Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.600 Biomarker disease BEFREE Our results may provide a strong basis for studying the role of CRP and miRNAs in ischemic heart disease. 31063484 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.600 AlteredExpression disease BEFREE Univariate analysis revealed several short-term mortality-related predictors, including older age (OR 1.1, <i>P</i>=0.005), ischemic heart disease (OR 2, <i>P</i>=0.0197), higher creatinine level (OR 2.3, <i>P</i>=0.0043), and elevated CRP level and CRP-to-albumin ratio (OR 1.1, <i>P</i> < 0.0001; OR 1.0031, <i>P</i> < 0.0001, respectively). 31828049 2019
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.600 AlteredExpression disease BEFREE CRP also activated mPTP opening and reduced mitochondrial membrane potential during myocardial ischemia/reperfusion. 30364730 2018
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.600 Biomarker disease BEFREE The associations of serum n-6 polyunsaturated fatty acids with serum C-reactive protein in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. 29515239 2018
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.600 Biomarker disease BEFREE To test the hypothesis that the increased IHD risk because of obesity is mediated through lipoproteins, blood pressure, glucose, and C-reactive protein. 25411050 2015
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.600 Biomarker disease BEFREE Using a multidirectional mendelian randomization design, we investigated possible causal associations between the lipoproteins and C-reactive protein and between the lipoproteins and IHD. 23926208 2013
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.600 GeneticVariation disease BEFREE We describe a significant proportion of individual TS females having high levels of vWF, factor VIII, fibrinogen and CRP (15-40%) and an increased frequency of the Leiden mutation, with important associations with CIMT and blood pressure, suggesting that a subset of TS may have an unfavourable haemostatic balance, which may contribute to the increased risk of premature ischaemic heart disease and possibly increase the risk of deep venous and portal vein thrombosis. 21848660 2012
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.600 GeneticVariation disease BEFREE Multivariate analyses indicated that the strongest associations with IHD and MI were due to the combined effect of the VEGFA-2578 A allele and smoking (OR 3.52 and 7.11, respectively), independent of risk factors such as age, sex, diabetes, C-reactive protein, hypercholesterolemia, and hypertension. 21362767 2011
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.600 Biomarker disease RGD [Preliminary investigation of the changes and mechanism of Leptin after myocardial ischemia/reperfusion injury]. 21122204 2010
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.600 Biomarker disease BEFREE We hypothesized that the CYP2C9(*)2 (rs.1799853) and CYP2C9(*)3 (rs.1057910) polymorphisms with decreased enzyme activity affect risk of subclinical atherosclerosis (reduced ankle brachial index and increased C-reactive protein), ischemic vascular diseases (ischemic heart disease, myocardial infarction, ischemic cerebrovascular disease and ischemic stroke) and death after an ischemic heart disease diagnosis. 19652664 2009
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.600 GeneticVariation disease BEFREE Genotype combinations of the four CRP polymorphisms were associated with an increase in CRP levels of up to 64%, resulting in a theoretically predicted increased risk of up to 32% for ischemic heart disease and up to 25% for ischemic cerebrovascular disease. 18971492 2008
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.600 AlteredExpression disease BEFREE The identification of polymorphisms that determine basal CRP levels has implications in ischaemic heart disease, where CRP level is an important predictor of risk. 14645206 2004
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.600 Biomarker disease BEFREE The prevalence of C. pneumoniae DNA was not associated with age, gender, smoking, BMI, HDL, CRP, plasma creatinine and symptoms or signs of ischaemic heart disease. 14606608 2003
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.600 GeneticVariation disease BEFREE After multivariate regression adjustment for age, race/ethnicity, body mass index, and family history of early-onset ischemic heart disease, physical fitness remained inversely associated with CRP level in boys (beta = -0.02; standard error = 0.01). 12563060 2003
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.600 Biomarker disease CTD_human Persistent elevation of C-reactive protein and ischemic heart disease in patients with continuous ambulatory peritoneal dialysis. 11840375 2002
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.600 GeneticVariation disease BEFREE Because of the importance of the CRP gene product in inflammation and its recent association with ischemic heart disease syndromes, this polymorphism may be useful in the association studies of atherosclerosis and its related phenotypes. 10721674 2000
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.560 Biomarker disease BEFREE Endothelin-1 in hypertensive patients with ischemic heart disease. 31069633 2019
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.560 Biomarker disease BEFREE Interaction between Endothelin-1 and Left Stellate Ganglion Activation: A Potential Mechanism of Malignant Ventricular Arrhythmia during Myocardial Ischemia. 31214281 2019
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.560 Biomarker disease BEFREE We tested if two of those markers, endothelin-1 (ET-1) and growth differentiation factor 15 (GDF-15), can be used as immunohistochemical markers for myocardial ischaemia/infarctions. 29151120 2018
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.560 AlteredExpression disease BEFREE Myocardial ischemia-reperfusion enhances transcriptional expression of endothelin-1 and vasoconstrictor ETB receptors via the protein kinase MEK-ERK1/2 signaling pathway in rat. 28323857 2017
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.560 GeneticVariation disease BEFREE Patients with ischemic heart disease (IHD) and previous MI showed a difference in the distribution of genotype G8002A for endothelin-1: allele G 0.718 and A 0.282 vs those without MI: allele G 0.882 and A 0.118, (p<0.05). 18442814 2008
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.560 Biomarker disease CTD_human The aim of this study was to characterize the myocardial ischemia after the intracoronary administration of endothelin-1, and compare it with that induced by coronary stenosis. 16306806 2005
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.560 Therapeutic disease RGD Ex vivo blockade of endothelin-1 inhibits graft coronary artery disease in a rodent cardiac allograft model. 11927217 2002
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.560 Biomarker disease CTD_human Endothelin-1 production is enhanced by rotenone, a mitochondrial complex I inhibitor, in cultured rat cardiomyocytes. 11707688 2001
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.560 Biomarker disease CTD_human Changes in endothelium-derived vascular regulatory factors during dobutamine-stress-induced silent myocardial ischemia in patients with Kawasaki disease. 10462014 1999