Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10058
Gene Symbol: ABCB6
ABCB6
0.020 AlteredExpression phenotype BEFREE The current study tested our hypothesis that the expression levels of ABC genes in non-neoplastic (control) tissues also provide important information in relation to the relevant tumor progression. 28819395 2017
Entrez Id: 4363
Gene Symbol: ABCC1
ABCC1
0.030 Biomarker phenotype BEFREE The resistance on HT-29 cell-derived matrices increased through the activation of Akt and the upregulation of ABCB1 and ABCC1 without cell growth promotion, suggesting that ECM remodeling plays important roles in the acquisition of chemoresistance during tumor progression. 27558478 2016
Entrez Id: 4363
Gene Symbol: ABCC1
ABCC1
0.030 AlteredExpression phenotype BEFREE Taken together, these findings suggest MUC1 regulates the expression of MRP1 and provides a direct link between cancer progression and chemoresistance in mammary carcinoma cells. 27221150 2016
Entrez Id: 4363
Gene Symbol: ABCC1
ABCC1
0.030 Biomarker phenotype BEFREE These findings suggest that export of S1P via ABCC1 functions in a malicious feed-forward manner to amplify the S1P axis involved in breast cancer progression and metastasis, which has important implications for prognosis of breast cancer patients and for potential therapeutic targets.<b>Implication:</b> Multidrug resistant transporter ABCC1 and activation of SPHK1 in breast cancer worsen patient's survival by export of S1P to the tumor microenvironment to enhance key processes involved in cancer progression.<i></i>. 29523764 2018
Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
0.010 Biomarker phenotype BEFREE Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer. 31378204 2019
Entrez Id: 10257
Gene Symbol: ABCC4
ABCC4
0.030 Biomarker phenotype BEFREE Here, we studied the role of MRP4/ABCC4 in tumor progression in a mouse xenograft model and in leukemic stem cells (LSCs) differentiation. 25301721 2014
Entrez Id: 10257
Gene Symbol: ABCC4
ABCC4
0.030 AlteredExpression phenotype BEFREE In the context of several types of cancer in which MRP4 is overexpressed, MRP4 inhibition manifests striking effects against cancer progression and drug resistance. 30321196 2018
Entrez Id: 10257
Gene Symbol: ABCC4
ABCC4
0.030 Biomarker phenotype BEFREE These results in together have revealed a previously undefined role of MRP4 in mediating ENaC-dependent CREB/COX-2/PGE<sub>2</sub> signaling essential to embryo implantation with implication in cancer progression as well. 29108246 2017
Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
0.020 Biomarker phenotype BEFREE ABCG2, CD133 and CD117 are pivotal markers of cancer stem cell, which are involved in carcinogenesis and cancer progression. 26951883 2017
Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
0.020 Biomarker phenotype BEFREE Cytoplasmatic accumulation of ABCG2 in poorly differentiated carcinomas might coincide with malfunctioning of PI3K-signaling pathways during tumor progression. 15146167 2004
Entrez Id: 171022
Gene Symbol: ABHD11-AS1
ABHD11-AS1
0.010 AlteredExpression phenotype BEFREE STAT3-induced upregulation of lncRNA ABHD11-AS1 promotes tumour progression in papillary thyroid carcinoma by regulating miR-1301-3p/STAT3 axis and PI3K/AKT signalling pathway. 30657221 2019
Entrez Id: 10006
Gene Symbol: ABI1
ABI1
0.040 AlteredExpression phenotype BEFREE Down-regulation of E3B1/ABI-1 expression in human carcinomas may play a critical role in tumor progression and in determining disease prognosis. 22430194 2012
Entrez Id: 10006
Gene Symbol: ABI1
ABI1
0.040 Biomarker phenotype BEFREE Because of its role in cell migration, Abi1 has been implicated in tumor progression. 26193797 2015
Entrez Id: 10006
Gene Symbol: ABI1
ABI1
0.040 AlteredExpression phenotype BEFREE The expression of ABI1 and its role in cancer progression and prognosis are largely unknown in the majority of solid tumors, including gastric cancer. 19554484 2010
Entrez Id: 10006
Gene Symbol: ABI1
ABI1
0.040 Biomarker phenotype BEFREE To investigate the molecular mechanism by which loss of ABI1 contributes to tumor progression, we disrupted the ABI1 gene in the benign prostate epithelial RWPE-1 cell line and determined its phenotype. 31530281 2019
Entrez Id: 10152
Gene Symbol: ABI2
ABI2
0.010 AlteredExpression phenotype BEFREE AIP1 Expression in Tumor Niche Suppresses Tumor Progression and Metastasis. 26139244 2015
Entrez Id: 51225
Gene Symbol: ABI3
ABI3
0.010 Biomarker phenotype BEFREE Specifically, in IGHV unmutated CLL, we identified methylation of 7 known or candidate tumor suppressor genes (eg, VHL, ABI3, and IGSF4) as well as 8 unmethylated genes involved in cell proliferation and tumor progression (eg, ADORA3 and PRF1 enhancing the nuclear factor-kappaB and mitogen-activated protein kinase pathways, respectively). 19897574 2010
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.040 Biomarker phenotype BEFREE The interaction between STAP-2 and BCR-ABL plays a crucial role in conferring a growth advantage and resistance to imatinib, a BCR-ABL inhibitor, as well as tumor progression. 22231445 2012
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.040 Biomarker phenotype BEFREE Mutations in the P53 and RAS family genes are associated with tumor progression of BCR/ABL negative chronic myeloproliferative disorders. 8321046 1993
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.040 GeneticVariation phenotype BEFREE CHMFL-ABL-039 has demonstrated greater efficacies than Imatinib regarding to the anti-proliferation, inhibition of the signaling pathway, arrest of cell cycle progression, induction of apoptosis in vitro and suppression of the tumor progression in vivo in the native and V299L mutated BCR-ABL kinase-driven cells/xenograft models. 30894066 2019
Entrez Id: 25
Gene Symbol: ABL1
ABL1
0.040 Biomarker phenotype BEFREE These data indicate that p53 inactivation and/or Ras activation might play a role in acute transformation of BCR/ABL- CMPD and that the molecular mechanisms of tumor progression may be different in BCR/ABL+ versus BCR/ABL-CMPD. 8152300 1994
Entrez Id: 31
Gene Symbol: ACACA
ACACA
0.010 Biomarker phenotype BEFREE Various acetyl-CoA carboxylase 1 (ACC1), and fatty acid synthase (FASN) inhibitors (like Soraphen A and Cerulenin) as well as genetic knockdown approaches were employed to study the effects of disturbed phospholipid composition on membrane properties and its functional impact on cancer progression. 29112683 2018
Entrez Id: 27034
Gene Symbol: ACAD8
ACAD8
0.010 Biomarker phenotype BEFREE We postulate that loss of these tumor suppressor miRNAs predispose to chronic inflammation and neoplastic progression in IBD. 21557394 2012
Entrez Id: 34
Gene Symbol: ACADM
ACADM
0.010 Biomarker phenotype BEFREE Therefore, targeting the caspase-1/PPARγ/MCAD pathway might be a promising therapeutic approach to prevent tumor progression.Tumor associated macrophages (TAMs) promote cancer progression. 28974683 2017
Entrez Id: 176
Gene Symbol: ACAN
ACAN
0.010 Biomarker phenotype BEFREE Overall, the results of the present study show that ADAMTS-5/aggrecanase-2 is the main aggrecanase present in laryngeal carcinoma suggesting a critical role for the enzyme in aggrecan degradation and laryngeal tissue destruction during tumor progression. 23131589 2013