Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 GeneticVariation phenotype BEFREE The frequency of apoptosis in colorectal neoplasia appears to increase in the course of tumor progression in association with a decline in bcl-2 expression, but is not influenced by p53 gene mutations. 9143411 1997
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 GeneticVariation phenotype BEFREE These data suggest that, in endometrial carcinomas, Bcl-2 and p53 alterations may play important roles in determining whether tumor progression from early to advanced stages will occur. 9292705 1997
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 AlteredExpression phenotype BEFREE Protein expression of BCL-2 in prostate cancer is highly correlated with cancer progression and androgen-independent phenotype. 9090501 1997
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 GeneticVariation phenotype BEFREE We conclude that, in contrast to its role in gastric neoplasia, bcl-2 alterations are not an important molecular marker in the neoplastic progression of Barrett's mucosa. 8552577 1996
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 AlteredExpression phenotype BEFREE This suggests the possibility that alterations in p53 followed by over-expression of bcl-2 occur early in oral carcinogenesis resulting in defective apoptosis and subsequent tumor progression. 8697436 1996
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 Biomarker phenotype BEFREE The bcl-2 immunostaining pattern could be subdivided into two groups, basal type and diffuse type, with the incidence of the latter being clearly increased, in line with tumor progression. 8635035 1996
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 AlteredExpression phenotype BEFREE Inhibition of apoptosis through bcl-2 protein expression appears to be specifically associated with promotion of intestinal-type gastric adenocarcinoma but does not appear to be active and/or correlated with tumor progression. 7712429 1995
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 GeneticVariation phenotype BEFREE Abnormal bcl-2 immunoreactivity in 1), the earliest precursor dysplastic lesions and its persistence throughout neoplastic progression and 2), contiguous morphologically unaltered nondysplastic epithelium suggests that bcl-2 alterations occur early during the morphological and molecular sequence of events leading to gastrointestinal epithelial neoplasia. 7856728 1995
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 AlteredExpression phenotype BEFREE We conclude from our results that bcl-2 protein is expressed by benign and malignant melanocytic tumors of the skin, but there is loss of bcl-2 protein expression with increasing tumor progression. 7777475 1995
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 GeneticVariation phenotype BEFREE Somatic point mutations in the translocated bcl-2 genes of non-Hodgkin's lymphomas and lymphocytic leukemias: implications for mechanisms of tumor progression. 8220113 1993