| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.090 | GeneticVariation | group | BEFREE | However, a borderline significant association was detected between <i>MTHFR</i> C677T polymorphism and a decreased oral cancer risk (homozygous model: OR=0.71, 95% CI=0.50-1.00) in hospital-based studies. | 28138253 | 2017 | ||||
|
0.090 | GeneticVariation | group | BEFREE | The goals of this study were to evaluate the association of three genotypic polymorphism (MTHFR C677T, MTHFR A1298C and CBS 844ins68) and oral cancer risk in southeastern Brazilians and evaluate the interactions between polymorphisms and clinical histopathological parameters. | 26749456 | 2016 | ||||
|
0.090 | GeneticVariation | group | BEFREE | These results suggest that MTHFR C677T polymorphism may play a role in oral cancer carcinogenesis in Asian population and heavy drinkers. | 24488626 | 2014 | ||||
|
0.090 | GeneticVariation | group | BEFREE | Our study suggested gene-environment interactions between high alcohol intake and the MTHFR 677TT genotype for elevated oral cancer risk, with a significant impact on multiple methylation of cancer-related genes. | 20940365 | 2011 | ||||
|
0.090 | GeneticVariation | group | BEFREE | MTHFR C677T genotype may have joint effects with smoking on oral carcinogenesis, and may be a useful biomarker for prediction and prognosis of oral cancer. | 21737671 | 2011 | ||||
|
0.090 | GeneticVariation | group | BEFREE | This study aimed to investigate the role of MTHFR polymorphisms on oral cancer susceptibility and its potential impact on the prognostic outcome. | 20923444 | 2011 | ||||
|
0.090 | GeneticVariation | group | BEFREE | We investigated whether the mutant methylenetetrahydrofolate reductase (MTHFR) increases risk for oral cancer. | 16365753 | 2006 | ||||
|
0.090 | Biomarker | group | BEFREE | Methylenetetrahydrofolate reductase is associated with pathogenesis of both thrombosis and oral cancer. | 16080493 | 2005 | ||||
|
0.090 | GeneticVariation | group | BEFREE | Folate intake, serum homocysteine and methylenetetrahydrofolate reductase (MTHFR) C677T genotype are not associated with oral cancer risk in Puerto Rico. | 11925474 | 2002 |