Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.500 GeneticVariation disease BEFREE TKI-resistant <i>ALK</i>-rearranged lung adenocarcinoma with secondary CTNNB1 p.S45V and tertiary ALK p.I1171N mutations. 31616196 2019
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.500 Biomarker disease BEFREE RFC3 induces epithelial‑mesenchymal transition in lung adenocarcinoma cells through the Wnt/β‑catenin pathway and possesses prognostic value in lung adenocarcinoma. 31661124 2019
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.500 AlteredExpression disease BEFREE Immunohistochemistry was performed, which demonstrated that TNKS, β-catenin and Myc proto-oncogene protein (c-Myc) proteins are positively expressed in lung adenocarcinoma tissue; this expression was significantly higher than that in normal adjacent non-carcinoma tissues. 29805633 2018
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.500 GeneticVariation disease BEFREE Using this analysis, we also revealed that five genes (TP53, EGFR, PTEN, RB1, KRAS, and CTNNB1) were somatically mutated in multiple homogeneous lung adenocarcinomas. 29525983 2018
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.500 AlteredExpression disease BEFREE At the molecular level, overexpression of SH2B1 resulted in the upregulation of the EMT markers, especially induced β-catenin accumulation and activated β-catenin signaling to promote LADC cell proliferation and metastasis, while silencing SH2B1 had the opposite effect. 29380446 2018
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.500 Biomarker disease BEFREE miRomics and Proteomics Reveal a miR-296-3p/PRKCA/FAK/Ras/c-Myc Feedback Loop Modulated by HDGF/DDX5/β-catenin Complex in Lung Adenocarcinoma. 28751441 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.500 Biomarker disease BEFREE The present study aimed to explore the effects of Wnt/β‑catenin and Sox2 signaling on the chemoresistance of cisplatin‑resistant lung cancer cells by assessing the effects of Sox2 on Wnt/β‑catenin signaling activity, cell migration, invasion and clonogenicity, and susceptibility to cisplatin in lung adenocarcinoma A549 cells and cisplatin-resistant A549/DDP cells. 28259951 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.500 Biomarker disease BEFREE This investigation offers confirmation that PRC1 is a prognostic and promising therapeutic biomarker for people with lung adenocarcinoma and takes on a key part in the activation of the Wnt/β-catenin pathway in lung adenocarcinoma development. 28646916 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.500 AlteredExpression disease BEFREE Mining available gene expression data sets allowed to observe that high co-expression levels of SCD1, β-catenin, YAP/TAZ and downstream targets have a strong negative prognostic value in lung adenocarcinoma. 28368399 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.500 AlteredExpression disease BEFREE Immunohistochemistry assay of tissue microarrays from patients with lung cancer indicated that both CBP and β-catenin were highly expressed in tumor tissues and predicted poor prognosis in lung adenocarcinoma patients. 29141249 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.500 AlteredExpression disease BEFREE In the present study, we demonstrated that hypoxia in lung adenocarcinoma cells can enhance Wnt signaling activity by stabilizing β-catenin and altering its localization into the nucleus. 28713928 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.500 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.500 Biomarker disease BEFREE Lung adenocarcinoma tissues derived from gefitinib-resistant patients displayed a tendency to accumulate β-catenin in the cytoplasm. 26268703 2015
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.500 AlteredExpression disease BEFREE Importantly, miR-483-5p levels are positively correlated with β-catenin expression, but are negatively correlated with the levels of RhoGDI1 and ALCAM in human lung adenocarcinoma. 24710410 2014
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.500 GeneticVariation disease CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968 2014
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.500 Biomarker disease BEFREE Over-expression of deubiquitinating enzyme USP14 in lung adenocarcinoma promotes proliferation through the accumulation of β-catenin. 23702845 2013
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.500 Biomarker disease BEFREE Primary human lung adenocarcinomas accumulate pY654-β-catenin and HIF1α. 23246962 2013
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.500 Biomarker disease BEFREE Nuclear LEF1/TCF4 correlate with poor prognosis but not with nuclear β-catenin in cerebral metastasis of lung adenocarcinomas. 23224985 2013
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.500 PosttranslationalModification disease BEFREE Dysregulation of the canonical Wnt pathway, characterized by increased levels of β-catenin and epigenetic silencing of negative regulators, has been reported in adenocarcinoma of the lung. 22016777 2011
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.500 Biomarker disease BEFREE In contrast, the TGF-beta, TNF-alpha, Src, Myc, E2F3, and beta-catenin pathways are inactive in lung adenocarcinomas. 17572360 2007
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.500 Biomarker disease BEFREE Lung adenocarcinoma associated with familial adenomatous polyposis. Clear cell carcinoma with beta-catenin accumulation accompanied by atypical adenomatous hyperplasia. 15660284 2005
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.500 GeneticVariation disease BEFREE Constitutive activation of the Wnt signaling pathway by CTNNB1 (beta-catenin) mutations in a subset of human lung adenocarcinoma. 11170292 2001
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.500 CausalMutation disease CGI