Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 51146
Gene Symbol: A4GNT
A4GNT
0.010 AlteredExpression phenotype BEFREE Surprisingly, alpha4GnT mRNA was detectable in 80% of five patients with an early stage of gastric cancer when the cancer cells were limited to the gastric mucosa, and the expression levels of alpha4GnT mRNA were increased in association with tumor progression. 12594234 2003
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.040 AlteredExpression phenotype BEFREE Our results suggest that MDR1/P-gp expression may have an important role to play in tumor progression in the cases of soft tissue sarcoma, and p53 may be one of the active regulators of the MDR1 transcript. 15609299 2005
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.040 AlteredExpression phenotype BEFREE In the present study, a strong positive correlation between MDR1 and Anxa2 mRNA expression in invasive breast cancer tissues during cancer progression was observed. 24239898 2014
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.040 Biomarker phenotype BEFREE Expression of bcl-2 in testicular carcinoma: correlation with tumor progression and MDR1/Pgp. 9669816 1998
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.040 AlteredExpression phenotype BEFREE YB-1 is upregulated during prostate cancer tumor progression and increases P-glycoprotein activity. 15042610 2004
Entrez Id: 10257
Gene Symbol: ABCC4
ABCC4
0.010 Biomarker phenotype BEFREE Here, we studied the role of MRP4/ABCC4 in tumor progression in a mouse xenograft model and in leukemic stem cells (LSCs) differentiation. 25301721 2015
Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
0.020 Biomarker phenotype BEFREE Cytoplasmatic accumulation of ABCG2 in poorly differentiated carcinomas might coincide with malfunctioning of PI3K-signaling pathways during tumor progression. 15146167 2004
Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
0.020 Biomarker phenotype BEFREE ABCG2, CD133 and CD117 are pivotal markers of cancer stem cell, which are involved in carcinogenesis and cancer progression. 26951883 2018
Entrez Id: 10006
Gene Symbol: ABI1
ABI1
0.010 Biomarker phenotype BEFREE Because of its role in cell migration, Abi1 has been implicated in tumor progression. 26193797 2015
Entrez Id: 51225
Gene Symbol: ABI3
ABI3
0.010 Biomarker phenotype BEFREE Specifically, in IGHV unmutated CLL, we identified methylation of 7 known or candidate tumor suppressor genes (eg, VHL, ABI3, and IGSF4) as well as 8 unmethylated genes involved in cell proliferation and tumor progression (eg, ADORA3 and PRF1 enhancing the nuclear factor-kappaB and mitogen-activated protein kinase pathways, respectively). 19897574 2010
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.030 Biomarker phenotype BEFREE Mutations in the P53 and RAS family genes are associated with tumor progression of BCR/ABL negative chronic myeloproliferative disorders. 8321046 1993
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.030 Biomarker phenotype BEFREE These data indicate that p53 inactivation and/or Ras activation might play a role in acute transformation of BCR/ABL- CMPD and that the molecular mechanisms of tumor progression may be different in BCR/ABL+ versus BCR/ABL-CMPD. 8152300 1994
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.030 Biomarker phenotype BEFREE The interaction between STAP-2 and BCR-ABL plays a crucial role in conferring a growth advantage and resistance to imatinib, a BCR-ABL inhibitor, as well as tumor progression. 22231445 2013
Entrez Id: 27034
Gene Symbol: ACAD8
ACAD8
0.010 Biomarker phenotype BEFREE We postulate that loss of these tumor suppressor miRNAs predispose to chronic inflammation and neoplastic progression in IBD. 21557394 2012
Entrez Id: 1636
Gene Symbol: ACE
ACE
0.010 Biomarker phenotype BEFREE In this study we investigated the putative pathophysiological mechanism, by which angiotensin converting enzyme (ACE), and angiotensin II receptor (ATR) type 1 and 2 might contribute to cancer progression and lymph node metastasis in gastric cancer. 18059164 2010
Entrez Id: 57007
Gene Symbol: ACKR3
ACKR3
0.040 Biomarker phenotype BEFREE The chemokine CXCL12 (also termed SDF-1, stromal cell-derived factor-1) and its receptors CXCR4 and CXCR7 are known to play a pivotal role in tumor progression including glioblastomas (GBM). 26821357 2016
Entrez Id: 57007
Gene Symbol: ACKR3
ACKR3
0.040 Biomarker phenotype BEFREE The G-protein coupled receptor associated protein β-arrestin-1 is crucial for the regulation of numerous biological processes involved in cancer progression, such as intracellular signaling and cell motility. 21497294 2011
Entrez Id: 57007
Gene Symbol: ACKR3
ACKR3
0.040 Biomarker phenotype BEFREE G-protein-coupled receptor kinase interacting protein 1 (GIT1) is participated in cell movement activation, which is a fundamental process during tissue development and cancer progression. 26462147 2016
Entrez Id: 57007
Gene Symbol: ACKR3
ACKR3
0.040 Biomarker phenotype BEFREE The chemokine CXCL12, and its receptors CXCR4 and CXCR7 have been involved in tumor progression and dissemination. 22916293 2013
Entrez Id: 94
Gene Symbol: ACVRL1
ACVRL1
0.010 Biomarker phenotype BEFREE Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression. 24133138 2014
Entrez Id: 100188830
Gene Symbol: AD12
AD12
0.010 Biomarker phenotype BEFREE Ad12-SV40-transformed human melanocytes and nevus cells are useful tools for studying tumor progression under experimental conditions. 2558080 1990
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
0.020 AlteredExpression phenotype BEFREE A disintegrin and metalloprotease 10 (ADAM10) is upregulated in several cancers and associates with malignant cancer progression. 24935471 2014
Entrez Id: 102
Gene Symbol: ADAM10
ADAM10
0.020 Biomarker phenotype BEFREE The disintegrin metalloprotease ADAM-10 is a multidomain metalloprotease that is potentially significant in tumor progression due to its extracellular matrix-degrading properties. 14734484 2004
Entrez Id: 8038
Gene Symbol: ADAM12
ADAM12
0.060 AlteredExpression phenotype BEFREE Interestingly, we show that ADAM12 endogenously expressed in tumor-associated stroma in the PyMT model does not influence tumor progression, but that ADAM12 expression by tumor cells is necessary for tumor progression in these mice. 21875931 2012
Entrez Id: 8038
Gene Symbol: ADAM12
ADAM12
0.060 Biomarker phenotype BEFREE Here ADAM12, a protease that promotes tumor progression and chondrocyte proliferation in osteoarthritic cartilage, is shown to possess a prodomain/catalytic domain cationic molecular switch, regulated by exogenous heparan sulfate and heparin but also endogenous cell surface proteoglycans and the polyanion, calcium pentosan polysulfate. 18801731 2009