Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.100 Biomarker phenotype BEFREE Alterations in the epidermal growth factor receptor (EGFR) and PI3K pathways in head and neck squamous cell carcinomas (HNSCC) are frequent events that promote tumor progression. 31124563 2020
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.100 Biomarker phenotype BEFREE Bladder cancer cell‑secreted exosomal miR‑21 activates the PI3K/AKT pathway in macrophages to promote cancer progression. 31814034 2020
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.100 Biomarker phenotype BEFREE The PI3K pathway is a major driver of cancer progression. 31310053 2019
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.100 Biomarker phenotype BEFREE The PI3K/Akt signaling, a well-known carcinogenic signaling pathway in human cancer, cooperates with other signaling pathways such as Wnt signaling to promote cancer progression. 31601147 2019
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.100 Biomarker phenotype BEFREE Phosphoinositide 3-kinases (PI3Ks) are crucial for cell proliferation, metabolism, motility, and cancer progression. 31338599 2019
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.100 Biomarker phenotype BEFREE The PI3K/AKT signaling pathway plays a role in most cellular functions linked to cancer progression, including cell growth, proliferation, cell survival, tissue invasion and angiogenesis. 30875364 2019
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.100 AlteredExpression phenotype BEFREE Testis-specific protein, Y-linked 1 activates PI3K/AKT and RAS signaling pathways through suppressing IGFBP3 expression during tumor progression. 30815935 2019
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.100 Biomarker phenotype BEFREE Enormous efforts have been dedicated to the development of drugs targeting PI3K signaling, many of which are currently employed in clinical trials evaluation, and it is becoming increasingly clear that PI3K inhibitors are effective in inhibiting tumor progression. 30782187 2019
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.100 Biomarker phenotype BEFREE Chemokine (C-X-C motif) ligand 8 (CXCL8) is involved in acute inflammation and tumor progression through the phosphoinositide-3-kinase/protein kinase B/nuclear factor-κB (PI3K/Akt/NF-κB)-signaling pathway. 30362547 2019
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.100 Biomarker phenotype BEFREE PI3K-AKT signaling is recognized to modulate cancer progression. 31059194 2019
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.100 Biomarker phenotype BEFREE Wnt/β-catenin signaling has also linked to other pathways such as NF-κB and PI3K-Akt involving cancer progression. 31721699 2019
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.100 AlteredExpression phenotype BEFREE The pathways regulating PI3K-Akt signaling and Ras signaling were activated in Fvb mice and promoted tumor progression. 29712537 2018
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.100 Biomarker phenotype BEFREE Dysregulation of the phosphatidylinositol 3-kinase (PI3K) pathway is frequent in advanced follicular (FTC) and poorly differentiated thyroid (PDTC) carcinomas and has been implicated in oncogenesis and tumor progression. 30105951 2018
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.100 Biomarker phenotype BEFREE The overexpression of miR-19b serves as a candidate prognostic biomarker of breast cancer and may be involved in the tumor progression through PI3K/AKT pathway. 30038508 2018
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.100 AlteredExpression phenotype BEFREE <b>Purpose:</b> PI3K and STAT3 are frequently activated in cancer progression. 29540490 2018
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.100 Biomarker phenotype BEFREE β4-Integrin/PI3K Signaling Promotes Tumor Progression through the Galectin-3-<i>N</i>-Glycan Complex. 29549127 2018
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.100 Biomarker phenotype BEFREE The overexpression of CD44 in cancer cells reroutes number of oncogenic pathways including the central Pi3K/Akt/NF-kB pathway leading to cancer progression and malignancy. 27989859 2017
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.100 AlteredExpression phenotype BEFREE Hyper-activation of the MAPK and PI3K-AKT pathways is linked to tumour progression in triple-negative breast cancer (TNBC). 28576487 2017
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.100 Biomarker phenotype BEFREE Prompted by our observation of a correlation between PTEN loss and FAK phosphorylation in a cohort of patients with stage IV SCC, we evaluated the relevance of PTEN loss in cancer progression as well as the efficacy of a new combined treatment with the pan PI3K inhibitor buparlisip and the FAK inhibitor defactinib. 28881794 2017
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.100 GeneticVariation phenotype BEFREE Moreover, PI3Kα is implicated in the direct regulation of tumor angiogenesis, and dysregulation of the PI3K pathway in stromal fibroblasts can also contribute to cancer progression. 28273837 2017
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.100 Biomarker phenotype BEFREE PI3Kγ Activates Integrin α<sub>4</sub> and Promotes Immune Suppressive Myeloid Cell Polarization during Tumor Progression. 28963139 2017
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.100 AlteredExpression phenotype BEFREE Our results show that ANGPTL4 is induced by hypoxia and promotes cancer progression via the activated PI3K/Akt pathway. 28560449 2017
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.100 GeneticVariation phenotype BEFREE Here, we show that a single Arginine (R) to Glycine (G) mutation at position 76 in the refp17 backbone (p17R76G), as in the S75X variant, is per se sufficient to confer a B-cell clonogenic potential to the viral protein and modulate, through activation of the PTEN/PI3K/Akt signaling pathway, different molecules involved in apoptosis inhibition (CASP-9, CASP-7, DFF-45, NPM, YWHAZ, Src, PAX2, MAPK8), cell cycle promotion and cancer progression (CDK1, CDK2, CDK8, CHEK1, CHEK2, GSK-3 beta, NPM, PAK1, PP2C-alpha). 28747658 2017
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.100 Biomarker phenotype BEFREE Urokinase plasminogen activator secreted by cancer-associated fibroblasts induces tumor progression via PI3K/AKT and ERK signaling in esophageal squamous cell carcinoma. 28404945 2017
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
0.100 Biomarker phenotype BEFREE Phosphatase and tension homolog (PTEN) acts as a negative regulator of the phosphatidylinositol 3-kinase (PIK3)/Akt pathway and suppresses tumor progression. 29123407 2017