Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 GeneticVariation disease BEFREE A recently published genome wide association study of abdominal aortic aneurysms (AAA), based on pooled case control data of European ancestry, identified four new loci for AAA: SMYD2 (top single nucleotide polymorphism [SNP] rs1795061), LINC00540 (rs9316871), PCIF1/MMP9/ZNF335 (rs3827066), and ERG (rs2836411). 31680049 2020
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE Herein, we show that blockade of IL-12p40 in the early phase of aneurysm development suppresses macrophage expansion, inflammatory cytokine and MMP-9 production and mitigates AAA development. 31320700 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 GeneticVariation disease BEFREE We also assessed the potential association between 2 functional single nucleotide polymorphisms in the genes MMP9 (-1561C/T; rs3918242) and MMP13 (-77A/G; rs2252070), and the presence of large AAAs. 29739236 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE In conclusion, blood concentrations of MMP-9 and IL-6 measured in middle age predicted the risk of AAA during 24 years of follow-up. 29945457 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE Gambogic acid treatment markedly decreased the levels of proinflammatory cytokines and oxidative stress factors, and transforming growth factor‑β (TGF‑β) and matrix metalloproteinase (MMP)‑2 and MMP‑9 protein expression in AAA mice. 30535428 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE In the present study, the hypothesis that thin ILT is correlated with an increase in oxidative stress-related enzymes and matrix metalloproteinase-9 (MMP-9) expression within the human AAA wall was investigated. 30351992 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE These observations indicated that Imatinib prevents aneurysm progression by inhibiting STAT3-mediated MMP9 expression and activation, suggesting a new application of Imatinib on AAA clinical therapy. 31325435 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE Sunitinib therapy substantially mitigated both AAA formation and further progression of established AAAs, attenuated aneurysmal aortic MMP2 (matrix metalloproteinase) and MMP9 protein expression, inhibited inflammatory monocyte and neutrophil chemotaxis to VEGF-A, and reduced MMP2, MMP9, and VEGF-A mRNA expression in macrophages and smooth muscle cells in vitro. 31294623 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE B-cell-deficient muMT mice showed suppression of AAA development that was associated with reduced activation of Syk and less expression of matrix metalloproteinase-9. 29545260 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 GeneticVariation disease BEFREE MMP9 rs2234681 microsatellite was the only genetic determinant of TE/A in AAA patients (P = .003), followed by hypercholesterolemia and antiplatelet use. 29291905 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE Transfection of the Egr-1 specific synthetic DNA enzyme EDRz significantly reduced AAA following elastase infusion in rats, at least in part due to the decreased expression of downstream MMP-2 and MMP-9. 29977360 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE MMP-9 in AAA group at T14 (p<0.05 compared with T7 and p<0.005 compared with T0) and calprotectin in AAA group at T14 (p<0.001 compared with T7 and T0) continued to significantly increase at all times. 28155626 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE Moreover, MMP9 levels were significantly higher in TAA group than those in AAA group in the total comparison, and this discrepancy was also found in the non-diabetes, non-hyperlipidemia and aortic diameter ≥ 5.5 cm subgroup analysis. 30373522 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE Embelin inhibited tumor necrosis factor‑α, interleukin (IL)‑1β, IL‑6, IL‑18 and malondialdehyde (MDA) level activities, increased superoxide dismutase, glutathione (GSH) and GSH peroxidase level activities and inhibited MDA level activities in AAA mice Embelin suppressed the secretion of matrix metalloproteinase‑9 protein expression, monocyte chemoattractant protein‑2 activity and epithelial neutrophil‑activating peptide expression levels in AAA mice. 29956759 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE In in vivo experiments, 800 mg/kg GSP could significantly reduce the incidence of AAA, the dilatation of aorta and elastin degradation in media, and dramatically decrease macrophage infiltration and activation and expression of matrix metalloproteinase (MMP) -2 and MMP-9 in the aorta, compared to the AAA model group. 28839206 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE MMP-9 deficiency augmented AngII-induced AAA. 28420827 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE Higher MMP-9 expression was also found in SMCs and macrophages of both AAA and AOD specimens, while higher TIMP-1/TIMP-2 were predominantly observed in the lymphocytes and macrophages of the aneurysm. 29687775 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE RELMβ gene deficiency significantly decreased AAA incidence and severity, which was associated with reduced macrophage accumulation and decreased expression of proinflammatory cytokines (monocyte chemoattractant protein 1 and interleukin 6), matrix metalloproteinase 2 (MMP-2) and MMP-9 in the aortic wall. 29262630 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE We further demonstrated an association between osteogenesis and inflammation; indeed, ha-MSCs cultured with either cytokines (TNF-α, IL-1β) or AAA-PBMCs showed increased expression of MMP-9 and osteogenic markers, to the detriment of the adipogenic regulator PPAR-γ. 28446225 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE Endothelial MMP-9 drives the inflammatory response in abdominal aortic aneurysm (AAA). 29312500 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE Our results suggest that MURC/Cavin-4 in VSMCs modulates AAA progression at the early stage via the activation of JNK and MMP-9. 28433630 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 GeneticVariation disease BEFREE Several studies of gene polymorphisms support MMP-9 for TAA and MMP-3 for AAA as potentially important factors. 28413030 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE We hypothesized that LRP1 downregulation may be mediated by microRNA (miR) and that LRP1 may function as a scavenger of matrix metalloproteinase-9 (MMP-9), a well-known protease for degradation of extracellular matrix proteins at the aortic wall for AAA pathogenesis. 26781079 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 Biomarker disease BEFREE In addition, the protein expressions of several key components involved in AAA pathogenic features are as follows: matrix metalloproteinase (MMP)-2, MMP-9, tissue inhibitor of matrix metalloproteinase (TIMP)-1 and TIMP-2 for elastin degradation; collagen type 1 alpha 1 for compensatory collagen synthesis; monocyte chemoattractant protein-1 for inflammation, were also evaluated. 28288890 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.600 AlteredExpression disease BEFREE In vitro study showed that treating VSMCs with TNF-α together with DOX remarkably inhibited the expressions and activities of MMPs (MMP-2 and MMP-9), significantly suppressed the activation of protein kinase B (AKT) signaling pathway and mitogen-activated protein kinases (MAPKs) signal proteins, including extracellular signal-regulated kinase (ERK), c-Jun amino-terminal kinases (JNK) and p38, and downregulated mRNA levels of interleukin-6 (IL-6) and monocyte chemotactic protein 1 (MCP-1), and significantly upregulated mRNA levels of transforming growth factor beta (TGF-β), heme oxygenase 1 (HO-1) and superoxide dismutase 1 (SOD-1), indicating that DOX inhibits activities of MMPs through reducing oxidative stress, suppressing MAPKs and AKT signaling pathways and ameliorating inflammation in VSMCs, and therefore, exerts preventive as well as therapeutic effects on AAA. 28545777 2017