Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7048
Gene Symbol: TGFBR2
TGFBR2
0.610 GeneticVariation disease BEFREE A dominant negative mutation of transforming growth factor-beta receptor type II gene in microsatellite stable oesophageal carcinoma. 10789724 2000
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 AlteredExpression disease BEFREE Over-expression of epidermal growth factor receptor in esophageal cancer is associated with poor prognosis. 22555809 2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 GeneticVariation disease BEFREE Presently, the single nucleotide polymorphisms (SNPs) of EGFR/PLCE1 genes and their associations with EC survival remain unclear. 31209807 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 AlteredExpression disease BEFREE In this report, the effect of PYM on EGFR expression in human esophageal cancer cells and the therapeutic efficacy of the combination of PYM and cetuximab on esophageal cancer xenograft were investigated. 22311160 2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE These results indicated that miR-133a could inhibit the MEK/ERK pathway to promote cell apoptosis and enhance radio-sensitivity by targeting EGFR in EC.. 27933650 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE The selection of esophageal cancer patients for future studies with EGFR-TKIs based on the level of EGFR expression in their tumors or SCC histology should be considered. 16575012 2006
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 in human advanced esophageal carcinoma. 8988034 1997
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Results of this study suggest that anti-EGFR therapies should be investigated in prospective clinical trials in different settings in EGFR FISH-positive and, in particular, EGFR-amplified esophageal cancer. 28537764 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 AlteredExpression disease BEFREE In this study, we first evaluated EGFR gene and protein expression in 70 Chinese EC patient tumor samples collected during surgery. 28881608 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 AlteredExpression disease BEFREE Real-time quantitative polymerase chain reaction technology (RT-PCR) was used to detect the expression of VEGF, HER-2, and EGFR mRNA in esophageal squamous cancer tissue of 60 cases and 30 cases of VEGF, HER-2, and EGFR mRNA in esophageal cancer adjacent tissues, and analyze its relationship with clinicopathological features. 26099724 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 AlteredExpression disease BEFREE Thus, changes in gene copy number or level of expression of HER-I or c-myc DNA sequences may play an important role in the pathogenesis of esophageal cancer in this high-risk region. 2459070 1988
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE A ligand-based and enediyne-energized bispecific fusion protein targeting epidermal growth factor receptor and insulin-like growth factor-1 receptor shows potent antitumor efficacy against esophageal cancer. 28498434 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE The int-2 and erbB genes are amplified more frequently than any other genes in human esophageal cancer. 9316622 1997
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE We review six aspects of the research literature on esophageal cancer: epidemiology and etiology, epidermal growth factor receptor and related growth factor receptors, cell cycle regulatory proteins, transforming growth factor-beta/Smad proteins, mismatch repair genes, and other genes. 15622457 2005
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 AlteredExpression disease BEFREE Epidermal growth factor receptor (EGFR) is frequently overexpressed in esophageal carcinoma and its precursor lesions. 15520175 2004
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE We evaluated the antitumor effects of lapatinib, a dual tyrosine kinase inhibitor which simultaneously inhibits EGFR and HER2, 5-fluorouracil (5-Fu) alone and in combination on esophageal cancer cells. 22293713 2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 GeneticVariation disease BEFREE These data suggest that EGF-R and p53 mutation may be used as both outcome predictors and targets for molecular therapy for esophageal cancer. 14695149 2003
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 GeneticVariation disease BEFREE EGFR mutations in esophageal carcinoma are rare but do exist, and thus gefitinib could be included in esophageal cancer treatment regimens by selecting those patients who possess such mutations. 17142003 2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 AlteredExpression disease BEFREE Esophageal carcinoma cell line with high EGFR polysomy is responsive to gefitinib. 25070024 2014
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Expression and prognostic influence of NF-κB and EGFR in esophageal cancer. 26681028 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Nimotuzumab is a humanized monoclonal antibody against epidermal growth factor receptor (EGFR), the efficacy of nimotuzumab added to nCRT for esophageal cancer is uncertain. 31258850 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 AlteredExpression disease BEFREE Results indicated that PT shows more effective antitumor activity as compared with Pan both on EGFR-overexpressed KYSE-450 and KYSE-150 esophageal cancer cells, especially on KYSE-450 cells. 30596104 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 GeneticVariation disease BEFREE Mutations of EGFR and V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) have been identified in esophageal carcinoma, but corresponding Chinese data are limited. 21615826 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 GeneticVariation disease BEFREE EGFR intron-1 CA repeat polymorphism is a predictor of relapse and survival in complete resected only surgically treated esophageal cancer. 23377570 2014
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 AlteredExpression disease BEFREE Epidermal growth factor receptor overexpression in esophageal carcinoma. An immunohistochemical study correlated with clinicopathologic findings and DNA amplification. 8039107 1994