Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.380 | GeneticVariation | disease | BEFREE | We also identify negative associations (odds ratio < 1) between mutational signatures and driver mutations, and here we examine the role of aging and cigarette smoke mutagenesis in the generation of driver mutations in IDH1 and KRAS in brain cancers and lung adenocarcinomas respectively. | 30412573 | 2018 | ||||
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0.380 | Biomarker | disease | BEFREE | There is mounting clinical evidence that the mutational status of cancer driver genes such as KRAS or IDH1 may influence the risk of venous thromboembolism in patients with colorectal, lung or brain cancers. | 29703472 | 2018 | ||||
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0.380 | GeneticVariation | disease | BEFREE | These findings indicate that ZX06 deserves further optimization as a lead compound for the treatment of patients with IDH1 mutated brain cancers. | 29290542 | 2018 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | Mutations in the isocitrate dehydrogenase 1 (IDH1) gene have been identified in a number of cancer types, including brain cancer. | 29849122 | 2018 | ||||
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0.380 | GeneticVariation | disease | BEFREE | These findings indicate that 3g deserves further optimization as a lead compound for the treatment of patients with IDH1 mutated brain cancers. | 29089260 | 2017 | ||||
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0.380 | GeneticVariation | disease | BEFREE | Mutations of the isocitrate dehydrogenase 1 and 2 genes (IDH1 and IDH2) are commonly found in primary brain cancers. | 22015945 | 2012 | ||||
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0.380 | GeneticVariation | disease | BEFREE | IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group. | 20160062 | 2010 | ||||
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0.380 | Biomarker | disease | BEFREE | Mutations in the enzyme cytosolic isocitrate dehydrogenase 1 (IDH1) are a common feature of a major subset of primary human brain cancers. | 19935646 | 2009 | ||||
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0.380 | CausalMutation | disease | CGI |