Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.560 Biomarker disease BEFREE There is much evidence to suggest that endothelin-1 might be involved in the pathogenesis of hypertension, atherosclerosis, and ischemic heart disease. 10192234 1999
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.550 Biomarker disease BEFREE Recent studies have indicated that monocyte chemoattractant protein-1 (MCP-1) plays an important role in the initiation and progression of ischaemic heart disease. 31077149 2019
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.550 GeneticVariation disease BEFREE Odds ratios (OR) with 95% confidence interval (CI) were used to evaluate the strength of associations between the MCP-1 A-2518G polymorphism (rs1024611) and IHD and IS susceptibilities. 25413568 2015
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.550 GeneticVariation disease BEFREE Decreased insulin-like growth factor-I (IGF-I) levels in adults have been associated with an increased risk of ischemic heart disease and heart failure. 21664162 2011
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.550 AlteredExpression disease BEFREE Several reports have suggested that low baseline levels of IGF1 increase the risk of fatal ischemic heart disease. 21039458 2010
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.550 GeneticVariation disease BEFREE The aim of our work was to find if MCP-1 -2518 (A/G) single nucleotide polymorphism (SNP) influences somehow the serum concentrations of high-sensitive CRP (hsCRP) both in patients suffering from ischemic heart disease (IHD), myocardial infarction (MI), angina pectoris (AP), and hypertension (HT) and in control group of healthy subjects. 19639050 2009
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.550 Biomarker disease RGD Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction. 16698918 2006
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.550 Biomarker disease BEFREE However, the gene expression changes caused by signal transduction, triggered by MCP-1 binding to its receptor CCR2, and their possible role in the development of IHD are not understood. 16574901 2006
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.550 Biomarker disease CTD_human Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study. 16214533 2005
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.550 Biomarker disease RGD Prolonged cold ischemia in rat cardiac allografts promotes ischemia-reperfusion injury and the development of graft coronary artery disease in a linear fashion. 16297799 2005
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.550 Biomarker disease CTD_human Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study. 16214533 2005
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.550 GeneticVariation disease BEFREE Our data demonstrate that, in an Irish population, the MCP-1 -2518G/A polymorphism is not strongly associated with IHD. 15245376 2004
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.550 AlteredExpression disease LHGDN We conclude that low baseline levels of IGF-I and IGFBP-1 increase the risk of fatal IHD among elderly men and women independent of prevalent IHD and CVD risk factors. 14715837 2004
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.550 Biomarker disease BEFREE Furthermore, it has been suggested that low IGF-I may increase the risk of IHD in otherwise healthy subjects. 14671411 2003
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
0.550 Biomarker disease BEFREE We conclude that gene transfer of IGF-I and IGF-II is a plausible strategy for the local delivery of IGFs to treat ischemic heart disease and heart failure by stimulating angiogenesis and protecting cardiomyocytes from cell death. 12505877 2003
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.550 Biomarker disease RGD Neutralization of MCAF/MCP-1 is beneficial by preventing reperfusion injury in a rat model of myocardial ischemia and reperfusion. 10068207 1999
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.520 Biomarker disease BEFREE This demonstration is the first showing that a physiologically inducible vector expressing of HO-1 genes improves the survival of stem cells in myocardial ischemia. 16198853 2005
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.520 Biomarker disease RGD Hyperglycemia in streptozotocin-induced diabetic rat increases infarct size associated with low levels of myocardial HO-1 during ischemia/reperfusion. 15734859 2005
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.520 Biomarker disease CTD_human Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study. 16214533 2005
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.520 Biomarker disease BEFREE The study population consisted of 1972 control subjects and 597 subjects with ischemic heart disease (myocardial infarction (MI) n = 393, HMOX1 n = 204). 15064108 2004
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
0.520 GeneticVariation disease LHGDN The study population consisted of 1972 control subjects and 597 subjects with ischemic heart disease (myocardial infarction (MI) n = 393, HMOX1 n = 204). 15064108 2004
Entrez Id: 3764
Gene Symbol: KCNJ8
KCNJ8
0.500 Biomarker disease RGD Effect of electronic stimulation at Neiguan (PC 6) acupoint on gene expression of adenosine triphosphate-sensitive potassium channel and protein kinases in rats with myocardial ischemia. 26591689 2015
Entrez Id: 3764
Gene Symbol: KCNJ8
KCNJ8
0.500 Biomarker disease CTD_human Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study. 16214533 2005
Entrez Id: 952
Gene Symbol: CD38
CD38
0.500 Biomarker disease CTD_human Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study. 16214533 2005
Entrez Id: 5534
Gene Symbol: PPP3R1
PPP3R1
0.500 Biomarker disease CTD_human Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study. 16214533 2005