Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4179
Gene Symbol: CD46
CD46
0.330 Biomarker disease BEFREE The coding sequences and intron-exon boundaries of the complement factor H (CFH), complement factor I (CFI), Membrane Cofactor Protein (MCP), complement factor B (CFB) and C3 were sequenced in 33 women with a diagnosis of HELLP syndrome. 22594569 2012
Entrez Id: 4179
Gene Symbol: CD46
CD46
0.330 GeneticVariation disease ORPHANET Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome. 17914026 2008
Entrez Id: 4179
Gene Symbol: CD46
CD46
0.330 Biomarker disease LHGDN Factor H, membrane cofactor protein, and factor I mutations in patients with hemolysis, elevated liver enzymes, and low platelet count syndrome. 18658028 2008
Entrez Id: 4179
Gene Symbol: CD46
CD46
0.330 GeneticVariation disease LHGDN Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome. 17914026 2008
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.320 GeneticVariation disease ORPHANET The coding sequences and intron-exon boundaries of the complement factor H (CFH), complement factor I (CFI), Membrane Cofactor Protein (MCP), complement factor B (CFB) and C3 were sequenced in 33 women with a diagnosis of HELLP syndrome. 22594569 2012
Entrez Id: 3426
Gene Symbol: CFI
CFI
0.320 Biomarker disease BEFREE The coding sequences and intron-exon boundaries of the complement factor H (CFH), complement factor I (CFI), Membrane Cofactor Protein (MCP), complement factor B (CFB) and C3 were sequenced in 33 women with a diagnosis of HELLP syndrome. 22594569 2012
Entrez Id: 3426
Gene Symbol: CFI
CFI
0.320 GeneticVariation disease ORPHANET The coding sequences and intron-exon boundaries of the complement factor H (CFH), complement factor I (CFI), Membrane Cofactor Protein (MCP), complement factor B (CFB) and C3 were sequenced in 33 women with a diagnosis of HELLP syndrome. 22594569 2012
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.320 GeneticVariation disease BEFREE The coding sequences and intron-exon boundaries of the complement factor H (CFH), complement factor I (CFI), Membrane Cofactor Protein (MCP), complement factor B (CFB) and C3 were sequenced in 33 women with a diagnosis of HELLP syndrome. 22594569 2012
Entrez Id: 3426
Gene Symbol: CFI
CFI
0.320 GeneticVariation disease ORPHANET Factor H, membrane cofactor protein, and factor I mutations in patients with hemolysis, elevated liver enzymes, and low platelet count syndrome. 18658028 2008
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.320 Biomarker disease LHGDN Factor H, membrane cofactor protein, and factor I mutations in patients with hemolysis, elevated liver enzymes, and low platelet count syndrome. 18658028 2008
Entrez Id: 3426
Gene Symbol: CFI
CFI
0.320 Biomarker disease LHGDN Factor H, membrane cofactor protein, and factor I mutations in patients with hemolysis, elevated liver enzymes, and low platelet count syndrome. 18658028 2008
Entrez Id: 3075
Gene Symbol: CFH
CFH
0.320 GeneticVariation disease ORPHANET Factor H, membrane cofactor protein, and factor I mutations in patients with hemolysis, elevated liver enzymes, and low platelet count syndrome. 18658028 2008
Entrez Id: 101101692
Gene Symbol: HELLPAR
HELLPAR
0.300 SusceptibilityMutation disease ORPHANET HELLP babies link a novel lincRNA to the trophoblast cell cycle. 23093777 2012
Entrez Id: 355
Gene Symbol: FAS
FAS
0.220 GeneticVariation disease BEFREE FAS A-670G and Fas ligand IVS2nt A 124G polymorphisms are significantly increased in women with pre-eclampsia and may contribute to HELLP syndrome: a case-controlled study. 30066360 2018
Entrez Id: 356
Gene Symbol: FASLG
FASLG
0.220 GeneticVariation disease BEFREE Polymorphisms in the Fas and FasL genes are associated with increased risk of pre-eclampsia and HELLP syndrome. 30066360 2018
Entrez Id: 356
Gene Symbol: FASLG
FASLG
0.220 Biomarker disease RGD Dysregulation of the Fas/FasL system in an experimental animal model of HELLP syndrome. 28501275 2017
Entrez Id: 355
Gene Symbol: FAS
FAS
0.220 Biomarker disease RGD Dysregulation of the Fas/FasL system in an experimental animal model of HELLP syndrome. 28501275 2017
Entrez Id: 355
Gene Symbol: FAS
FAS
0.220 GeneticVariation disease BEFREE A single A>G nucleotide substitution at position -670 in the maternal but not neonatal TNFRSF6 gene coding for Fas is associated with a higher risk for HELLP syndrome. 16507928 2006
Entrez Id: 356
Gene Symbol: FASLG
FASLG
0.220 Biomarker disease LHGDN Taken together, these data suggest that CD95L derived from the placenta acts systemically and is a primary cause of liver damage in HELLP syndrome. 14988839 2004
Entrez Id: 5228
Gene Symbol: PGF
PGF
0.040 Biomarker disease BEFREE Serum levels of sFlt-1 and the sFlt-1/PlGF ratio, but not PlGF, in a woman with AFLP were markedly higher than those in women with HELLP syndrome. 30141235 2019
Entrez Id: 5228
Gene Symbol: PGF
PGF
0.040 AlteredExpression disease BEFREE In the second group, sFlt-1 and PlGF levels of women with PE or HELLP syndrome were measured before and after delivery. 28600845 2018
Entrez Id: 5228
Gene Symbol: PGF
PGF
0.040 Biomarker disease BEFREE We measured serum levels of total and fetal circulating cell-free DNA (cfDNA), soluble endoglin, soluble form of vascular endothelial growth factor receptor, and placental growth factor in a healthy control group of pregnant women (n = 26), patients with mild (n = 37) and severe PE (n = 25), and patients with HELLP syndrome (n = 16). 28338787 2017
Entrez Id: 5228
Gene Symbol: PGF
PGF
0.040 Biomarker disease BEFREE To assess whether the high soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) ratio is associated with adverse outcomes (e.g., HELLP syndrome [hemolysis, elevated liver enzymes, and low platelets], severe hypertension uncontrolled by medication, non-reassuring fetal status, placental abruption, pulmonary edema, growth arrest, maternal death, or fetal death) and a shorter duration to delivery in early-onset fetal growth restriction (FGR). 28737473 2017
Entrez Id: 2153
Gene Symbol: F5
F5
0.040 GeneticVariation disease BEFREE As hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome is one of the most severe forms of pre-eclampsia we aimed to assess the prevalence of the factor V Leiden, the prothrombin 20210G >A mutation and the methylenetetrahydrofolate reductase (MTHFR) 677C >T polymorphism in women with HELLP syndrome and in their fetuses from the same index pregnancy. 18568463 2008
Entrez Id: 2153
Gene Symbol: F5
F5
0.040 GeneticVariation disease BEFREE Schlembach and co-workers in this issue of Clinical Science have studied the association of maternal and/or fetal factor V Leiden (FVL) and prothrombin G20210A gene mutation with HELLP syndrome and intrauterine growth restriction (IUGR) to confirm whether these genetic mutations are important risk factors for the pathogenesis of the HELLP syndrome, leading to an inadequate maternal-fetal circulation. 12780341 2003