|
SERPINE1
|
0.100 |
Biomarker
|
disease |
BEFREE |
Higher rise of PAI-1 within the first 24 h of acute myocardial infarction has been linked to some of its high-risk features.
|
30659821 |
2019 |
|
SERPINE1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The present study demonstrates that patients with AMI exhibit decreased miR-30b expression and elevated PAI-1 expression in the peripheral blood. miR-30b may therefore inhibit the damage to myocardial cells that occurs following AMI and protect myocardial cell function by targeting PAI-1 expression.
|
29805539 |
2018 |
|
SERPINE1
|
0.100 |
Biomarker
|
disease |
BEFREE |
PAI-1 produced in the infarcted myocardium and released into the coronary circulation is associated with endothelial dysfunction in resistance vessels of the infarct-related coronary arteries and with progressive dysfunction of the infarcted region of the left ventricle in AMI survivors.
|
26632165 |
2016 |
|
SERPINE1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We concluded that 4G/4G genotype and 4G allele of the PAI-1 gene are associated with risk of AMI and its morbidity.
|
25113642 |
2015 |
|
SERPINE1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
4G carriership of the polymorphism of PAI-1 was associated with lower risk for acute MI (odds ratio 0.45, 95% confidence interval 0.23-0.88, P = 0.02) after adjusting for major cardiovascular risk factors.
|
19844663 |
2010 |
|
SERPINE1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of the plasminogen activator inhibitor-1 gene 4G/5G polymorphism with ST elevation acute myocardial infarction in young patients.
|
19401121 |
2009 |
|
SERPINE1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Others have found that increased expression of PAI-1 is a risk factor for acute myocardial infarction.
|
18607173 |
2008 |
|
SERPINE1
|
0.100 |
Biomarker
|
disease |
BEFREE |
PAI-1 (p<0.001) but not nitrate was higher in AMI patients with low response to FMV.
|
17126309 |
2007 |
|
SERPINE1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study aimed to evaluate whether increase in the plasma PAI-1 antigen concentration or activity after fibrinolytic therapy in patients with acute myocardial infarction is associated with the -675 4G/5G genetic polymorphism in the promoter region of PAI-1 gene.
|
16706983 |
2006 |
|
SERPINE1
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Plasminogen activator inhibitor-1 4G/5G polymorphism and efficacy of reperfusion therapy in acute myocardial infarction.
|
16175011 |
2005 |
|
SERPINE1
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We have found no evidence that subjects with the 4G/4G polymorphism have higher PAI-1 levels on admission or 6 months after AMI.
|
12801613 |
2003 |
|
SERPINE1
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data offer a mechanistic link between inflammation and LV remodeling by demonstrating a heretofore unrecognized role for MPO and PAI-1 in orchestrating the myocardial response to AMI.
|
12615902 |
2003 |