Hypermethylated ZNF582 and PAX1 genes in oral epithelial cells collected by mouth rinse are effective biomarkers for the detection of oral dysplasia and oral cancer.
Hypermethylated ZNF582 and PAX1 genes in oral scrapings collected from cancer-adjacent normal oral mucosal sites are associated with aggressive progression and poor prognosis of oral cancer.
Among the five tested genes, methylated ZNF582 (ZNF582<sup>m</sup>) and PAX1 (PAX1<sup>m</sup>) were found to be appropriate biomarkers for oral dysplasia and oral cancers.