In the infarcted myocardium, compared with sham animals, the MI group had higher level of IL-33, sST2, and IL-1β, as well as higher concentrations of markers of fibrosis and inflammation.
We investigated the relationship between pain during AMI and levels of circulating proinflammatory (tumor necrosis factor [TNF]-α, interleukin [IL]-6) and anti-inflammatory (IL-33 and tissue growth factor [TGF]-β1) cytokines.
These results may be helpful in identifying IL-33/ST2 systems as putative b-blocker targets at an early stage after AMI.(Cardiol J 2017; 24, 2: 188-194).