Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE The development of antibodies to thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) is the major diagnostic hallmark and early indicator of autoimmune thyroid disease. 31794020 2020
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 GeneticVariation disease BEFREE Association between thyroglobulin polymorphisms and autoimmune thyroid disease: a systematic review and meta-analysis of case-control studies. 30139952 2019
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE In patients with PA, a screening for autoimmune thyroid disease is justified, which should first involve the determination of TPOAb (further TgAb) in the blood. 30648728 2019
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE Autoantobodies (AAbs) to thyroid peroxidase (anti-TPO) and thyroglobulin (anti-Tg) as well as AAbs to transglutaminase 2 (anti-TG2) and antibodies to gliadins (anti-gliadins) are serological markers of autoimmune thyroid disease and celiac disease, respectively, and players in pathogenesis of these autoimmune diseases. 29422338 2018
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 GeneticVariation disease BEFREE Association of the polymorphisms in the gene encoding thyroglobulin with the development and prognosis of autoimmune thyroid disease. 28675712 2017
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 GeneticVariation disease BEFREE Correlation between thyroglobulin gene polymorphisms and autoimmune thyroid disease. 26099577 2015
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 GeneticVariation disease BEFREE Multiple SNPs in intron 41 of thyroglobulin gene are associated with autoimmune thyroid disease in the Japanese population. 22662162 2012
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE Our approach of using appropriate human and murine MHC class II transgenic mice, combined with the synthesis and testing of potential pathogenic Tg peptides predicted from computational models of MHC-binding motifs, should continue to provide insights into human autoimmune thyroid disease. 21683551 2011
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE Indeed, traditional models of autoimmune thyroid disease, experimental autoimmune thyroiditis (EAT), are generated by immunizing mice with thyroglobulin protein in conjunction with an adjuvant, or by high repeated doses of Tg alone, without adjuvant. 21559421 2011
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE The thyroglobulin gene is an identified thyroid-specific gene associated to autoimmune thyroid disease and, principally, with autoimmune thyroiditis. 20960158 2010
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 GeneticVariation disease BEFREE Association of the thyroglobulin gene polymorphism with autoimmune thyroid disease in Chinese population. 19034705 2008
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE The thyroglobulin gene as the first thyroid-specific susceptibility gene for autoimmune thyroid disease. 15242677 2004
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 GeneticVariation disease BEFREE The thyroglobulin gene: the third locus for autoimmune thyroid disease or a false dawn? 15242676 2004
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 GeneticVariation disease BEFREE Common allelic variants of exons 10, 12, and 33 of the thyroglobulin gene are not associated with autoimmune thyroid disease in the United Kingdom. 15579800 2004
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 GeneticVariation disease BEFREE Association of a rare thyroglobulin gene microsatellite variant with autoimmune thyroid disease. 14557492 2003
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE In addition to its biochemical importance, Tg has clinical interest in familial goiter and autoimmune thyroid disease. 10403182 1999
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE To explore the possibility of a genetic basis for variability in serum Tg levels, an analysis was made of serum Tg levels in 44 pairs of identical twins and 66 nuclear families who were euthyroid and thyroid autoantibody negative (thereby eliminating subclinical autoimmune thyroid disease and Tg autoantibody interference with the Tg assay). 7889607 1994
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE Autosomal dominant inheritance of autoantibodies to thyroid peroxidase and thyroglobulin--studies in families not selected for autoimmune thyroid disease. 2022716 1991
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE Further studies using a comprehensive panel of gene probes to analyze DNA from families with autoimmune thyroid disease should permit the localization of the gene cluster responsible for regulating the ability to produce autoantibodies to TPO and Tg in man. 2307728 1990
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE Families of each racial group that had a diabetic child (proband) with thyroid autoantibodies (seropositive) or without thyroid autoantibodies (seronegative) were assessed for TgA and TMA as well as autoimmune thyroid disease. 1983329 1990