| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | AlteredExpression | disease | BEFREE | Injection of exosomes isolated from AMI mice into wild-type mice downregulates CXCR4 expression in BM-MNCs and increases the number of circulating progenitor cells. | 30814518 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | We investigated the therapeutic potential and mode of action of the peptidic macrocycle CXCR4 antagonist POL5551 in mice with reperfused MI. | 30696265 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | And we demonstrated that Nestin<sup>+</sup>BMSC-secreted TIMP-1/2 enhances CXCL12(SDF1α)/CXCR4 axis-driven migration of endogenous Sca-1<sup>+</sup> endothelial cells in ischemic heart post-AMI. | 31029167 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | E2 can produce cardiovascular protective effects in AMI setting by enhancing homing and angiogenic capacity of EPCs through ERα and CXCR4 signaling pathways, which means that ERα and CXCR4 pathways are effective targets for the development of treatment strategies for AMI. | 30371725 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | We speculated that a specific CXCR4 ligand, [<sup>68</sup>Ga]pentixafor, along with novel techniques for motion correction, would facilitate the in vivo characterization of CXCR4 expression in small culprit and nonculprit coronary atherosclerotic lesions after acute myocardial infarction by motion-corrected targeted PET/CT. | 29967943 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | The SDF-1:CXCR4 axis is compromised in diabetes, which appears to augment the deleterious consequences of AMI. | 29119710 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | PMSNs-siCCR2 (25 µg/g) were also intravenously injected via the tail vein immediately following AMI induction. | 26199646 | 2015 | ||||
|
0.080 | Biomarker | disease | BEFREE | SDF-1:CXCR4 has been shown to affect stem cell homing, cardiac myocyte survival and ventricular remodeling in animal studies of acute myocardial infarction and chronic heart failure. | 22673496 | 2012 |