Tumor-derived supernatants may impair the function of tumor-infiltrating pDCs, which subsequently decreases the immune response of CD4<sup>+</sup> T cells in human oral cancer through TGF-β- and IL-10- dependent mechanisms.
Our findings support the point that IL-10 genetic polymorphisms may play essential role in identifying esophageal cancer, nasopharyngeal cancer and oral cancer at early stage.
We studied the association between the polymorphism in TGF-β1 (G to C polymorphism at codon 25 <+915>) and IL-10 (-1082 G/A, -819 C/T, and -592 C/A) and the risk of OC in patients (n = 162) and healthy controls (n = 118) in Taiwan.
The AG and GG genotypes of IL10A-1082G, together with smoking and areca chewing habits, synergistically contribute to individual susceptibility for oral cancer.
These findings suggest that the high expression G allele of the -1082A/G polymorphism of the inflammation and angiogenesis-related IL-10 is strongly associated with increased risk for oral cancer.