficiency impairs cardiac contractility and upregulates hypoxia-induced genes, suggesting a link with myocardial ischaemia. 15671045 2005
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.350 AlteredExpression disease LHGDN Adiponectin is an adipose-derived cytokine, and it is suggested that hypoadiponectinemia increases the prevalence of ischemic heart disease (IHD). 15877296 2005