Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 836
Gene Symbol: CASP3
CASP3 		0.040 Biomarker disease BEFREE Caspase 3 silencing inhibits biomechanical overload-induced intervertebral disk degeneration. 24389166 2014
Entrez Id: 9260
Gene Symbol: PDLIM7
PDLIM7 		0.010 Biomarker disease BEFREE LIM mineralization protein-1 suppresses TNF-α induced intervertebral disc degeneration by maintaining nucleus pulposus extracellular matrix production and inhibiting matrix metalloproteinases expression. 25336289 2015
Entrez Id: 2896
Gene Symbol: GRN
GRN 		0.030 Biomarker disease BEFREE Progranulin knockout accelerates intervertebral disc degeneration in aging mice. 25777988 2015
Entrez Id: 3553
Gene Symbol: IL1B
IL1B 		0.100 AlteredExpression disease BEFREE IL-1β is highly expressed in degenerative intervertebral disk (IVD) tissues and cells, and it has been shown to be involved in multiple pathological processes during disk degeneration, including inflammatory responses, matrix destruction, angiogenesis and innervation, cellular apoptosis, oxidative stress and cellular senescence. 26341894 2015
Entrez Id: 406910
Gene Symbol: MIR125A
MIR125A 		0.020 GeneticVariation disease BEFREE MiR-125a Rs12976445 Polymorphism is Associated with the Apoptosis Status of Nucleus Pulposus Cells and the Risk of Intervertebral Disc Degeneration. 26800505 2016
Entrez Id: 360
Gene Symbol: AQP3
AQP3 		0.010 Biomarker disease BEFREE Aquaporin 3 protects against lumbar intervertebral disc degeneration via the Wnt/β-catenin pathway. 26820815 2016
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1 		0.010 Biomarker disease BEFREE Heme oxygenase-1 attenuates IL-1β induced alteration of anabolic and catabolic activities in intervertebral disc degeneration. 26877238 2016
Entrez Id: 8045
Gene Symbol: RASSF7
RASSF7 		0.010 AlteredExpression disease BEFREE RASSF7 expression and its regulatory roles on apoptosis in human intervertebral disc degeneration. 26884887 2015
Entrez Id: 5595
Gene Symbol: MAPK3
MAPK3 		0.030 Biomarker disease BEFREE ERK1/2-mediated inflammatory pathway also plays a crucial role in the intervertebral disc degeneration. 27270637 2017
Entrez Id: 406949
Gene Symbol: MIR15B
MIR15B 		0.010 Biomarker disease BEFREE MiR-15b contributes to ECM degradation in intervertebral disc degeneration (IDD) via targeting of SMAD3, thus providing a novel therapeutic target for IDD treatment. 28039556 2017
Entrez Id: 655
Gene Symbol: BMP7
BMP7 		0.090 Biomarker disease BEFREE BMP-7/OP-1 has been shown to retard disc degeneration. 28102712 2017
Entrez Id: 51548
Gene Symbol: SIRT6
SIRT6 		0.020 Biomarker disease BEFREE Sirtuin 6 prevents matrix degradation through inhibition of the NF-κB pathway in intervertebral disc degeneration. 28215636 2017
Entrez Id: 59067
Gene Symbol: IL21
IL21 		0.010 Biomarker disease BEFREE IL-21 Is Positively Associated with Intervertebral Disc Degeneration by Interaction with TNF-α Through the JAK-STAT Signaling Pathway. 28233079 2017
Entrez Id: 50616
Gene Symbol: IL22
IL22 		0.010 Biomarker disease BEFREE IL-21 Is Positively Associated with Intervertebral Disc Degeneration by Interaction with TNF-α Through the JAK-STAT Signaling Pathway. 28233079 2017
Entrez Id: 9507
Gene Symbol: ADAMTS4
ADAMTS4 		0.050 AlteredExpression disease BEFREE ADAMTS-4 expression increased both in the TNF-α-induced nucleus pulposus cells and intervertebral disc degeneration rat model. 28512264 2017
Entrez Id: 9508
Gene Symbol: ADAMTS3
ADAMTS3 		0.040 AlteredExpression disease BEFREE ADAMTS-4 expression increased both in the TNF-α-induced nucleus pulposus cells and intervertebral disc degeneration rat model. 28512264 2017
Entrez Id: 11096
Gene Symbol: ADAMTS5
ADAMTS5 		0.040 Biomarker disease BEFREE ADAMTS5 Deficiency Protects Mice From Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration. 28570296 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B 		0.100 AlteredExpression disease BEFREE IL-1β increases asporin expression via the NF-κB p65 pathway in nucleus pulposus cells during intervertebral disc degeneration. 28646230 2017
Entrez Id: 406921
Gene Symbol: MIR132
MIR132 		0.010 AlteredExpression disease BEFREE MicroRNA-132 upregulation promotes matrix degradation in intervertebral disc degeneration. 28793234 2017
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10 		0.030 GeneticVariation disease BEFREE TRAIL gene 1595C/T polymorphisms contribute to the susceptibility and severity of intervertebral disc degeneration: a data synthesis. 29284457 2017
Entrez Id: 2896
Gene Symbol: GRN
GRN 		0.030 Biomarker disease BEFREE Progranulin derived engineered protein Atsttrin suppresses TNF-α-mediated inflammation in intervertebral disc degenerative disease. 29312639 2017
Entrez Id: 51548
Gene Symbol: SIRT6
SIRT6 		0.020 AlteredExpression disease BEFREE Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration. 29352194 2018
Entrez Id: 392255
Gene Symbol: GDF6
GDF6 		0.020 Biomarker disease BEFREE GDF6 injections resulted in partial restoration of disc height and improvement of MRI disc degeneration grades with statistical significance in rabbit structural analyses. 29460012 2018
Entrez Id: 7130
Gene Symbol: TNFAIP6
TNFAIP6 		0.010 Biomarker disease BEFREE TSG-6 secreted by bone marrow mesenchymal stem cells attenuates intervertebral disc degeneration by inhibiting the TLR2/NF-κB signaling pathway. 29483622 2018
Entrez Id: 283131
Gene Symbol: NEAT1
NEAT1 		0.010 AlteredExpression disease BEFREE NEAT1, p53, and p21 were dramatically upregulated in intervertebral disc degeneration. 29534600 2018