Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.300 Biomarker disease CTD_human
Entrez Id: 80199
Gene Symbol: FUZ
FUZ
0.300 Biomarker disease CTD_human
Entrez Id: 6862
Gene Symbol: TBXT
TBXT
0.300 Biomarker disease CTD_human
Entrez Id: 57822
Gene Symbol: GRHL3
GRHL3
0.300 Biomarker disease CTD_human Differential response of heterozygous curly-tail mouse embryos to vitamin A teratogenesis depending on maternal genotype. 6635991 1983
Entrez Id: 5077
Gene Symbol: PAX3
PAX3
0.300 Biomarker disease CTD_human Histological comparison of the effects of the splotch gene and retinoic acid on the closure of the mouse neural tube. 3293260 1988
Entrez Id: 5077
Gene Symbol: PAX3
PAX3
0.300 Therapeutic disease CTD_human Histological comparison of the effects of the splotch gene and retinoic acid on the closure of the mouse neural tube. 3293260 1988
Entrez Id: 57216
Gene Symbol: VANGL2
VANGL2
0.350 Biomarker disease CTD_human Cranial effects of retinoic acid in the loop-tail (Lp) mutant mouse. 2373757 1990
Entrez Id: 6497
Gene Symbol: SKI
SKI
0.300 Biomarker disease CTD_human Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial, patterning, and skeletal muscle development. 9284043 1997
Entrez Id: 6240
Gene Symbol: RRM1
RRM1
0.300 Biomarker disease CTD_human Ribonucleotide reductase subunit R1: a gene conferring sensitivity to valproic acid-induced neural tube defects in mice. 10716750 2000
Entrez Id: 2350
Gene Symbol: FOLR2
FOLR2
0.300 Biomarker disease CTD_human Arsenic-induced congenital malformations in genetically susceptible folate binding protein-2 knockout mice. 11749123 2001
Entrez Id: 4522
Gene Symbol: MTHFD1
MTHFD1
0.300 Biomarker disease CTD_human A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group. 12384833 2002
Entrez Id: 5077
Gene Symbol: PAX3
PAX3
0.300 Therapeutic disease CTD_human Oxidant regulation of gene expression and neural tube development: Insights gained from diabetic pregnancy on molecular causes of neural tube defects. 12739027 2003
Entrez Id: 5077
Gene Symbol: PAX3
PAX3
0.300 Biomarker disease CTD_human Effect of arsenite, maternal age, and embryonic sex on spina bifida, exencephaly, and resorption rates in the splotch mouse. 12854658 2003
Entrez Id: 5077
Gene Symbol: PAX3
PAX3
0.300 Therapeutic disease CTD_human Effect of arsenite, maternal age, and embryonic sex on spina bifida, exencephaly, and resorption rates in the splotch mouse. 12854658 2003
Entrez Id: 5077
Gene Symbol: PAX3
PAX3
0.300 Biomarker disease CTD_human Oxidant regulation of gene expression and neural tube development: Insights gained from diabetic pregnancy on molecular causes of neural tube defects. 12739027 2003
Entrez Id: 85416
Gene Symbol: ZIC5
ZIC5
0.300 Biomarker disease CTD_human Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives. 15136147 2004
Entrez Id: 7546
Gene Symbol: ZIC2
ZIC2
0.300 Biomarker disease CTD_human Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives. 15136147 2004
Entrez Id: 27443
Gene Symbol: CECR2
CECR2
0.300 Biomarker disease CTD_human CECR2, a protein involved in neurulation, forms a novel chromatin remodeling complex with SNF2L. 15640247 2005
Entrez Id: 2737
Gene Symbol: GLI3
GLI3
0.300 Biomarker disease CTD_human Exencephaly induction by valproic acid in the genetic polydactyly/arhinencephaly mouse, Pdn/Pdn. 16359493 2005
Entrez Id: 2348
Gene Symbol: FOLR1
FOLR1
0.300 Biomarker disease CTD_human Role of Folbp1 in the regional regulation of apoptosis and cell proliferation in the developing neural tube and craniofacies. 15800851 2005
Entrez Id: 4522
Gene Symbol: MTHFD1
MTHFD1
0.300 Biomarker disease CTD_human Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish population. 16552426 2006
Entrez Id: 1437
Gene Symbol: CSF2
CSF2
0.300 Therapeutic disease CTD_human Valproic acid-induced fetal malformations are reduced by maternal immune stimulation with granulocyte-macrophage colony-stimulating factor or interferon-gamma. 17075842 2006
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.300 Therapeutic disease CTD_human Valproic acid-induced fetal malformations are reduced by maternal immune stimulation with granulocyte-macrophage colony-stimulating factor or interferon-gamma. 17075842 2006
Entrez Id: 635
Gene Symbol: BHMT
BHMT
0.300 Biomarker disease CTD_human Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions. 17035141 2006
Entrez Id: 81839
Gene Symbol: VANGL1
VANGL1
0.310 Biomarker disease CTD_human Mutations in VANGL1 associated with neural-tube defects. 17409324 2007