Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE In patients with PA, a screening for autoimmune thyroid disease is justified, which should first involve the determination of TPOAb (further TgAb) in the blood. 30648728 2019
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE Autoantobodies (AAbs) to thyroid peroxidase (anti-TPO) and thyroglobulin (anti-Tg) as well as AAbs to transglutaminase 2 (anti-TG2) and antibodies to gliadins (anti-gliadins) are serological markers of autoimmune thyroid disease and celiac disease, respectively, and players in pathogenesis of these autoimmune diseases. 29422338 2018
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE ACA = anti-cardiolipin antibodies; ANF = anti-nuclear factor; anti-CCP = anti-cyclic citrullinated peptide; anti-dsDNA = anti-double-stranded DNA; anti-RNP = anti-ribonucleoprotein; anti-Scl70 = anti-topoisomerase I antibodies; anti-SM = anti-Smith antigen antibodies; anti-SS-A/Ro = anti-Sjögren syndrome-related antigen A (Ro); anti-SS-B/La = anti-Sjögren syndrome-related antigen B (La); anti-Tg = anti-thyroglobulin; anti-TPO = anti-thyroid peroxidase; ATD = autoimmune thyroid disease; ENA = extractable nuclear antigen; fT4 = free thyroxine; OR = odds ratio; RF = rheumatoid factor; SLE = systemic lupus erythematosus; SLEDAI = SLE Disease Activity Index; TD = thyroid dysfunction; TSH = thyroid-stimulating hormone; TT3 = total triiodothyronine. 28816533 2017
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 AlteredExpression disease BEFREE The polymorphisms in the thyroid peroxidase gene were associated with the development of autoimmune thyroid disease and the serum levels of anti-thyroid peroxidase antibody. 28845025 2017
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE In addition to TPOAb and TSH, GADA at diagnosis of type 1 diabetes is important for the prediction of autoimmune thyroid disease in children <5 years of age. 28388722 2017
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE These were tested for association with three islet autoantibodies-against autoantibodies to GAD (GADA), IA-2 (IA-2A), and zinc transporter 8 (ZnT8A)-and autoantibodies against thyroid peroxidase (TPOA) in autoimmune thyroid disease, gastric parietal cells (PCA) in autoimmune gastritis, transglutaminase (TGA) in celiac disease, and 21-hydroxylase (21-OHA) in autoimmune hypoadrenalism. 26405073 2015
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE This identification of key residues within the autoreactive epitopes will help in understanding the structural basis for the breakdown of immune tolerance to TPO in thyroid autoimmune disease. 16959834 2006
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE Cellular thyroid peroxidase (TPO), unlike purified TPO and adjuvant, induces antibodies in mice that resemble autoantibodies in human autoimmune thyroid disease. 10323395 1999
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE In the case of some modifications, there were differences in the reactivity of TPO autoantibodies in sera from patients with Addison's disease compared to TPO autoantibodies in autoimmune thyroid disease and/or healthy blood donor sera. 10520899 1999
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE Autoimmune thyroid disease is characterized by the tendency to cluster in families and by IgG class autoantibodies to antigens such as thyroid peroxidase (TPO). 10199790 1999
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE Thyroid peroxidase (TPO) autoantibodies, a hallmark of human autoimmune thyroid disease, may have kappa or lambda light chains. 7926268 1994
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE Expression of recombinant human thyroid peroxidase by the baculovirus system and its use in ELISA screening for diagnosis of autoimmune thyroid disease. 8136455 1993
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE The TSH-receptor (TSH-R) and thyroid peroxidase (TPO) are targets of autoantibody production in the autoimmune thyroid disease, Graves' disease, and are also likely to be the target of T-cell responses. 8397716 1993
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE Immunoreactive TPO was detected in pooled conditioned media from 10 clones using polyclonal TPO autoantibodies in the sera of patients with autoimmune thyroid disease. 8375572 1993
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE These A and B domains contain the binding sites of approximately 80% of IgG-class TPO autoantibodies in the sera of patients with autoimmune thyroid disease. 7686925 1993
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE Use of recombinant epitopes to study the heterogeneous nature of the autoantibodies against thyroid peroxidase in autoimmune thyroid disease. 1370775 1992
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE Autoantibodies directed against the thyroid peroxidase (TPO), the thyroid microsomal antigen, are widely used to diagnose human autoimmune thyroid disease. 1379223 1992
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE The epitope for monoclonal antibody 47 defined in the present study is, therefore, part of or in the vicinity of an epitope for autoimmune thyroid disease-associated TPO antibodies. 1716262 1991
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE The sequential epitopes on the human thyroperoxidase (TPO) recognized by antibodies in the sera of patients with autoimmune thyroid disease were investigated using a recombinant DNA technique. 1716261 1991
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE Autosomal dominant inheritance of autoantibodies to thyroid peroxidase and thyroglobulin--studies in families not selected for autoimmune thyroid disease. 2022716 1991
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE To define the epitope(s) on human thyroid peroxidase (TPO) recognized by antibodies in the sera of patients with autoimmune thyroid disease, we constructed and screened a human TPO cDNA sublibrary containing 3.8 million random fragments of human TPO cDNA, each 200-500 basepairs in length. 1695226 1990
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE Further studies using a comprehensive panel of gene probes to analyze DNA from families with autoimmune thyroid disease should permit the localization of the gene cluster responsible for regulating the ability to produce autoantibodies to TPO and Tg in man. 2307728 1990
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE That investigation led to the isolation of a clone (C2) which encodes an 85-amino acid segment of TPO and harbors a major epitope recognized by serum from several patients with autoimmune thyroid disease that contained anti-M autoantibodies (MAb). 2470771 1989
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE Furthermore, the expressed thyroid peroxidase was immunoreactive to sera of patients with autoimmune thyroid disease in which autoantibodies to thyroid peroxidase appeared. 2590201 1989