Genetically predicted coffee consumption was not associated with T2DM (odds ratio (OR) 1.02, 95% confidence interval (CI) 0.76 to 1.36), depression (0.89, 95% CI 0.66 to 1.21), Alzheimer's disease (1.17, 95% CI 0.96 to 1.43), IHD (0.96, 95% CI 0.80 to 1.14), lipids, glycemic traits, adiposity or adiponectin.
Instead HOMA-IR and adiponectin appeared independently associated both to de novo IHD (OR 9.6*10<sup>13</sup>; 95% CI 3.026-3.08*10<sup>27</sup>; p = 0.042 and OR 0.206; 95% CI 0.053-0.796; p = 0.000, respectively) and overall new PCI (OR 1.5*10<sup>11</sup>; 95% CI 2.593-8.68*10<sup>21</sup>; p = 0.042 and OR 0.206; 95% CI 0.053-0.796; p = 0.000, respectively).
Reciprocal effects of systemic inflammation and brain natriuretic peptide on adiponectin biosynthesis in adipose tissue of patients with ischemic heart disease.