Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 AlteredExpression phenotype BEFREE Moreover, a PTEN inhibitor abolished EHD1 shRNA regulation of EGFR-TKI sensitivity, EMT, and cancer progression. 31740781 2020
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker phenotype BEFREE Alterations in the epidermal growth factor receptor (EGFR) and PI3K pathways in head and neck squamous cell carcinomas (HNSCC) are frequent events that promote tumor progression. 31124563 2020
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 AlteredExpression phenotype BEFREE We found that EGFR is activated in grade II and grade III chondrosarcoma tumors but not in grade I tumors, suggesting a role in tumor progression. 31139331 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker phenotype BEFREE Somatic aberrations of BRCA1 gene are associated with ALDH1, EGFR, and tumor progression in prostate cancer. 30265376 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker phenotype BEFREE The epidermal growth factor receptor (EGFR) and RAS/RAF signaling pathway plays pivotal roles in tumor progression via proliferation, survival, invasion, and immune evasion. 30968289 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker phenotype BEFREE Since EGFR and c-Met are both implicated in oncogenesis and tumor progression, we initiated a screening program by using an in-house library to identify agents capable of inducing the concomitant suppression of EGFR and c-Met expression, which led to the identification of compound 1, a 1,2,4-oxadiazole derivative. 31446247 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker phenotype BEFREE Recent studies in cancer progression have shown that in addition to activating the canonical Smad signaling pathway, TGFβ can also transactivate the epidermal growth factor receptor (EGFR) to enhance invasive cell migration. 30290164 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 GeneticVariation phenotype BEFREE The EGFR resistance mutation T790M should be monitored at cancer progression. 31445213 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker phenotype BEFREE Epidermal growth factor receptor family members such as ErbB1 and ErbB3 are involved in tumor progression and metastasis. 30621788 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker phenotype BEFREE <b>Conclusions:</b> Our findings indicate that IL-22 plays a role in tumor progression and EGFR-TKI resistance in NSCLC. 31750252 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker phenotype BEFREE Epidermal growth factor receptor (EGFR, also known as HER1) and HER2, prominent members of receptor tyrosine kinase (RTK) superfamily, have been reported as diagnostic or prognostic markers in tumor progression. 31493743 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker phenotype BEFREE Our model implies that combining GR modulation to EGFR inhibition may yield an effective treatment strategy in halting cancer progression. 31052457 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker phenotype BEFREE In the case of tumor progression under treatment with third-generation <i>TKIs</i> the <i>EGFR C797S</i> mutation in the <i>cis</i> or <i>trans</i> positions is looked for. 30775029 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker phenotype BEFREE GPAA1 facilitates the expression of cancer-related GPI-anchored proteins and supplies a more robust platform-the lipid raft-to promote EGFR-ERBB2 dimerization, which further contributes to tumour growth and metastasis and to cancer progression. 31118109 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker phenotype BEFREE The epidermal growth factor receptor (EGFR) pathway substrate 8 (Eps8) gene is involved in regulating cancer progression and is considered an attractive target for specific cancer immunotherapy. 31031152 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 AlteredExpression phenotype BEFREE Finally, inhibition of EGFR and c-RAF expression effectively blocked tumor progression in nine independent patient-derived xenografts carrying KRAS and TP53 mutations. 30975481 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker phenotype BEFREE The EGFR/Eps8 complex is involved in regulating cancer progression and might be an ideal target for antitumor therapy. 31118055 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker phenotype BEFREE In conclusion, epidermal LRIG2 excess is associated with activated EGFR/ERBB4-MAPK signaling and accelerated tumor progression in experimentally induced NMSC, suggesting LRIG2 as a potential oncoprotein in skin. 31580518 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker phenotype BEFREE The mechanical modulation of EGFR/ERK during growth-mediated competition for space may contribute to tumor progression. 30554899 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 GeneticVariation phenotype BEFREE KEY POINTS: A rare exon 18 epidermal growth factor receptor mutation with sensitivity to afatinib is reported.Small cell transformation was observed at tumor progression.Acquisition of a SMAD4 mutation was observed at tumor progression. 30413663 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 GeneticVariation phenotype BEFREE A total of 1988 patients receiving first-line gefitinib or erlotinib for the treatment of EGFR-mutated advanced lung adenocarcinoma, with the exclusion of TCM users after tumor progression, were included in this cohort study. 30836771 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 AlteredExpression phenotype BEFREE Epidermal growth factor receptor signalling blockade increases CCL5 expression that regulates either the anti-tumour immune response or tumour progression. 30554073 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker phenotype BEFREE This review mainly focused on modulation of genes like CD44, EGFR, and Rac pathway intermediates which play a crucial role in the tumor progression, metastasis, proliferation, and invasion characteristics in epithelial cancers with EMT properties. 30799784 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 Biomarker phenotype BEFREE EGFR and EGFRvIII cooperate to promote tumor progression and invasion, in part, through activation of the Stat signaling pathway. 29724813 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.100 GeneticVariation phenotype BEFREE Detection of EGFR mutations in circulating cell-free DNA (cfDNA) is beneficial to monitor the therapeutic effect, tumor progression, and drug resistance in real time. 30128808 2018