| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | Biomarker | phenotype | BEFREE | Phoneutria toxin PnTx3-5 inhibits TRPV1 channel with antinociceptive action in an orofacial pain model. | 31647972 | 2020 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | TRPV1 and TRPV1-Expressing Nociceptors Mediate Orofacial Pain Behaviors in a Mouse Model of Orthodontic Tooth Movement. | 31620023 | 2019 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | Purification and biophysical characterization of a mannose/N-acetyl-d-glucosamine-specific lectin from Machaerium acutifolium and its effect on inhibition of orofacial pain via TRPV1 receptor. | 30772259 | 2019 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | TRPV1 interactions were evaluated using calcium imaging and a rat model of orofacial pain. | 30825343 | 2019 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | Studies have shown that the high expression of transient receptor potential vanilloid 1 (TRPV1) in trigeminal ganglions plays a vital role in the transmission and modulation of orofacial pain. | 30853711 | 2019 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | KR has pharmacological potential for the treatment of acute orofacial pain and this effect is modulated by the opioid and nitrergic systems as well as TRPV1, TRPA1 and ASIC channels. | 30257314 | 2018 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | These results suggest that alkamide affinin, longipinamide A, longipenamide A and longipenamide B isolated from Heliopsis longipes as well as the synthesized analogue compounds N-isobutyl-feruloylamide and N-isobutyl-dihydroferuloylamide produce their effects by activating TRPV1 receptor and they may have potential for the development of new analgesic drugs for the treatment of orofacial pain. | 28374409 | 2017 | ||||
|
0.080 | Biomarker | phenotype | BEFREE | Noteworthy, by testing ADM_12, we shed light on the unprecedented involvement of TRPA1 and TRPV1 channels in orofacial pain. | 25546551 | 2015 |