Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4088
Gene Symbol: SMAD3
SMAD3
0.120 Biomarker disease HPO
Entrez Id: 4000
Gene Symbol: LMNA
LMNA
0.110 Biomarker disease HPO
Entrez Id: 3081
Gene Symbol: HGD
HGD
0.100 Biomarker disease HPO
Entrez Id: 6687
Gene Symbol: SPG7
SPG7
0.100 CausalMutation disease CLINVAR
Entrez Id: 7421
Gene Symbol: VDR
VDR
0.100 GeneticVariation disease BEFREE Two intragenic polymorphisms of the vitamin D receptor gene revealed an association with disc degeneration. 9854746 1998
Entrez Id: 7421
Gene Symbol: VDR
VDR
0.100 GeneticVariation disease BEFREE Vitamin D receptor gene variations are associated with osteoporosis, osteoarthritis, and disc degeneration. 11224872 2001
Entrez Id: 176
Gene Symbol: ACAN
ACAN
0.100 Biomarker disease BEFREE In degeneration, there was evidence of a loss of aggrecan synthesis, which may contribute to the pathogenesis of disc degeneration. 11950957 2002
Entrez Id: 176
Gene Symbol: ACAN
ACAN
0.100 GeneticVariation disease BEFREE In addition, disc degeneration has been shown to be related to an aggrecan gene polymorphism, a vitamin D receptor and matrix metalloproteinase-3 gene alleles. 12014433 2002
Entrez Id: 7421
Gene Symbol: VDR
VDR
0.100 GeneticVariation disease BEFREE This study revealed that the Tt allele of the vitamin-D receptor gene was more frequently associated with multilevel and severe disc degeneration and disc herniation than was the TT allele, pointing to an increased risk of disc disease at an early age in subjects with the Tt allele in the vitamin-D receptor gene. 12429765 2002
Entrez Id: 1299
Gene Symbol: COL9A3
COL9A3
0.060 GeneticVariation disease BEFREE COL9A3 gene polymorphism and obesity in intervertebral disc degeneration of the lumbar spine: evidence of gene-environment interaction. 12461395 2002
Entrez Id: 4314
Gene Symbol: MMP3
MMP3
0.060 GeneticVariation disease BEFREE In addition, disc degeneration has been shown to be related to an aggrecan gene polymorphism, a vitamin D receptor and matrix metalloproteinase-3 gene alleles. 12014433 2002
Entrez Id: 7222
Gene Symbol: TRPC3
TRPC3
0.040 GeneticVariation disease BEFREE From 45% to 71% of disc degeneration among persistently obese individuals with the Trp3 allele could be attributed to the synergism of these two factors. 12461395 2002
Entrez Id: 7219
Gene Symbol: TRP-TGG3-1
TRP-TGG3-1
0.040 GeneticVariation disease BEFREE From 45% to 71% of disc degeneration among persistently obese individuals with the Trp3 allele could be attributed to the synergism of these two factors. 12461395 2002
Entrez Id: 7421
Gene Symbol: VDR
VDR
0.100 GeneticVariation disease BEFREE Tryptophan alleles in COL9A2 and COL9A3 have been shown to be associated with lumbar disc disease in the Finnish population, and polymorphisms in the vitamin D receptor gene (VDR) (FokI and TaqI), the matrix metalloproteinase-3 gene (MMP-3) and an aggrecan gene (AGC1) VNTR have been reported to be associated with disc degeneration. 14644861 2003
Entrez Id: 176
Gene Symbol: ACAN
ACAN
0.100 GeneticVariation disease BEFREE Tryptophan alleles in COL9A2 and COL9A3 have been shown to be associated with lumbar disc disease in the Finnish population, and polymorphisms in the vitamin D receptor gene (VDR) (FokI and TaqI), the matrix metalloproteinase-3 gene (MMP-3) and an aggrecan gene (AGC1) VNTR have been reported to be associated with disc degeneration. 14644861 2003
Entrez Id: 7421
Gene Symbol: VDR
VDR
0.100 GeneticVariation disease BEFREE Frequencies of T and t alleles of VDR did not correlate with disc degeneration, osteophyte formation, or osteoporosis. 12689684 2003
Entrez Id: 4314
Gene Symbol: MMP3
MMP3
0.060 GeneticVariation disease BEFREE Tryptophan alleles in COL9A2 and COL9A3 have been shown to be associated with lumbar disc disease in the Finnish population, and polymorphisms in the vitamin D receptor gene (VDR) (FokI and TaqI), the matrix metalloproteinase-3 gene (MMP-3) and an aggrecan gene (AGC1) VNTR have been reported to be associated with disc degeneration. 14644861 2003
Entrez Id: 1299
Gene Symbol: COL9A3
COL9A3
0.060 GeneticVariation disease BEFREE Tryptophan alleles in COL9A2 and COL9A3 have been shown to be associated with lumbar disc disease in the Finnish population, and polymorphisms in the vitamin D receptor gene (VDR) (FokI and TaqI), the matrix metalloproteinase-3 gene (MMP-3) and an aggrecan gene (AGC1) VNTR have been reported to be associated with disc degeneration. 14644861 2003
Entrez Id: 6662
Gene Symbol: SOX9
SOX9
0.050 Biomarker disease BEFREE These findings suggest a potential role for Sox9 gene therapy in the treatment of human degenerative disc disease. 12698117 2003
Entrez Id: 7076
Gene Symbol: TIMP1
TIMP1
0.040 Biomarker disease BEFREE To assess the potential of TIMP-1 to favorably modify the proteoglycan content of degenerated intervertebral disc cells. 14560079 2003
Entrez Id: 1298
Gene Symbol: COL9A2
COL9A2
0.040 GeneticVariation disease BEFREE Tryptophan alleles in COL9A2 and COL9A3 have been shown to be associated with lumbar disc disease in the Finnish population, and polymorphisms in the vitamin D receptor gene (VDR) (FokI and TaqI), the matrix metalloproteinase-3 gene (MMP-3) and an aggrecan gene (AGC1) VNTR have been reported to be associated with disc degeneration. 14644861 2003
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 Biomarker disease BEFREE To study the role of the interleukin-1 beta gene (IL1B) and the IL-1 receptor antagonist gene (IL1RN) in relation to the occurrence of radiographic osteoarthritis (ROA) in the hip, knee, and hand and disc degeneration of the spine. 15077300 2004
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 GeneticVariation disease BEFREE IL-1 gene cluster polymorphisms could affect the risk of disc degeneration. 15308963 2004
Entrez Id: 3552
Gene Symbol: IL1A
IL1A
0.080 GeneticVariation disease BEFREE IL-1 gene cluster polymorphisms could affect the risk of disc degeneration. 15308963 2004
Entrez Id: 3552
Gene Symbol: IL1A
IL1A
0.080 Biomarker disease BEFREE To study the role of the interleukin-1 beta gene (IL1B) and the IL-1 receptor antagonist gene (IL1RN) in relation to the occurrence of radiographic osteoarthritis (ROA) in the hip, knee, and hand and disc degeneration of the spine. 15077300 2004