| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | disease | BEFREE | To investigate the role of IL-1 in driving age-related disc degeneration, we studied the spine phenotype of global IL-1α/β double knockout (IL-1KO) mice at 12 and 20 months. | 30875127 | 2019 | ||||
|
0.080 | Biomarker | disease | BEFREE | Interleukin-1 α (IL-1α) was thought to be involved in the pathogenesis of disc degeneration by increasing the production of extracellular matrix degradation enzymes and by inhibiting extracellular matrix synthesis. | 29884765 | 2018 | ||||
|
0.080 | AlteredExpression | disease | BEFREE | We found that serglycin expression increased with increasing disc degeneration both in vivo and in vitro, and also increased with exposure in vitro to IL-1ß and TNF-α. | 29319363 | 2018 | ||||
|
0.080 | Biomarker | disease | BEFREE | The mean percent area for IL-1ß (2.41 ± 0.66 versus 0.13 ± 0.13, p = 0.01), VEGF (3.02 ± 1.01 versus 0.34 ± 0.29, p = 0.04), and substance P (4.15 ± 1.01 versus 1.05 ± 0.46, p = 0.01) was also higher in TDR tissues when compared with disc tissues from patients with painful degenerative disc disease. | 27488379 | 2017 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | We performed a meta-analysis to assess association between interleukin 1 (IL-1) polymorphisms and the risk of Intervertebral Disc Degeneration (IDD). | 27253397 | 2016 | ||||
|
0.080 | Biomarker | disease | BEFREE | This in vitro study has shown that the use of ex vivo gene transfer to degenerate disc tissue is a feasible therapy for the inhibition of IL-1-mediated events during disc degeneration. | 16436110 | 2006 | ||||
|
0.080 | GeneticVariation | disease | BEFREE | IL-1 gene cluster polymorphisms could affect the risk of disc degeneration. | 15308963 | 2004 | ||||
|
0.080 | Biomarker | disease | BEFREE | To study the role of the interleukin-1 beta gene (IL1B) and the IL-1 receptor antagonist gene (IL1RN) in relation to the occurrence of radiographic osteoarthritis (ROA) in the hip, knee, and hand and disc degeneration of the spine. | 15077300 | 2004 |