Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
0.100 AlteredExpression phenotype BEFREE The phosphatidylinositol-3 kinase (PI3K) pathway is activated in multiple myeloma (MM) and Waldenstrom Macroglobulenima (WM), and plays a crucial role in tumor progression and drug resistance. 25060991 2014
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker phenotype BEFREE In this review, we will describe the role of systemic, tumor-derived, and stroma-derived OPN, highlighting its pivotal role at the crossroads of inflammation and tumor progression. 28769537 2017
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.100 Biomarker phenotype BEFREE Vascular endothelial growth factor (VEGF) plays a pivotal role in tumor progression via angiogenesis. 11589304 2001
Entrez Id: 7430
Gene Symbol: EZR
EZR
0.100 AlteredExpression phenotype BEFREE There is increasing evidence that Ezrin is overexpressed in vast majority of malignant tumors and regulates tumor progression. 23098471 2012
Entrez Id: 7430
Gene Symbol: EZR
EZR
0.100 GeneticVariation phenotype BEFREE Molecular and cytogenetic findings have indicated correlations between tumor progression and high-risk GISTs with c-kit mutations, the overexpression of genes such as ezrin, and losses at 9p. 15929122 2005
Entrez Id: 406987
Gene Symbol: MIR204
MIR204
0.100 Biomarker phenotype BEFREE The role of microRNA (miRNA) in modulating tumour progression has been demonstrated, and therapies targeting miRNA appear promising. miR-204-5p has been shown to function in numerous types of cancer, but its role in HCC remains unclear. 29435409 2018
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.100 Biomarker phenotype BEFREE Matrix metalloproteinase-2 (MMP-2) is involved in degradation of extra-cellular matrix proteins and tumor progression. 25313763 2015
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.100 GeneticVariation phenotype BEFREE Systemic inflammation, as evidenced by a chronic elevation in 17 of 18 pro- and anti-inflammatory cytokines and chemokines (P < 0.05 O-SED vs. 2-month-old Y-CON), was potently mitigated by lifelong AET (P < 0.05 O-AET vs. O-SED), including master regulators of the cytokine cascade and cancer progression (IL-1β, TNF-α, and IL-6). 30682077 2019
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
0.100 Biomarker phenotype BEFREE Just as Nrf2 protects normal cells, studies have shown that Nrf2 may also protect cancer cells from chemotherapeutic agents and facilitate cancer progression. 24142871 2013
Entrez Id: 6495
Gene Symbol: SIX1
SIX1
0.100 AlteredExpression phenotype BEFREE Overexpression of SIX1 contributes to cancer progression and is associated with adverse outcomes in various cancer types including breast, ovarian, uterine cervical and liver. 24866365 2014
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
0.100 Biomarker phenotype BEFREE OPN is a well-known multifunctional factor involved in various aspects of cancer progression, including endometrial cancer. 26509489 2015
Entrez Id: 10855
Gene Symbol: HPSE
HPSE
0.100 Biomarker phenotype BEFREE Heparanase is closely related to growth factors in the role of promoting tumor progression. 21624769 2011
Entrez Id: 5979
Gene Symbol: RET
RET
0.100 GeneticVariation phenotype BEFREE To explain this finding, we can hypothesize either that other oncogene(s) might be responsible for the majority of microMTC, thus identifying a tumor subset, or that the RET mutation might, or might not, occur later during tumor progression. 22404432 2012
Entrez Id: 9839
Gene Symbol: ZEB2
ZEB2
0.100 AlteredExpression phenotype BEFREE Expression of SIP1 in oral squamous cell carcinomas: implications for E-cadherin expression and tumor progression. 16273209 2005
Entrez Id: 7291
Gene Symbol: TWIST1
TWIST1
0.100 AlteredExpression phenotype BEFREE Hence, TP, when transcriptionally activated by Twist1, promotes HCC VM formation and metastasis through the pentose Warburg effect and contributes to tumor progression. 30674871 2019
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
0.100 Biomarker phenotype BEFREE Matrix metalloproteinase 9 (MMP-9) and interleukin-8 (IL-8) play major roles in tumor progression and invasion of breast cancer cells. 23933110 2013
Entrez Id: 2263
Gene Symbol: FGFR2
FGFR2
0.100 GeneticVariation phenotype BEFREE Periodic mutation profiling of patient's circulating tumor DNA (ctDNA) by next generation sequencing (NGS) revealed a number of genetic alterations including re-occurrence of MET amplification, multiple secondary MET mutations, a dramatic increase of FGFR2 gene relative copy number as well as mutations in other downstream and bypassing elements, which may collectively related to the patient's cancer progression. 28460431 2017
Entrez Id: 29072
Gene Symbol: SETD2
SETD2
0.100 GeneticVariation phenotype BEFREE Recent findings show that over-expression or mutation of Set2 enzymes promotes cancer progression, however, mechanisms of H3K36me are poorly understood. 31439846 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.100 GeneticVariation phenotype BEFREE Logistic regression analysis revealed that the risk factors of a tumorous histotype were the positive expression of p53 (odds ratio [OR] = 18.214) or COX-2 (OR = 42.703), and no reciprocal relationship to neoplastic progression was recognized with p53, p16 and COX-2. 17650224 2007
Entrez Id: 960
Gene Symbol: CD44
CD44
0.100 Biomarker phenotype BEFREE The biology and role of CD44 in cancer progression: therapeutic implications. 29747682 2018
Entrez Id: 50943
Gene Symbol: FOXP3
FOXP3
0.100 Biomarker phenotype BEFREE Our data demonstrate that cancer progression in the <i>N</i>-methyl-<i>N</i>-nitrosourea (MNU) rat model of bladder cancer was characterized by a decline in the CD8/FoxP3 ratio, consistent with decreased adaptive immunity. 28588015 2017
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 Biomarker phenotype BEFREE Bcl-2 is an oncogene which promotes tumour progression by specifically inhibiting programmed cell death. 8783649 1996
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker phenotype BEFREE The epidermal growth factor receptor (EGFR) plays an important role in tumorigenesis and tumor progression of colorectal cancer (CRC). 19117687 2009
Entrez Id: 3159
Gene Symbol: HMGA1
HMGA1
0.100 Biomarker phenotype BEFREE Because HMGA1 drives tumor progression by inducing MatrixMetalloproteinase (MMP) and other genes involved in invasion, we explored the HMGA1-MMP-2 pathway in uterine cancer. 27001612 2016
Entrez Id: 7405
Gene Symbol: UVRAG
UVRAG
0.100 AlteredExpression phenotype BEFREE Since p63 transcriptionally regulated expression of many of the genes in this signalling pathway, it suggests that it has a central role in cancer progression. 26001294 2017