Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1351
Gene Symbol: COX8A
COX8A 		0.010 AlteredExpression disease BEFREE HELLP syndrome was significantly related to the simultaneous presence of factor VIII and X mutations. 20868443 2010
Entrez Id: 324
Gene Symbol: APC
APC 		0.010 GeneticVariation disease BEFREE HELLP syndrome is characterized by both activation of the APC and frequent germline mutations in APC genes. 29563339 2018
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR 		0.020 GeneticVariation disease BEFREE Methylenetetrahydrofolate reductase polymorphisms in preeclampsia and the HELLP syndrome. 11118403 2000
Entrez Id: 2153
Gene Symbol: F5
F5 		0.040 GeneticVariation disease BEFREE Factor V Leiden and factor II G20210A in preeclampsia and HELLP syndrome. 12519104 2002
Entrez Id: 4153
Gene Symbol: MBL2
MBL2 		0.010 Biomarker disease BEFREE MBL-54 heterozygosity was more frequent in controls (27.2%) than in pre-eclamptic women (4.5%, P = 0.025) and those with HELLP syndrome (11.7%, P = 0.05) who delivered an IUGR neonate. 17314117 2007
Entrez Id: 50639
Gene Symbol: MBL3P
MBL3P 		0.010 Biomarker disease BEFREE MBL-54 heterozygosity was more frequent in controls (27.2%) than in pre-eclamptic women (4.5%, P = 0.025) and those with HELLP syndrome (11.7%, P = 0.05) who delivered an IUGR neonate. 17314117 2007
Entrez Id: 7043
Gene Symbol: TGFB3
TGFB3 		0.010 Biomarker disease LHGDN TGF-beta3 may play a key role as regulator of a variety of cellular events occurring during HELLP syndrome, high local expression of this growth factor may be responsible for remodeling of the placental structure, which results in the dysfunction of maternal-fetal circulation. 17671384 2008
Entrez Id: 4179
Gene Symbol: CD46
CD46 		0.330 GeneticVariation disease ORPHANET Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome. 17914026 2008
Entrez Id: 4179
Gene Symbol: CD46
CD46 		0.330 GeneticVariation disease LHGDN Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome. 17914026 2008
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA 		0.020 GeneticVariation disease BEFREE VEGF polymorphisms were studied in preeclampsia, but not in HELLP syndrome. 18167313 2008
Entrez Id: 51327
Gene Symbol: AHSP
AHSP 		0.010 AlteredExpression disease BEFREE Alpha-hemoglobin-stabilizing protein (AHSP) in hemolysis, elevated liver enzyme, and low platelet (HELLP) syndrome, intrauterine growth restriction (IUGR) and fetal death. 18347943 2008
Entrez Id: 5270
Gene Symbol: SERPINE2
SERPINE2 		0.010 Biomarker disease BEFREE SERPINE2 might be tested clinically in patients for early diagnosis of HELLP syndrome. 18421023 2008
Entrez Id: 3075
Gene Symbol: CFH
CFH 		0.320 Biomarker disease LHGDN Factor H, membrane cofactor protein, and factor I mutations in patients with hemolysis, elevated liver enzymes, and low platelet count syndrome. 18658028 2008
Entrez Id: 3075
Gene Symbol: CFH
CFH 		0.320 GeneticVariation disease ORPHANET Factor H, membrane cofactor protein, and factor I mutations in patients with hemolysis, elevated liver enzymes, and low platelet count syndrome. 18658028 2008
Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2 		0.010 AlteredExpression disease BEFREE ABCG2 expression is reduced in pregnancies where preeclampsia is further complicated by HELLP syndrome. 25446997 2015
Entrez Id: 29124
Gene Symbol: LGALS13
LGALS13 		0.020 Biomarker disease BEFREE PP13 is a marker of severe PE and HELLP syndrome. 28704180 2017
Entrez Id: 355
Gene Symbol: FAS
FAS 		0.220 GeneticVariation disease BEFREE FAS A-670G and Fas ligand IVS2nt A 124G polymorphisms are significantly increased in women with pre-eclampsia and may contribute to HELLP syndrome: a case-controlled study. 30066360 2018
Entrez Id: 5053
Gene Symbol: PAH
PAH 		0.010 GeneticVariation disease BEFREE A locus for the HELLP syndrome is present on chromosome 12q23 near PAH. 23093777 2012
Entrez Id: 355
Gene Symbol: FAS
FAS 		0.220 GeneticVariation disease BEFREE A single A>G nucleotide substitution at position -670 in the maternal but not neonatal TNFRSF6 gene coding for Fas is associated with a higher risk for HELLP syndrome. 16507928 2006
Entrez Id: 2944
Gene Symbol: GSTM1
GSTM1 		0.010 GeneticVariation disease BEFREE A total of 221 women with pre-eclampsia, eclampsia and HELLP syndrome and 147 healthy female controls were genotyped for GSTM1 and GSTT1 polymorphisms by polymerase chain reaction (PCR). 15916660 2005
Entrez Id: 1432
Gene Symbol: MAPK14
MAPK14 		0.020 Biomarker disease BEFREE Activation of villous trophoblastic p38 and ERK1/2 signaling pathways in preterm preeclampsia and HELLP syndrome. 25583406 2015
Entrez Id: 26073
Gene Symbol: POLDIP2
POLDIP2 		0.010 Biomarker disease BEFREE Activation of villous trophoblastic p38 and ERK1/2 signaling pathways in preterm preeclampsia and HELLP syndrome. 25583406 2015
Entrez Id: 7965
Gene Symbol: AIMP2
AIMP2 		0.010 Biomarker disease BEFREE Activation of villous trophoblastic p38 and ERK1/2 signaling pathways in preterm preeclampsia and HELLP syndrome. 25583406 2015
Entrez Id: 25897
Gene Symbol: RNF19A
RNF19A 		0.010 Biomarker disease BEFREE Activation of villous trophoblastic p38 and ERK1/2 signaling pathways in preterm preeclampsia and HELLP syndrome. 25583406 2015
Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1 		0.010 Biomarker disease BEFREE Activation of villous trophoblastic p38 and ERK1/2 signaling pathways in preterm preeclampsia and HELLP syndrome. 25583406 2015