Nrf2/Keap1/ARE is one of the essential signaling pathways that can attenuate myocardial infarct size and preserve cardiac function after myocardial ischemia and reperfusion injury (MIRI).
Mechanism of Emulsified Isoflurane Postconditioning-Induced Activation of the Nrf2-Antioxidant Response Element Signaling Pathway During Myocardial Ischemia-Reperfusion: The Relationship With Reactive Oxygen Species.