Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE The high frequency of mutations of the p53 tumor-suppressor gene in human cancers, including primary brain tumors, suggests that p53 plays a critical role in carcinogenesis and tumor progression. 7644054 1995
Entrez Id: 595
Gene Symbol: CCND1
CCND1
0.100 GeneticVariation phenotype BEFREE Given these data establishing the potency of cyclin D1-mediated repression, we evaluated the ability of cyclin D1 to inhibit tumor-derived AR alleles and polymorphisms associated with tumor progression and increased prostate cancer risk. 12941814 2003
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE Recent evidence indicates that some mutations in p53 arise as the cancer progresses from a benign tumor to a metastatic tumor and that these mutations in p53 actively contribute to the process of cancer progression. 16236433 2006
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation phenotype BEFREE The observation of TERT promotor and BRAF mutations in sporadic MPNSTs and the absence of TERT promotor and rarity of BRAF mutations in NF1 related tumors may imply an alternative genetic route of tumor progression in both patient groups. 25035100 2015
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.100 GeneticVariation phenotype BEFREE Previous studies indicate that some tumors express alternatively or aberrantly spliced Mdm2 variants that are unable to bind p53, but whether these actively contribute to carcinogenesis or are a byproduct of cancer progression has been unclear. 14522887 2003
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.100 GeneticVariation phenotype BEFREE Aberrant expression or activity of the epidermal growth factor (EGF) receptor family of tyrosine kinases has been associated with tumor progression and an invasive phenotype. 9766568 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE These results suggest that (i) significant differences in the frequency of p53 mutations are present among subtypes of neoplasms derived from the same tissue; (ii) p53 may play a role in tumor progression in B-cell chronic lymphocytic leukemia; (iii) the presence of both p53 loss/inactivation and c-myc oncogene activation may be important in the pathogenesis of Burkitt lymphoma and its leukemic form L3-type B-cell acute lymphoblastic leukemia. 2052620 1991
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE K-ras mutation is critical in the formation of ACF, but p53 alteration could play a causal role in tumor progression. 7835585 1995
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.100 GeneticVariation phenotype BEFREE Correspondingly, in established murine BRAF(V600E)-driven nevi, acute shRNA-mediated depletion of PTEN prompted tumor progression. 22549727 2012
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE These findings suggest that wt p53 protein has a function in maintaining genomic stability after X-ray irradiation through the G1 checkpoint and loss of p53 function(s) may lead to tumor progression in multi-step tumorigenesis. 9111202 1997
Entrez Id: 4233
Gene Symbol: MET
MET
0.100 GeneticVariation phenotype BEFREE Overexpression of the hepatocyte growth factor receptor (Met/HGF receptor), a transmembrane tyrosine kinase encoded by the met proto-oncogene, has been associated with tumor progression in different human carcinomas. 8863670 1996
Entrez Id: 367
Gene Symbol: AR
AR
0.100 GeneticVariation phenotype BEFREE Alterations of AR and/or associated regulatory networks are known to restore receptor activity and support resultant therapy-resistant tumor progression. 20138542 2010
Entrez Id: 7852
Gene Symbol: CXCR4
CXCR4
0.100 GeneticVariation phenotype BEFREE C1013G/CXCR4 acts as a driver mutation of tumor progression and modulator of drug resistance in lymphoplasmacytic lymphoma. 24711662 2014
Entrez Id: 4613
Gene Symbol: MYCN
MYCN
0.100 GeneticVariation phenotype BEFREE Amplification of the MYCN gene strongly correlates with advanced stage, rapid tumor progression and poor prognosis in neuroblastoma (NB). 17028906 2007
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE We conclude that p53 protein overexpression is a common finding in some entities of T- and T/NK-cell lymphomas, whereas a p53 gene mutation is a rare, sporadic, and rather late event associated with tumor progression in some instances. 11230707 2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE Different missense mutations in p53 may confer unique activities and thereby offer insight into the mutagenic events that drive tumor progression. 22713868 2012
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.100 GeneticVariation phenotype BEFREE The transformed phenotype of IOE(CMYC) cells was further enhanced in concert with KRAS(G12V)/BRAF(V600E) expression, as in vitro analyses indicated that IOE(CMYC) cells had undergone morphological and phenotypic changes characteristic of neoplastic progression. 21859834 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE To further examine the idea that neoplastic progression is associated with mutations in the p53 gene, we analyzed matched primary and metastatic tumor samples. 7619219 1995
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE Wip1 over-expression inhibits p53 function and reduces selection for TP53 mutations during cancer progression. 21695702 2011
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE Mutation and deletion of the p53 tumor suppressor gene are arguably the most prevalent among the multiple genetic alterations found in human bladder cancer, but these p53 defects are primarily associated with the advanced diseases, and their roles in bladder tumor initiation and in synergizing with oncogenes in tumor progression have yet to be defined. 14737103 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE Notably, TP53 mutation, which has been used as a marker of tumor progression in many human cancers, was less significant in associating with progression in this study (P = 0.04) than was p16 or pRb alteration (P = 0.001). 9436977 1998
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE Our results yield two implications: that p53 alterations have a crucial and early role in gastric carcinogenesis of intestinal type, likely acting at the transition step between metaplasia and dysplasia; and that the alterations are mainly associated with tumor progression in cancer of diffuse type. 7606196 1995
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE The aim of this study was to investigate the hypothesis that altered patterns of expression of the protein product(s) of the mutated p53 tumor suppressor gene are associated with tumor progression in patients with T1 bladder cancer. 7677935 1993
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE Neoplastic progression in BE is associated with alterations in TP53 (also known as p53) and CDKN2A (also known as p16) and non-random losses of heterozygosity (LOH). 10319873 1999
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
0.100 GeneticVariation phenotype BEFREE The hypoxia inducible factor 1-alpha (HIF1A) gene has been suggested to play a critical role in cancer progression, and the relationship between HIF1A rs11549465 polymorphism and risk of prostate cancer has been investigated in previous studies. 28415653 2018