Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.070 GeneticVariation disease BEFREE Association of tumor necrosis factor α, interleukin 6, and interleukin 10 promoter polymorphism with proliferative diabetic retinopathy in type 2 diabetic subjects. 22105495 2012
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.070 GeneticVariation disease BEFREE The -308G>a polymorphism of the TNF gene is associated with proliferative diabetic retinopathy in Caucasian Brazilians with type 2 diabetes. 25634985 2015
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.060 GeneticVariation disease BEFREE The objective of the present study was to test for a possible association of five single nucleotide polymorphisms (SNPs) in the MMP-2 gene and two polymorphisms in the MMP-9 gene with proliferative diabetic retinopathy (PDR) and to determine their plasma levels. 18552985 2008
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.060 GeneticVariation disease BEFREE Angiotensin-converting enzyme gene polymorphism is associated with proliferative diabetic retinopathy: a meta-analysis. 19865794 2010
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.060 GeneticVariation disease BEFREE The present work was designed to evaluate the contribution of functional SNP-1562C>T of MMP-9 gene to the risk of proliferative diabetic retinopathy (PDR) in type 2 diabetes mellitus (T2DM) patients in north Indian Population. 28964682 2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.060 GeneticVariation disease BEFREE We investigated the relationship between advanced diabetic retinopathy (ADR) and an angiotensin-converting enzyme (ACE) gene polymorphism in subjects with type 2 diabetes and ADR, pre-proliferative (PrePDR) or proliferative diabetic retinopathy (PDR) without overt nephropathy. 11106834 2000
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.060 GeneticVariation disease BEFREE The object of the study was to investigate the share of the polymorphisms I/D ACE, endothelin 1 4127G/A and TNF-beta NcoI in the susceptibility to proliferative diabetic retinopathy (PDR) in non-insulin-dependent diabetes mellitus (NIDDM). 11399938 2001
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.060 GeneticVariation disease BEFREE To evaluate the relationship between the ACE insertion/deletion polymorphism and proliferative diabetic retinopathy in patients with type 1 diabetes of long duration. 10480521 1999
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.060 GeneticVariation disease BEFREE Neither the 4G/5G PAI-1 gene polymorphism nor the I/D ACE gene polymorphism contributed to the genetic susceptibility to diabetic retinopathy, either non-proliferative, proliferative or severe proliferative diabetic retinopathy, i.e. visual acuity of 0.1 or less in the better eye, in a group of Caucasian subjects with type 2 diabetes. 12660488 2003
Entrez Id: 2056
Gene Symbol: EPO
EPO
0.050 GeneticVariation disease BEFREE Recently, it was demonstrated that the T allele of SNP rs1617640 in the promoter of the erythropoetin (EPO) gene is significantly associated with proliferative diabetic retinopathy (PDR) and end-stage renal disease (ESRD) due to increased EPO expression. 21092038 2010
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.040 GeneticVariation disease BEFREE Association of monocyte chemoattractant protein-1 (MCP-1)2518A/G polymorphism with proliferative diabetic retinopathy in northern Chinese type 2 diabetes. 24809310 2014
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
0.040 GeneticVariation disease BEFREE The object of the study was to investigate the share of the polymorphisms I/D ACE, endothelin 1 4127G/A and TNF-beta NcoI in the susceptibility to proliferative diabetic retinopathy (PDR) in non-insulin-dependent diabetes mellitus (NIDDM). 11399938 2001
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.040 GeneticVariation disease BEFREE In the present study, we evaluated the association of a single nucleotide polymorphism (SNP) in the MCP-1 gene with proliferative diabetic retinopathy (PDR) in a Korean population with type 2 diabetes. 23549806 2013
Entrez Id: 5362
Gene Symbol: PLXNA2
PLXNA2
0.030 GeneticVariation disease BEFREE To evaluate the macular microvascular changes in eyes with proliferative diabetic retinopathy (PDR) following panretinal photocoagulation (PRP) METHODS: Using OCT angiography, we prospectively studied 10 eyes of 10 subjects with high risk PDR immediately before, 1 month and 3-6 months following PRP, using 3x3mm OCTA scan at each visit. 31078542 2019
Entrez Id: 5362
Gene Symbol: PLXNA2
PLXNA2
0.030 GeneticVariation disease BEFREE Observation of neovascularization of the disc associated with proliferative diabetic retinopathy using OCT angiography. 29460018 2018
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
0.030 GeneticVariation disease BEFREE The aim of the present investigation was to find possible association of new polymorphisms in bFGF with proliferative diabetic retinopathy (PDR) and determine the plasma level in PDR. 17997184 2008
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.030 GeneticVariation disease BEFREE The objective of the present study was to test for a possible association of five single nucleotide polymorphisms (SNPs) in the MMP-2 gene and two polymorphisms in the MMP-9 gene with proliferative diabetic retinopathy (PDR) and to determine their plasma levels. 18552985 2008
Entrez Id: 2247
Gene Symbol: FGF2
FGF2
0.030 GeneticVariation disease BEFREE Polymorphisms in the promoter region of the basic fibroblast growth factor gene and proliferative diabetic retinopathy in Caucasians with type 2 diabetes. 18279437 2008
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.020 GeneticVariation disease BEFREE Association of Pro12Ala polymorphism in peroxisome proliferator activated receptor gamma with proliferative diabetic retinopathy. 23559865 2013
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
0.020 GeneticVariation disease BEFREE Association of vascular endothelial growth factor, transforming growth factor beta, and interferon gamma gene polymorphisms with proliferative diabetic retinopathy in patients with type 2 diabetes. 23213275 2012
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.020 GeneticVariation disease BEFREE The 4a/4a genotype of the VNTR polymorphism for endothelial nitric oxide synthase (eNOS) gene predicts risk for proliferative diabetic retinopathy in Slovenian patients (Caucasians) with type 2 diabetes mellitus. 22311033 2012
Entrez Id: 3491
Gene Symbol: CCN1
CCN1
0.020 GeneticVariation disease BEFREE Here, we show that vitreal fluids from patients with proliferative diabetic retinopathy (PDR) were enriched with a two-module form of CCN1 comprising completely or partially the insulin-like growth factor-binding protein (IGFBP) and von Willebrand factor type C (vWC) domains. 23798676 2013
Entrez Id: 4846
Gene Symbol: NOS3
NOS3
0.020 GeneticVariation disease BEFREE Lack of association between an ecNOS gene polymorphism and diabetic nephropathy in type 2 diabetic patients with proliferative diabetic retinopathy. 10741691 2000
Entrez Id: 406938
Gene Symbol: MIR146A
MIR146A
0.010 GeneticVariation disease BEFREE This study aimed to investigate whether the single-nucleotide polymorphism (SNP) rs2910164 residing within microRNA-146a (miR-146a) is associated with diabetic microvascular complications diabetic nephropathy (DN), proliferative diabetic retinopathy (PDR) or diabetic macular oedema (DME) in either Caucasian patients with type 1 (T1DM) or type 2 (T2DM) diabetes mellitus. 26997512 2016
Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
0.010 GeneticVariation disease BEFREE Association of homozygous SDF-1 3'A genotype with proliferative diabetic retinopathy. 19381432 2010