Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE Our data showed that (1) the frequency of C609T NQO1 was significantly increased in TNM stage III HCC patients; (2) no significant association was found between p53 expression and C609T polymorphism of NQO1 gene; and (3) a tumor/non-tumor (T/N) ratio > 1.27 of NQO1 expression revealed by real-time qPCR analyses was positively correlated with poorer survival in patients with tumors >5 cm, suggesting that an increase of NQO1 expression may be an indicator of advanced tumor progression. 19688691 2009
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.100 GeneticVariation phenotype BEFREE Mutation of the PTEN gene in advanced cervical cancer correlated with tumor progression and poor outcome after radiotherapy. 11179477 2001
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE To better isolate the potential effects of p53 gene mutations per se on tumor progression, we chose to examine patients with advanced disease in whom surgery was not performed (stages IIIA, IIIB, and IV). 10690534 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE The higher frequency of mutations in cell lines (70%) suggests that mutation of p53 may be associated with tumor progression. 1638540 1992
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.100 GeneticVariation phenotype BEFREE A similar ser120-gly mutation in NME1 has been found in human neuroblastoma, suggesting that mutation in this region may be a general phenomenon related to tumor progression. 7794272 1995
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE The role of combined allelic imbalance and mutations of p53 in tumor progression and survival following surgery for colorectal carcinoma. 16273227 2005
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE The genetic findings of this patient suggest that the increased genetic instability could contribute to tumor progression as well as to treatment resistance, possibly in the background of the clonal deletion of TP53. 15866438 2005
Entrez Id: 2264
Gene Symbol: FGFR4
FGFR4
0.100 GeneticVariation phenotype BEFREE This LOH involved the FGFR4-WT allele as frequently as the cancer progression-associated FGFR4-G388R polymorphic allele. 21037081 2010
Entrez Id: 354
Gene Symbol: KLK3
KLK3
0.100 GeneticVariation phenotype BEFREE We assessed the predictive value of TP53 mutations and prostate-specific antigen (PSA) for tumor progression in prostate cancer (PCa) patients. 20592345 2010
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE Cox-Regression analysis showed a significant and independent influence of TP53 mutation on tumour progression in comparison with tumour grade, stage and history of prior bladder cancer. 18425359 2008
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE Wip1 over-expression inhibits p53 function and reduces selection for TP53 mutations during cancer progression. 21695702 2011
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.100 GeneticVariation phenotype BEFREE Constitutional hMSH2/hMLH1 mutations rarely are reported in other than colon MIN+ tumor types; 2) MIN in non-HNPCC tumors generally is not associated with somatic mutations in the mismatch DNA repair genes most commonly involved in HNPCC; 3) loci of individual chromosomes containing microsatellite markers demonstrating high MIN frequency may be linked to particular tumor types (tumor specific MIN hot spots); 4) the gel banding patterns of MIN observed in noncolon tumors differ significantly from those reported previously in HNPCC; 5) although overall no association between MIN and histopathology is observed in the literature, a statistically higher MIN frequency has been noted in certain tumor subtypes; and 6) MIN in tumors can be associated with early or late stages of tumor progression, and also has been found in nontumor tissues. 9587112 1998
Entrez Id: 596
Gene Symbol: BCL2
BCL2
0.100 GeneticVariation phenotype BEFREE These data suggest that, in endometrial carcinomas, Bcl-2 and p53 alterations may play important roles in determining whether tumor progression from early to advanced stages will occur. 9292705 1997
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.100 GeneticVariation phenotype BEFREE Distinct somatic genetic changes associated with tumor progression in carriers of BRCA1 and BRCA2 germ-line mutations. 9102202 1997
Entrez Id: 1950
Gene Symbol: EGF
EGF
0.100 GeneticVariation phenotype BEFREE Epidermal growth factor receptor (EGFR) and Cortactin are molecular markers that are important in tumour progression and development, and interact within the EGF pathway. 29201160 2017
Entrez Id: 346389
Gene Symbol: MACC1
MACC1
0.100 GeneticVariation phenotype BEFREE The newly identified gene, metastasis‑associated in colon cancer 1 (MACC1), is suggested to be a transcriptional regulator of c‑Met, leading to cancer progression in colorectal cancer. 25738887 2015
Entrez Id: 115482713
Gene Symbol: H3P10
H3P10
0.100 GeneticVariation phenotype BEFREE Moreover, p16 and p15 gene deletion was related to tumor progression and might have a role in bilharzial bladder carcinogenesis. 15590562 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE Expression of vascular endothelial growth factor in human oral squamous cell carcinoma: its association with tumour progression and p53 gene status. 10023341 1998
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
0.100 GeneticVariation phenotype BEFREE Several polymorphisms within the MMP2 promoter region have been reported in cases with oncogenesis and tumor progression, especially in colorectal carcinogenesis. 24998576 2014
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE Altogether, N-ras p21 alterations are registered at earlier stages than p53 alterations in melanoma development and may be of aetiological importance, whereas p53 alterations may be associated with tumour progression in the late stages.(ABSTRACT TRUNCATED AT 250 WORDS) 7620336 1995
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.100 GeneticVariation phenotype BEFREE Due to compromised homologous recombination (HR) repair, BRCA1- and BRCA2-mutated tumours accumulate DNA damage and genomic rearrangements conducive of tumour progression. 31273933 2019
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE Microsatellite instability and p53 mutation associated with tumor progression in dermatofibrosarcoma protuberans. 14991543 2004
Entrez Id: 7157
Gene Symbol: TP53
TP53
0.100 GeneticVariation phenotype BEFREE Notably, TP53 mutation, which has been used as a marker of tumor progression in many human cancers, was less significant in associating with progression in this study (P = 0.04) than was p16 or pRb alteration (P = 0.001). 9436977 1998
Entrez Id: 115482696
Gene Symbol: H3P23
H3P23
0.100 GeneticVariation phenotype BEFREE Our findings suggest that the p27 109GG variant genotype may not play a major role in the etiology of SCCHN but may be associated with an increased risk in at-risk subgroups or subsets of SCCHN, particularly oral cavity cancer and possibly tumor progression. 15217930 2004
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.100 GeneticVariation phenotype BEFREE Recent reports indicate that the alterations in the p16 and pRb pathways can influence tumour progression and poor prognosis in several tumours. 17094467 2006