Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 51146
Gene Symbol: A4GNT
A4GNT
0.010 AlteredExpression phenotype BEFREE Surprisingly, alpha4GnT mRNA was detectable in 80% of five patients with an early stage of gastric cancer when the cancer cells were limited to the gastric mucosa, and the expression levels of alpha4GnT mRNA were increased in association with tumor progression. 12594234 2003
Entrez Id: 26574
Gene Symbol: AATF
AATF
0.010 AlteredExpression phenotype BEFREE We identify the transcriptional regulator AATF/CHE-1 as a key molecule to sustain proliferative tissues and tumor progression in parts by inhibiting p53-driven apoptosis in vivo. 29321668 2018
Entrez Id: 24
Gene Symbol: ABCA4
ABCA4
0.010 Biomarker phenotype BEFREE Effect of RMP on tumor progression in nude mouse models was assessed by measurement of volume and weight of tumors. 31333787 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker phenotype BEFREE Taken together, these results suggest that extracellular galectin-1 contributes to cancer progression and doxorubicin resistance in TNBC cells. 28415760 2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression phenotype BEFREE Our results suggest that MDR1/P-gp expression may have an important role to play in tumor progression in the cases of soft tissue sarcoma, and p53 may be one of the active regulators of the MDR1 transcript. 15609299 2005
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression phenotype BEFREE YB-1 is upregulated during prostate cancer tumor progression and increases P-glycoprotein activity. 15042610 2004
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker phenotype BEFREE Expression of bcl-2 in testicular carcinoma: correlation with tumor progression and MDR1/Pgp. 9669816 1998
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression phenotype BEFREE In conclusion, continuous PTX treatment caused the over-expression of P-gp and acquisition of MDR in colon cancer and glioblastoma cell lines, while some mechanisms of MDR and tumor progression such as GSH detoxification system and VEGF secretion were suppressed. 21775090 2011
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression phenotype BEFREE Within this panel, mdr1 mRNA biosynthesis and surface localisation of Pgp were assessed with respect to MDR functionality where the cell lines are representative of different clinical stages of tumour progression, metastatic potential and differentiation. 8098614 1993
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker phenotype BEFREE These results demonstrated that ECM remodeling during tumor progression increased CS chains to facilitate EMT and ABCB1 upregulation, contributing to chemoresistance acquisition. 30016638 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression phenotype BEFREE No correlation was found between MDR1 or N-myc genes expression and tumor progression. 1974410 1990
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression phenotype BEFREE The resistance on HT-29 cell-derived matrices increased through the activation of Akt and the upregulation of ABCB1 and ABCC1 without cell growth promotion, suggesting that ECM remodeling plays important roles in the acquisition of chemoresistance during tumor progression. 27558478 2016
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker phenotype BEFREE circKDM4C suppresses tumor progression and attenuates doxorubicin resistance by regulating miR-548p/PBLD axis in breast cancer. 31406252 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker phenotype BEFREE The present results indicate that the MDR1 gene is not associated in NSCLC with tumor progression and drug resistance. 9066608 1997
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker phenotype BEFREE Additionally, P-glycoprotein (MDR1) and c-Myc, contributing to tumor progression, were suppressed by the nanoparticles, while p53 was improved in drug-resistant cells. 28958938 2017
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression phenotype BEFREE However, there is growing evidence that regulation primarily takes place at the transcriptional level and that the process of tumour progression is related to activation of the MDR1 gene. 8898977 1996
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 PosttranslationalModification phenotype BEFREE The promoter methylation of MDR1 seems to have a significant role in carcinogenesis and tumor progression in the stomach. 19331170 2009
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression phenotype BEFREE We studied the role of caveolin-1 in tumor progression and prognosis in serous ovarian carcinoma and the association between caveolin-1 and MDR1 expression. 11863219 2002
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression phenotype BEFREE Thirdly, we review evidence that P-gp activity is enhanced in the process of epithelial-to-mesenchymal transition (EMT), which is associated with cancer progression, without any increase in expression of P-gp mRNA. 29311472 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 PosttranslationalModification phenotype BEFREE MDR1 gene could be activated via epigenetic mechanisms with demethylation of Line-1 in ESCC, and enhance tumor progression. 26823755 2015
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression phenotype BEFREE In the present study, a strong positive correlation between MDR1 and Anxa2 mRNA expression in invasive breast cancer tissues during cancer progression was observed. 24239898 2014
Entrez Id: 23456
Gene Symbol: ABCB10
ABCB10
0.010 Biomarker phenotype BEFREE Circ-ABCB10 promotes tumor progression and correlates with pejorative prognosis in ccRCC. 31106654 2019
Entrez Id: 5244
Gene Symbol: ABCB4
ABCB4
0.020 Biomarker phenotype BEFREE Hepatitis B virus surface proteins accelerate cholestatic injury and tumor progression in Abcb4-knockout mice. 28881751 2017
Entrez Id: 5244
Gene Symbol: ABCB4
ABCB4
0.020 Biomarker phenotype BEFREE Treatment of Mdr2-/- mice with a CAR inhibitor blocked cancer progression and caused a partial regression of existing tumors. 29734330 2018
Entrez Id: 10058
Gene Symbol: ABCB6
ABCB6
0.020 Biomarker phenotype BEFREE A better understanding of the complex role of ABC proteins in relation to cancer progression may offer novel strategies in cancer therapy. 29401721 2018