Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE The development of antibodies to thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) is the major diagnostic hallmark and early indicator of autoimmune thyroid disease. 31794020 2020
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE In patients with PA, a screening for autoimmune thyroid disease is justified, which should first involve the determination of TPOAb (further TgAb) in the blood. 30648728 2019
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 GeneticVariation disease BEFREE Association between thyroglobulin polymorphisms and autoimmune thyroid disease: a systematic review and meta-analysis of case-control studies. 30139952 2019
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE In patients with PA, a screening for autoimmune thyroid disease is justified, which should first involve the determination of TPOAb (further TgAb) in the blood. 30648728 2019
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE Autoantobodies (AAbs) to thyroid peroxidase (anti-TPO) and thyroglobulin (anti-Tg) as well as AAbs to transglutaminase 2 (anti-TG2) and antibodies to gliadins (anti-gliadins) are serological markers of autoimmune thyroid disease and celiac disease, respectively, and players in pathogenesis of these autoimmune diseases. 29422338 2018
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE Autoantobodies (AAbs) to thyroid peroxidase (anti-TPO) and thyroglobulin (anti-Tg) as well as AAbs to transglutaminase 2 (anti-TG2) and antibodies to gliadins (anti-gliadins) are serological markers of autoimmune thyroid disease and celiac disease, respectively, and players in pathogenesis of these autoimmune diseases. 29422338 2018
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 AlteredExpression disease BEFREE The expression of thyroid-stimulating hormone receptor in OLP lesions suggests that mechanisms related to autoimmune thyroid disease are involved in the aetiology of OLP. 29500871 2018
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 Biomarker disease BEFREE TSH receptor antibodies (TRAbs) are characteristic indicators for the common autoimmune thyroid disease Graves disease (GD). 29265783 2018
Entrez Id: 1493
Gene Symbol: CTLA4
CTLA4
0.100 GeneticVariation disease BEFREE Interaction of HLA-DRB1* alleles and CTLA4 (+49 AG) gene polymorphism in Autoimmune Thyroid Disease. 29174716 2018
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE ACA = anti-cardiolipin antibodies; ANF = anti-nuclear factor; anti-CCP = anti-cyclic citrullinated peptide; anti-dsDNA = anti-double-stranded DNA; anti-RNP = anti-ribonucleoprotein; anti-Scl70 = anti-topoisomerase I antibodies; anti-SM = anti-Smith antigen antibodies; anti-SS-A/Ro = anti-Sjögren syndrome-related antigen A (Ro); anti-SS-B/La = anti-Sjögren syndrome-related antigen B (La); anti-Tg = anti-thyroglobulin; anti-TPO = anti-thyroid peroxidase; ATD = autoimmune thyroid disease; ENA = extractable nuclear antigen; fT4 = free thyroxine; OR = odds ratio; RF = rheumatoid factor; SLE = systemic lupus erythematosus; SLEDAI = SLE Disease Activity Index; TD = thyroid dysfunction; TSH = thyroid-stimulating hormone; TT3 = total triiodothyronine. 28816533 2017
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 AlteredExpression disease BEFREE The polymorphisms in the thyroid peroxidase gene were associated with the development of autoimmune thyroid disease and the serum levels of anti-thyroid peroxidase antibody. 28845025 2017
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 Biomarker disease BEFREE Prevalence and clinical relevance of thyroid stimulating hormone receptor-blocking antibodies in autoimmune thyroid disease. 28439882 2017
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 Biomarker disease BEFREE TSH receptor antibody testing should be considered in pregnant women with any history of autoimmune thyroid disease and symptoms of fetal hyperthyroidism. 27813690 2017
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 GeneticVariation disease BEFREE Association of the polymorphisms in the gene encoding thyroglobulin with the development and prognosis of autoimmune thyroid disease. 28675712 2017
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 Biomarker disease BEFREE Genetics of Thyroid-Stimulating Hormone Receptor-Relevance for Autoimmune Thyroid Disease. 28421036 2017
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE In addition to TPOAb and TSH, GADA at diagnosis of type 1 diabetes is important for the prediction of autoimmune thyroid disease in children <5 years of age. 28388722 2017
Entrez Id: 1493
Gene Symbol: CTLA4
CTLA4
0.100 GeneticVariation disease BEFREE Association of Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) Gene Polymorphisms with Autoimmune Thyroid Disease in Children and Adults: Case-Control Study. 27111218 2016
Entrez Id: 7173
Gene Symbol: TPO
TPO
0.100 Biomarker disease BEFREE These were tested for association with three islet autoantibodies-against autoantibodies to GAD (GADA), IA-2 (IA-2A), and zinc transporter 8 (ZnT8A)-and autoantibodies against thyroid peroxidase (TPOA) in autoimmune thyroid disease, gastric parietal cells (PCA) in autoimmune gastritis, transglutaminase (TGA) in celiac disease, and 21-hydroxylase (21-OHA) in autoimmune hypoadrenalism. 26405073 2015
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 GeneticVariation disease BEFREE Correlation between thyroglobulin gene polymorphisms and autoimmune thyroid disease. 26099577 2015
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 Biomarker disease BEFREE These results indicated that immunization with an autologous TSHR antigen, TSHR739, induced Graves'-like disease in mice, and that TSHR739 is a candidate autoantigen in autoimmune thyroid disease. 23538203 2013
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 Biomarker disease BEFREE The measurement of autoantibodies to thyroid-stimulating hormone receptor (TSHR) is important for the diagnosis of autoimmune thyroid disease such as Graves' disease (GD). 23852019 2013
Entrez Id: 7253
Gene Symbol: TSHR
TSHR
0.100 GeneticVariation disease BEFREE Association between thyroid stimulating hormone receptor gene intron polymorphisms and autoimmune thyroid disease in a Chinese Han population. 22673349 2012
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 GeneticVariation disease BEFREE Multiple SNPs in intron 41 of thyroglobulin gene are associated with autoimmune thyroid disease in the Japanese population. 22662162 2012
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE Our approach of using appropriate human and murine MHC class II transgenic mice, combined with the synthesis and testing of potential pathogenic Tg peptides predicted from computational models of MHC-binding motifs, should continue to provide insights into human autoimmune thyroid disease. 21683551 2011
Entrez Id: 7038
Gene Symbol: TG
TG
0.100 Biomarker disease BEFREE Indeed, traditional models of autoimmune thyroid disease, experimental autoimmune thyroiditis (EAT), are generated by immunizing mice with thyroglobulin protein in conjunction with an adjuvant, or by high repeated doses of Tg alone, without adjuvant. 21559421 2011