Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3159
Gene Symbol: HMGA1
HMGA1
0.520 Biomarker disease BEFREE Our work also suggests that targeting HMGA1 could be effective adjuvant therapy for more aggressive uterine cancers and provides compelling data for further preclinical studies. 27001612 2016
Entrez Id: 3159
Gene Symbol: HMGA1
HMGA1
0.520 Biomarker disease CTD_human Both drugs block anchorage-independent growth in high-grade human uterine cancer cells that overexpress HMGA1a (MES-SA cells). 18645019 2008
Entrez Id: 3159
Gene Symbol: HMGA1
HMGA1
0.520 Biomarker disease BEFREE Although a larger study is needed to confirm these results, HMGA1a may be a useful marker for aggressive human uterine cancers. 17483309 2007
Entrez Id: 3159
Gene Symbol: HMGA1
HMGA1
0.520 Biomarker disease MGD
Entrez Id: 580
Gene Symbol: BARD1
BARD1
0.320 GeneticVariation disease BEFREE Mutations in tumor-suppressor gene BARD1 have been found in inherited and spontaneous breast, ovarian and uterine cancers. 16152612 2006
Entrez Id: 580
Gene Symbol: BARD1
BARD1
0.320 GeneticVariation disease BEFREE Mutations in the BRCA1-associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers. 9425226 1998
Entrez Id: 580
Gene Symbol: BARD1
BARD1
0.320 GeneticVariation disease UNIPROT
Entrez Id: 3219
Gene Symbol: HOXB9
HOXB9
0.300 Biomarker disease CTD_human Endocrine disrupting chemical, bisphenol-A, induces breast cancer associated gene HOXB9 expression in vitro and in vivo. 27182052 2016
Entrez Id: 8314
Gene Symbol: BAP1
BAP1
0.300 Biomarker disease CTD_human Inference on germline BAP1 mutations and asbestos exposure from the analysis of familial and sporadic mesothelioma in a high-risk area. 25231345 2015
Entrez Id: 4088
Gene Symbol: SMAD3
SMAD3
0.300 Biomarker disease CTD_human A high concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells. 22228119 2012
Entrez Id: 3624
Gene Symbol: INHBA
INHBA
0.300 Biomarker disease CTD_human A high concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells. 22228119 2012
Entrez Id: 8842
Gene Symbol: PROM1
PROM1
0.300 Biomarker disease CTD_human CD133+ cancer stem cell-like cells derived from uterine carcinosarcoma (malignant mixed Müllerian tumor). 21919130 2011
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.300 Biomarker disease CTD_human K-ras mutations in lung tumors and tumors from other organs are consistent with a common mechanism of ethylene oxide tumorigenesis in the B6C3F1 mouse. 17325976 2007
Entrez Id: 1027
Gene Symbol: CDKN1B
CDKN1B
0.300 Biomarker disease CTD_human A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression. 16391232 2006
Entrez Id: 1440
Gene Symbol: CSF3
CSF3
0.300 Therapeutic disease CTD_human Phase II trial of paclitaxel in patients with soft-tissue sarcoma. 9774950 1998
Entrez Id: 4436
Gene Symbol: MSH2
MSH2
0.100 CausalMutation disease CLINVAR
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.040 GeneticVariation disease BEFREE Israeli BRCA1 or BRCA2 mutation carriers are at an increased risk for developing uterine cancer, especially serous papillary and sarcoma. 30489631 2019
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.040 GeneticVariation disease BEFREE Mortality reduction and cost-effectiveness of performing hysterectomy at the time of risk-reducing salpingo-oophorectomy for prophylaxis against serous/serous-like uterine cancers in BRCA1 mutation carriers. 28390820 2017
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.040 GeneticVariation disease BEFREE Risk of uterine cancer for BRCA1 and BRCA2 mutation carriers. 28802188 2017
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.040 GeneticVariation disease BEFREE Mutations in the BRCA1-associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers. 9425226 1998
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.030 Biomarker disease BEFREE In humans, a PMN gene signature correlated with improved survival in several cancer subtypes, including PTEN-deficient uterine cancer. 26678340 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.030 Biomarker disease BEFREE In vitro and in vivo therapeutic experiments were carried out using PTEN-mutated and PTEN-wild-type models of uterine cancer alone and in combination with chemotherapy. 25833835 2015
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.030 AlteredExpression disease BEFREE Thus, Pten and Pik3ca have distinct consequences on the activation of the phosphatidylinositol 3-kinase pathway in endometrial epithelium and are likely to affect other nonoverlapping cellular mechanisms involved in the development and progression of the most common type of uterine cancer. 25698082 2015
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.030 Biomarker disease BEFREE Inhibitors of the PI3K pathway are in clinical testing in patients with solid tumors, including uterine cancer. 21903247 2011
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
0.030 GeneticVariation disease BEFREE Mutations and amplifications of the PIK3CA gene are relatively infrequent in human cervical and endometrial cancers; however, PIK3CA gene alteration may still play a role in some subset of uterine cancers. 18180098 2008